Patents by Inventor Richard P. Dunlap
Richard P. Dunlap has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6946562Abstract: Disclosed is a process for the preparation of a peptoid substituted azole compound comprising reacting an amino functionalized azole compound with a resin bound peptoid oligomer bearing a terminal halogen substituent followed by cleavage of the resultant product from the resin surface using a fluorinated organic acid in an inert solvent.Type: GrantFiled: December 12, 2001Date of Patent: September 20, 2005Assignee: Eastman Kodak CompanyInventors: Donald R. Diehl, Robert J. Niger, Hans F. Schmitthenner, William J. Sonnefeld, Richard P. Dunlap
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Publication number: 20030187188Abstract: Disclosed is a process for the preparation of a peptoid substituted azole compound comprising reacting an amino functionalized azole compound with a resin bound peptoid oligomer bearing a terminal halogen substituent followed by cleavage of the resultant product from the resin surface using a fluorinated organic acid in an inert solvent.Type: ApplicationFiled: December 12, 2001Publication date: October 2, 2003Inventors: Donald R. Diehl, Robert J. Niger, Hans F. Schmitthenner, William J. Sonnefeld, Richard P. Dunlap
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Patent number: 6514679Abstract: Disclosed is a photographic element comprising a silver halide emulsion and a peptoid-containing azole dye-forming coupler.Type: GrantFiled: December 12, 2001Date of Patent: February 4, 2003Assignee: Eastman Kodak CompanyInventors: Donald R. Diehl, Robert J. Niger, Richard P. Dunlap, William J. Sonnefeld, Hans F. Schmitthenner
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Patent number: 5597841Abstract: 4-R.sup.4 -R.sup.5 -2-Saccharinylmethyl aryl carboxylates, useful in the treatment of degenerative diseases, are prepared by reacting a 4-R.sup.4 -R.sup.5 -2-halomethylsaccharin with an arylcarboxylic acid in the presence of an acid-acceptor.Type: GrantFiled: May 19, 1995Date of Patent: January 28, 1997Assignee: Sterling Winthrop, Inc.Inventors: Richard P. Dunlap, Neil W. Boaz, Albert J. Mura, Virendra Kumar, Chakrapani Subramanyam, Ranjit C. Desai, Dennis J. Hlasta, Manohar T. Saindane, Malcolm R. Bell, John J. Court, Robert P. Farrell
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Patent number: 5596012Abstract: Novel 2-substituted saccharins which inhibit the enzymatic activity of proteolytic enzymes, are useful in the treatment of degenerative diseases and have the formula ##STR1## wherein: L is --O--, --S--, --SO--or --SO.sub.2 --;m and n are each independently 0 or 1;R.sub.1 is halo, lower-alkanoyl, 1-oxophenalenyl, phenyl or substituted phenyl, heterocyclyl or substituted heterocyclyl or, when L is --O-- and n is 1, cycloheptatrienon-2-yl or, when L is --S-- and n is 1, cyano or lower-alkoxythiocarbonyl or, when L is --SO.sub.2 -- and n is 1, lower-alkyl or trifluoromethyl; R.sub.2 is hydrogen, lower-alkoxycarbonyl, phenyl or phenylthio; andR.sub.3 and R.sub.4 are each hydrogen or various substituents and processes for preparation and pharmaceutical compositions and method of use thereof are disclosed.Type: GrantFiled: May 24, 1995Date of Patent: January 21, 1997Assignee: Sterling winthrop Inc.Inventors: Richard P. Dunlap, Neil W. Boaz, Albert J. Mura, Dennis J. Hlasta, Ranjit C. Desai, Chakrapani Subramanyam, Lee H. Latimer, Eric P. Lodge
