Abstract: A disposable cover for use with a remote control device for providing a protective sanitation barrier to human infection includes a rear member having a flat surface. A front curved member is integrally molded in a seamless unitary, one-piece construction with the rear member at a plurality of rounded surfaces to form a single-use, disposable protective enclosure. An anti-bacterial compound impregnates the rear member, the front curved member and the rounded surfaces for destroying bacteria on the remote control device. An orifice is formed in the rear member for enabling the remote control device to be inserted into and removed from the enclosure. Finally, the front member, rear member and the rounded surfaces are comprised of a flexible, stretchable and transparent material for conforming to the shape of the remote control device for providing a disposable, protective sanitation barrier to human infection.

Abstract: A method is disclosed for preparing novel PNA synthons having protecting groups capable of removal under mild conditions. The PNA synthons are prepared by coupling novel N-substituted nucleobase intermediates having carbamate protection of the exocyclic amino group of the heterocycle to an amino protected backbone or an amino protected backbone ester of the amino acid N-(2-aminoethyl)-glycine. By the method of this invention, the resultant PNA synthons can have orthogonal protection of the carbamate protected nucleobase and the amino protected backbone. The PNA synthons are useful in the synthesis of peptide nucleic acids (PNAs) and other oligomers such as PNA-DNA chimeras, and may be used in automated synthesizers. Novel compositions of matter are also disclosed. In addition, a guanine PNA synthon having selective carbamate protection of the exocyclic 2-amino group with the C6 carbonyl group unprotected is disclosed.

Abstract: A method is disclosed for preparing novel purine PNA synthons having protecting groups which may be removed under mild conditions. The purine PNA synthons generally are prepared by coupling purine derivatives having carbamate protection to a protected N-(2-aminoethyl)-glycine backbone. By a method of this invention, purine PNA synthons may have orthogonal protection of the carbamate protected purine and the protected backbone. The purine PNA synthons are useful in the synthesis of peptide nucleic acids (PNAs) and other oligomers such as PNA-DNA chimeras, and may be used in automated synthesizers. In practicing methods of the invention, novel compositions of matter also are disclosed.

Abstract: Method for production of 2'-O-derivatized uridine and cytosine RNA synthons comprising derivatizing the 2'-hydroxyl group of a partially protected cytosine ribonucleoside to preferentially produce a partially protected 2'-O-derivatized nucleoside, which is then either (1) reacted at the 3'-hydroxyl group to produce a 2'-O-derivatized cytosine RNA synthon, or (2) reacted with a hydroxide source to produce a uridine nucleobase by deamination, thereby producing a partially protected 2'-O-derivatized uridine ribonucleoside which can be reacted at its 3'-hydroxyl group to produce a uridine RNA synthon.

Abstract: A housing for a computer mouse device which supports the mouse above a working surface on a cushion of air or other gaseous fluid including a support device having incorporated therein structure for the distribution of the fluid between the mouse and the working surface so as to enable support of the mouse device above the working surface.