Patents by Inventor Richard P. Polniaszek

Richard P. Polniaszek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for the preparation of biphenyl isoxazole sulfonamides
    Patent number: 6313308
    Abstract: Methods for the preparation of biphenyl isoxazole sulfonamides and intermediates therof. The present invention also relates to the novel intermediates prepared by these methods. The biphenyl isoxazole sulfonamides prepared by the present methods are endothelin antagonists useful, inter alia, for the treatment of hypertension, congestive heart failure and male erectile dysfunction.
    Type: Grant
    Filed: March 20, 2000
    Date of Patent: November 6, 2001
    Assignee: Bristol-Myers Squibb Company
    Inventors: Ambarish Singh, Chien-Kuang Chen, John A. Grosso, Edward J. Delaney, Xuebao Wang, Richard P. Polniaszek, John K. Thottathil
  • Methods for the preparation of biphenyl isoxazole sulfonamides
    Patent number: 5856507
    Abstract: Methods for the preparation of biphenyl isoxazole sulfonamides and intermediates thereof. The present invention also relates to the novel intermediates prepared by these methods. The biphenyl isoxazole sulfonamides prepared by the present methods are endothelin antagonists useful, inter alia, for the treatment of hypertension.
    Type: Grant
    Filed: January 21, 1997
    Date of Patent: January 5, 1999
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Richard P. Polniaszek, Xuebao Wang, Jeffrey S. DePue, Chennagiri R. Pandit, Kumar G. Gadamasetti, Yadagiri Pendri, Eduardo J. Martinez
  • Process for preparing N-protected amino acid .alpha.-halomethyl ketones and alcohols from N-protected amino acid esters
    Patent number: 5481011
    Abstract: The present invention relates to a novel method useful for the conversion of amino acids to halomethylketones, which are then converted to amino acid epoxides. Such epoxides are important intermediates for the synthesis of inhibitors of renin and HIV protease, which are particularly useful in the treatment and/or prevention of HIV infection (AIDS).
    Type: Grant
    Filed: December 13, 1994
    Date of Patent: January 2, 1996
    Assignee: Bristol-Myers Squibb Company
    Inventors: Ping Chen, Peter T. W. Cheng, Steven H. Spergel, Joel C. Barrish, John K. Thottathil, Robert Zahler, Richard P. Polniaszek, Xuebao Wang