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Patent number: 5578623Abstract: Compounds having the structural formula ##STR1## wherein L is O;L-R.sup.1 is a leaving group, H-L-R.sup.1 is the conjugate acid thereof and H-L-R.sup.1 has a pK.sub.a value less than or equal to to 8;R.sup.2 is primary or secondary alkyl of two to four carbon atoms, primary alkylamino of one to three carbon atoms, primary alkylmethylamino of two to four carbon atoms, diethylamino or primary alkoxy of one to three carbon atoms; andR.sup.3 is from one to three of a variety of substituents at any or all of the 5-, 6- and 7-positions;or a pharmaceutically acceptable acid addition salt thereof if the compound has a basic functional group or a pharmaceutically acceptable acid addition salt thereof if the compound has an acidic functional group,which inhibit the enzymatic activity of proteolytic enzymes, and processes for preparation thereof, method of use thereof in treatment of degenerative diseases and pharmaceutical compositions thereof are disclosed.Type: GrantFiled: May 19, 1995Date of Patent: November 26, 1996Assignee: Sterling Winthrop Inc.Inventors: Richard P. Dunlap, Albert J. Mura, Dennis J. Hlasta, Ranjit C. Desai, Lee H. Latimer, Chakrapani Subramanyam
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Patent number: 5563163Abstract: 4-R.sup.4 -R.sup.5 -2-Saccharinylmethyl heterocyclic carboxylates, useful in the treatment of degenerative diseases, are prepared by reacting a 4-R.sup.4 -R.sup.5 -2-halomethylsaccharin with either a heterocyclic carboxylic acid in the presence of an acid-acceptor or the alkali metal salt of a heterocyclic carboxylic acid.Type: GrantFiled: May 19, 1995Date of Patent: October 8, 1996Assignee: Sterling Winthrop, Inc.Inventors: Richard P. Dunlap, Dennis J. Hlasta, Ranjit C. Desai, Lee H. Latimer, Chakrapani Subramanyam, John J. Court, Malcolm R. Bell, Virendra Kumar
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Patent number: 5512589Abstract: A compound having the formula: ##STR1## wherein Ar, R.sup.4 and R.sup.5 are defined herein have pharmaceutical utility as proteolytic enzyme inhibitors.Type: GrantFiled: September 3, 1993Date of Patent: April 30, 1996Assignee: Sterling Winthrop Inc.Inventors: Richard P. Dunlap, Neil W. Boaz, Albert J. Mura, Virendra Kumar, Chakrapani Subramanyam, Ranjit C. Desai, Dennis J. Hlasta, Manohar T. Saindane, Malcolm R. Bell, John J. Court, Robert P. Farrell
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Patent number: 5489604Abstract: 4-R.sup.4 -R.sup.5 -2-Saccharinylmethyl aryl and aryloxy acetates, useful in the treatment of degenerative diseases, are prepared by reacting a 4-R.sup.4 -R.sup.5 -2-halomethylsaccharin with an aryl or aryloxyacetic acid in the presence of an acid-acceptor.Type: GrantFiled: August 8, 1994Date of Patent: February 6, 1996Assignee: Sterling Winthrop, Inc.Inventors: Lee H. Latimer, Richard P. Dunlap
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Patent number: 5488062Abstract: 4-R.sup.4 -R.sup.5 -2-Saccharinylmethyl heterocyclic carboxylates, useful in the treatment of degenerative diseases, are prepared by reacting a 4-R.sup.4 -R.sup.5 -2-halomethylsaccharin with either a heterocyclic carboxylic acid in the presence of an acid-acceptor or the alkali metal salt of a heterocyclic carboxylic acid.Type: GrantFiled: August 9, 1994Date of Patent: January 30, 1996Assignee: Sterling Winthrop Inc.Inventors: Richard P. Dunlap, Dennis J. Hlasta, Ranjit C. Desai, Lee H. Latimer, Chakrapani Subramanyam, John J. Court, Malcolm R. Bell, Virendra Kumar
