Patents by Inventor Richard P. Gill

Richard P. Gill has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20140155282
    Abstract: Methods of determining stabilization compounds for predictive biomarkers. According to at least one embodiment of a method of the present disclosure, the method comprises introducing a diagnostic marker and a stabilization agent to a detection platform, mixing the diagnostic marker and stabilization agent, and determining their binding characteristics. Additionally, the method may further comprise generating a report based on the binding characteristics and delivering the report to a recipient.
    Type: Application
    Filed: June 6, 2013
    Publication date: June 5, 2014
    Applicant: Companion Diagnostics, Inc.
    Inventors: Richard H. Selinfreund, Rakesh Vig, Richard P. Gill
  • Patent number: 8574856
    Abstract: Methods for determining the efficiency of a therapeutic. In at least one embodiment of a method of determining the efficacy of a therapeutic compound, the method comprises the steps of treating a subject having a disease state with an effective amount of therapeutic compound, harvesting at least one cell from the subject following a treatment with the therapeutic compound, bringing the at least one cell into contact with a stabilizing compound capable of completely or substantially preventing the degradation or inactivation of a diagnostic marker for the disease state, analyzing the at least one stabilized cell for the at least one diagnostic marker, creating a marker profile from at least one result determined from analyzing the at least one stabilized cell, and comparing the marker profile with at least one previous marker profile to determine efficacy of the therapeutic compound on the disease state.
    Type: Grant
    Filed: October 18, 2010
    Date of Patent: November 5, 2013
    Assignee: Companion Diagnostics Inc.
    Inventors: Richard H. Selinfreund, Rakesh Vig, Richard P. Gill
  • Patent number: 8501669
    Abstract: Systems and methods of screening biomarkers in bodily fluids. According to at least one embodiment of the system for analyzing stabilizing agents of the present disclosure, the system comprises a detection platform comprising a plurality of detection sites each capable of receiving a diagnostic marker, a stabilization agent, and a detection agent. The system, in at least one embodiment, further comprises a detection device capable of determining a binding characteristic between the detection agent and the diagnostic marker in the detection sites. Further, the system may also be able to compare the binding characteristic among a plurality of detection markers to order the level of effect of the stabilizing agents assayed on the binding characteristic between the detection agent and the diagnostic agent.
    Type: Grant
    Filed: October 18, 2010
    Date of Patent: August 6, 2013
    Assignee: Companion Diagnostics Inc.
    Inventors: Richard H. Selinfreund, Rakesh Vig, Richard P. Gill
  • Patent number: 8426151
    Abstract: System and methods for the detection of biomarkers. In at least one embodiment of a system for the detection of a diagnostic marker in a body fluid of the present disclosure, the system comprises a diagnostic device comprising a plurality of test wells, wherein each test well is capable of containing at least one detection agent, a detection device capable of interacting with the diagnostic device, wherein the detection device is capable of detecting an interaction between the at least one detection agent and a diagnostic marker in at least one of the plurality of test wells, and a stabilization agent contained within at least one of the plurality of test wells, the stabilization agent capable of completely or substantially preventing the degradation or inactivation of the detection agent or the diagnostic marker.
    Type: Grant
    Filed: October 18, 2010
    Date of Patent: April 23, 2013
    Assignee: Companion Diagnostics Inc.
    Inventors: Richard H. Selinfreund, Rakesh Vig, Richard P. Gill
  • Patent number: 8318641
    Abstract: Systems and methods for the detection of biomarkers. In at least one embodiment of a microarray system of the present disclosure, the microarray system comprises a microarray product comprising at least 100 diagnostic markers/cm2, a microarray identifier, and a stabilizing agent, a control microarray product comprising a first specific binding pair member that binds to a first detectable label, and a processor for providing information regarding the identification and concentration of markers on the microarray based on the identity of the array provided by the microarray identifier.
    Type: Grant
    Filed: October 18, 2010
    Date of Patent: November 27, 2012
    Inventors: Richard H. Selinfreund, Rakesh Vig, Richard P. Gill
  • Patent number: 8318105
    Abstract: Systems and methods of biomarker analysis. In at least one embodiment of a system for determining the therapeutic potential of a therapeutic compound the present disclosure, the system comprises a detection platform, a computer database capable of receiving a plurality of binding characteristics, a processor operably coupled to the computer database and the detection platform. In at least one embodiment, the processor has and executes a software program operational to determine a binding characteristic of the detection agent and a stabilized diagnostic agent in each of the plurality of detection sites, compare the binding characteristic among each of the plurality of detection sites, wherein the comparison of binding characteristics is capable of determining the stabilizing agent with the greatest effect on the binding characteristic between the detection agent and the diagnostic agent, generate a binding record using the compared binding characteristics, and deliver the binding record to a recipient.