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Patent number: 5464852Abstract: Compounds having the structural formula ##STR1## wherein L is N, O or SO.sub.n wherein n is 0, 1 or 2;L--R.sup.1 is a leaving group, H--L--R.sup.1 is the conjugate acid thereof and,when L is N, H--L--R.sup.1 has a pK.sub.a value less than or equal to 6, when L is O, H--L--R.sup.1 has a pK.sub.a value less than or equal to to 8, and when L is SO.sub.n, H--L--R.sup.1 has a pK.sub.a value less than or equal to 5;R.sup.2 is primary or secondary alkyl of two to four carbon atoms, primary alkylamino of one to three carbon atoms, primary alkylmethylamino of two to four carbon atoms, diethylamino or primary alkoxy of one to three carbon atoms; andR.sup.Type: GrantFiled: August 11, 1994Date of Patent: November 7, 1995Assignee: Sterling Winthrop Inc.Inventors: Richard P. Dunlap, Albert J. Mura, Dennis J. Hlasta, Ranjit C. Desai, Lee H. Latimer, Chakrapani Subramanyam
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Patent number: 5385923Abstract: 4-R.sup.4 --R.sup.5 -2-Saccharinylmethyl aryl and aryloxy acetates, useful in the treatment of degenerative diseases, are prepared by reacting a 4-R.sup.4 --R.sup.5 -2-halomethylsaccharin with an aryl or aryloxyacetic acid in the presence of an acid-acceptor.Type: GrantFiled: August 20, 1993Date of Patent: January 31, 1995Assignee: Sterling Winthrop Inc.Inventors: Lee H. Latimer, Richard P. Dunlap
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Patent number: 5380737Abstract: Compounds having the structural formula ##STR1## wherein L is N, O or SO.sub.n wherein n is 0, 1 or 2;L-R.sup.1 is a leaving group, H-L-R.sup.1 is the conjugate acid thereof and, when L is N, H-L-R.sup.1 has a pK.sub.a value less than or equal to 6, when L is O, H-L-R.sup.1 has a pK.sub.a value less than or equal to to 8, and when L is SO.sub.n, H-L-R.sup.1 has a pK.sub.a value less than or equal to 5;R.sup.2 is primary or secondary alkyl of two to four carbon atoms, primary alkylamino of one to three carbon atoms, primary alkylmethylamino of two to four carbon atoms, diethylamino or primary alkoxy of one to three carbon atoms; andR.sup.Type: GrantFiled: August 27, 1993Date of Patent: January 10, 1995Assignee: Sterling Winthrop Inc.Inventors: Richard P. Dunlap, Albert A. Mura, Dennis J. Hlasta, Ranjit C. Desai, Lee H. Latimer, Chakrapani Subramanyam
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Patent number: 5376653Abstract: 4-R.sup.4 -R.sup.5 -2-Saccharinylmethyl heterocyclic carboxylates, useful in the treatment of degenerative diseases, are prepared by reacting a 4-R.sup.4 -R.sup.5 -2-halomethylsaccharin with either a heterocyclic carboxylic acid in the presence of an acid-acceptor or the alkali metal salt of a heterocyclic carboxylic acid.Type: GrantFiled: August 19, 1993Date of Patent: December 27, 1994Assignee: Sterling Winthrop Inc.Inventors: Richard P. Dunlap, Lee H. Latimer, Chakrapani Subramanyam
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Patent number: 5371074Abstract: Novel 2-substituted saccharins which inhibit the enzymatic activity of proteolytic enzymes, are useful in the treatment of degenerative diseases and have the formula 0010wherein:L is --O--, --S--, --SO-- or --SO.sub.2 --; m and n are each independently 0 or 1; R.sub.1 is halo, lower-alkanoyl, 1-oxophenalenyl, phenyl or substituted phenyl, heterocyclyl or substitued heterocyclyl or, when L is --O-- and n is 1, cycloheptatrienon-2-yl or, when L is --S-- and n is 1, cyano or lower-alkoxythiocarbonyl or, when L is --SO.sub.2 -- and n is 1, lower-alkyl or trifluoromethyl; R.sub.2 is hydrogen, lower-alkoxycarbonyl, phenyl or phenylthio; and R.sub.3 and R.sub.4 are each hydrogen or various substituents and processes for preparation and pharmaceutical compositions and method of use thereof are disclosed.Type: GrantFiled: May 24, 1993Date of Patent: December 6, 1994Assignee: Sterling Winthrop Inc.Inventors: Richard P. Dunlap, Neil W. Boaz, Albert J. Mura, Dennis J. Hlasta, Ranjit C. Desai, Chakrapani Subramanyam, Lee H. Latimer, Eric P. Lodge