    Type: Grant
    Filed: October 18, 2010
    Date of Patent: November 27, 2012
    Inventors: Richard H. Selinfreund, Rakesh Vig, Richard P. Gill
  • Patent number: 8293537
    Abstract: At least one embodiment of a stabilizing system includes a stabilizing agent present in an amount or concentration sufficient to completely or substantially prevent or reduce degradation or inactivation of a glycosylated hemoglobin (HbA1c) in a body fluid and a detection agent capable of detecting the HbA1c.
    Type: Grant
    Filed: October 18, 2010
    Date of Patent: October 23, 2012
    Inventors: Richard H. Selinfreund, Rakesh Vig, Richard P. Gill
  • Publication number: 20120164674
    Abstract: Herein are disclosed compositions, washes, rinses, devices, systems and methods for biomarker stabilization, in part in bodily fluids, as well as methods and formulations for improving the sampling and testing of fluids for biomarkers.
    Type: Application
    Filed: October 27, 2011
    Publication date: June 28, 2012
    Inventors: Richard H. Selinfreund, Rakesh Vig, Richard P. Gill
  • Publication number: 20110196085
    Abstract: Biomarker stabilizing agents. In at least one embodiment of a stabilizing bead of the present disclosure, the stabilizing bead comprises a latex particle having a carboxylate group, and a stabilizing agent functionally coupled to the latex particle, wherein the stabilizing agent is capable of completely or substantially preventing the degradation or inactivation of a diagnostic agent in close proximity to the stabilizing agent. Optionally, an embodiment of a stabilizing bead may further comprise at least one of human serum albumin (HSA) and bovine serum albumin (BSA). Moreover, an embodiment of a stabilizing bead of the present disclosure may further comprise a linker group coupled to latex particle.
    Type: Application
    Filed: October 18, 2010
    Publication date: August 11, 2011
    Inventors: Richard H. Selinfreund, Rakesh Vig, Richard P. Gill
  • Publication number: 20110195857
    Abstract: Systems for analyzing stabilized biomarkers. In at least one embodiment of a system for the detection of a diagnostic marker of the present disclosure, the system comprises a detection platform comprising a plurality of detection wells housed in a solid matrix, wherein the detection wells contain a plurality of diagnostic markers and at least one competitor molecule, wherein the plurality of diagnostic markers and at least one control molecule are each bound to a paramagnetic particle. An embodiment of the system of the present disclosure further comprises a detection system capable of receiving the detection platform, exerting a magnetic field upon a surface of the detection platform, and determining at least one characteristic of the diagnostic marker.
    Type: Application
    Filed: October 18, 2010
    Publication date: August 11, 2011
    Inventors: Richard H. Selinfreund, Rakesh Vig, Richard P. Gill
  • Publication number: 20110195398
    Abstract: Systems and methods for detecting insulin resistance biomarkers. At least one embodiment of a system of the present disclosure comprises a stabilizing agent useful to completely or substantially prevent degradation or inactivation of a diagnostic marker for insulin resistance or glucose intolerance in a body fluid comprising the diagnostic marker, and a detection agent capable of detecting the diagnostic marker.
    Type: Application
    Filed: October 18, 2010
    Publication date: August 11, 2011
    Inventors: Richard H. Selinfreund, Rakesh Vig, Richard P. Gill
  • Publication number: 20110195427
    Abstract: Systems and methods for detecting pregnancy. In at least one embodiment of a system of the present disclosure, the system comprises a stabilizing agent useful to completely or substantially prevent degradation or inactivation of a diagnostic marker for pregnancy in a body fluid comprising the diagnostic marker, and a detection agent capable of detecting the diagnostic agent.
    Type: Application
    Filed: October 18, 2010
    Publication date: August 11, 2011
    Inventors: RICHARD H. SELINFREUND, Rakesh Vig, Richard P. Gill
  • Publication number: 20110195424
    Abstract: Systems and methods for diagnosing fungal infections. According to at least one embodiment of a stabilizing system of the present disclosure, the system comprises a stabilizing agent useful to completely or substantially prevent degradation or inactivation of a diagnostic marker for a fungal infection in a body fluid comprising the diagnostic marker and a detection agent capable of detecting the diagnostic marker.
    Type: Application
    Filed: October 18, 2010
    Publication date: August 11, 2011
    Inventors: Richard H. Selinfreund, Rakesh Vig, Richard P. Gill
  • Publication number: 20110195856
    Abstract: Methods of determining stabilization compounds for predictive biomarkers. According to at least one embodiment of a method of the present disclosure, the method comprises introducing a diagnostic marker and a stabilization agent to a detection platform, mixing the diagnostic marker and stabilization agent, and determining their binding characteristics. Additionally, the method may further comprise generating a report based on the binding characteristics and delivering the report to a recipient.
    Type: Application
    Filed: October 18, 2010
    Publication date: August 11, 2011
    Inventors: Richard H. Selinfreund, Rakesh Vig, Richard P. Gill
  • Publication number: 20110195403
    Abstract: Systems and methods for fertility analysis. In at least one embodiment of a system of the present disclosure, the system comprises a stabilizing agent useful to completely or substantially prevent degradation or inactivation of a diagnostic marker for fertility in a body fluid comprising the diagnostic marker, and a detection agent capable of detecting the diagnostic agent. In an exemplary embodiment, the stabilizing agent may be selected from the group consisting of a protease inhibitor, a DNase inhibitor, and a RNase inhibitor.
    Type: Application
    Filed: October 18, 2010
    Publication date: August 11, 2011
    Inventors: RICHARD H. SELINFREUND, Rakesh Vig, Richard P. Gill
  • Publication number: 20110195488
    Abstract: Device for collection and stabilization of biomarkers in liquid samples. In at least one embodiment of a fluid collection device, the device comprises a first tube operable to receive a body fluid, a second tube operable to dispense a body fluid, and a suction device operably connected to the second opening of the first tube and the first end of the second tube, wherein the suction device is operable to produce negative pressure through the first tube and is operable to exert positive pressure through the second tube. An embodiment of the devices also comprises a stabilizing agent contained within the fluid collection device, the stabilizing agent capable of completely or substantially preventing the degradation or inactivation of a diagnostic agent in a body fluid upon receipt of the body fluid into the fluid collection device.
    Type: Application
    Filed: October 18, 2010
    Publication date: August 11, 2011
    Inventors: Richard H. Selinfreund, Rakesh Vig, Richard P. Gill
  • Publication number: 20110195440
    Abstract: Systems and methods for identifying allergies. In at least one embodiment of a system of the present disclosure, the system comprises a stabilizing agent useful to completely or substantially prevent degradation or inactivation of a diagnostic marker for a non-food allergy in a body fluid comprising the diagnostic marker and a detection agent capable of detecting the diagnostic marker.
    Type: Application
    Filed: October 18, 2010
    Publication date: August 11, 2011
    Inventors: RICHARD H. SELINFREUND, Rakesh Vig, Richard P. Gill
  • Publication number: 20110195423
    Abstract: Systems and methods for diagnosing bacterial infections. According to at least one embodiment of a system of the present disclosure, the system a stabilizing agent useful to completely or substantially prevent degradation or inactivation of a diagnostic marker for a bacterial infection in a body fluid comprising the diagnostic marker and a detection agent capable of detecting the diagnostic marker.
    Type: Application
    Filed: October 18, 2010
    Publication date: August 11, 2011
    Inventors: Richard H. Selinfreund, Rakesh Vig, Richard P. Gill
  • Publication number: 20110195873
    Abstract: Systems and methods for the detection of biomarkers. In at least one embodiment of a microarray system of the present disclosure, the microarray system comprises a microarray product comprising at least 100 diagnostic markers/cm2, a microarray identifier, and a stabilizing agent, a control microarray product comprising a first specific binding pair member that binds to a first detectable label, and a processor for providing information regarding the identification and concentration of markers on the microarray based on the identity of the array provided by the microarray identifier.
    Type: Application
    Filed: October 18, 2010
    Publication date: August 11, 2011
    Inventors: Richard H, Selinfreund, Rakesh Vig, Richard P. Gill
  • Publication number: 20110195858
    Abstract: Systems and methods of analyzing biomarker levels. In at least one embodiment of a method of analyzing biomarker levels, the method comprises the steps of combining a body fluid comprising a diagnostic marker with a stabilization agent for an incubation period, introducing the stabilized body fluid into a detection platform, combining a detection agent with the stabilized body fluid, determining an interaction characteristic of the detection agent and the diagnostic marker of the stabilized body fluid using a detection device in communication with a processor, comparing the interaction characteristic with a plurality of indexed interaction records contained on a database in communication with the processor to determine an identity and concentration of the detection marker, generating a report of the identity and concentration of the detection marker in the body fluid, and delivering the report to a recipient.
    Type: Application
    Filed: October 18, 2010
    Publication date: August 11, 2011
    Inventors: Richard H. Selinfreund, Rakesh Vig, Richard P. Gill