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Patent number: 5250696Abstract: 4-R.sup.4 -R.sup.5 -2-Saccharinylmethyl aryl carboxylates, useful in the treatment of degenerative diseases, are prepared by reacting a 4-R.sup.4 -R.sup.5 -2-halomethylsaccharin with an arylcarboxylic acid in the presence of an acid-acceptor.Type: GrantFiled: March 30, 1992Date of Patent: October 5, 1993Assignee: Sterling Winthrop Inc.Inventors: Richard P. Dunlap, Neil W. Boaz, Albert J. Mura, Virendra Kumar, Chakrapani Subramanyam, Ranjit C. Desai, Dennis J. Hlasta, Manohar T. Saindane, Malcolm R. Bell, John J. Court
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Patent number: 5236917Abstract: Novel 2-substituted saccharins which inhibit the enzymatic activity of proteolytic enzymes, are useful in the treatment of degenerative diseases and have the formula ##STR1## wherein: L is --O--, --S--, --SO-- or --SO.sub.2 --;m and n are each independently 0 or 1;R.sub.1 is halo, lower-alkanoyl, 1-oxophenalenyl, phenyl or substituted phenyl, heterocyclyl or substituted heterocyclyl or, when L is --O-- and n is 1, cycloheptatrienon-2-yl or, when L is --S-- and n is 1, cyano or lower-alkoxythiocarbonyl or, when L is --SO.sub.2 -- and n is 1, lower-alkyl or trifluoromethyl;R.sub.2 is hydrogen, lower-alkoxycarbonyl, phenyl or phenylthio; andR.sub.3 and R.sub.4 are each hydrogen or various substituents and processes for preparation and pharmaceutical compositions and method of use thereof are disclosed.Type: GrantFiled: November 15, 1991Date of Patent: August 17, 1993Assignee: Sterling Winthrop Inc.Inventors: Richard P. Dunlap, Neil W. Boaz, Albert J. Mura, Dennis J. Hlasta, Ranjit C. Desai, Chakrapani Subramanyam, Lee H. Latimer, Eric P. Lodge
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Patent number: 5128339Abstract: 4-R.sup.4 -R.sup.5 -2-Saccharinylmethyl aryl carboxylates, useful in the treatment of degenerative diseases, are prepared by reacting a 4-R.sup.4 -R.sup.5 -2-halomethylsaccharin with an arylcarboxylic acid in the presence of an acid-acceptor.Type: GrantFiled: October 24, 1991Date of Patent: July 7, 1992Assignee: Sterling Winthrop Inc.Inventors: Richard P. Dunlap, Neil W. Boaz, Albert J. Mura, Virendra Kumar, Chakrapani Subramanyam, Ranjit C. Desai, Dennis J. Hlasta, Manohar T. Saindane, Malcolm R. Bell, John J. Court
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Patent number: 4609610Abstract: Photographic elements and assemblages are described which employ nondiffusible compounds which release photographically useful groups in an imagewise manner as the result of a .beta.-elimination reaction.Type: GrantFiled: August 1, 1985Date of Patent: September 2, 1986Assignee: Eastman Kodak CompanyInventors: Richard P. Dunlap, Thomas E. Gompf
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Patent number: 4139379Abstract: Photographic elements, processes for forming images in photographic elements and new compounds are disclosed. Generally, the invention relates to ballasted electron-accepting nucleophilic displacement compounds; after acceptance of at least one electron (reduction) by a nucleophile precursor group, the compounds are capable of undergoing intramolecular nucleophilic displacement to release a diffusible moiety, such as an image dye or a photographic reagent. In certain embodiments, the ballasted electron-accepting nucleophilic displacement compounds are used in combination with electron donors and electron-transfer agents. The processes disclosed are particularly useful in providing positive transfer images using negative-working silver halide emulsions.Type: GrantFiled: March 7, 1977Date of Patent: February 13, 1979Assignee: Eastman Kodak CompanyInventors: Richard A. Chasman, Richard P. Dunlap, Jerald C. Hinshaw