Patents by Inventor Richard P. Van Duyne
Richard P. Van Duyne has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10717647Abstract: A sensing platform includes a substrate, an array of wells formed in the substrate, and sorted nanoparticles filling in the array of wells such that each well contains a single sorted nanoparticle, wherein the sorted nanoparticles are in a cluster state.Type: GrantFiled: September 26, 2017Date of Patent: July 21, 2020Assignee: NORTHWESTERN UNIVERSITYInventors: Timothy P. Tyler, Anne-Isabelle Henry, Richard P. Van Duyne, Mark C. Hersam
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Patent number: 10271780Abstract: The present invention provides systems and methods employing a surface enhanced Raman biosensor and sensing devices for collecting spatially offset Raman spectra from the biosensor. In certain embodiments, the present invention provides systems and methods for quantifying the concentration of an analyte in a subject, and/or identifying the presence or absence of an analyte in a subject, from a plurality of spatially offset Raman spectra generated from a surface enhanced Raman biosensor implanted in a subject.Type: GrantFiled: November 23, 2011Date of Patent: April 30, 2019Assignee: Northwestern UniversityInventors: Richard P. Van Duyne, Matthew R. Glucksberg, Joseph T. Walsh, Jr., Jonathan M. Yuen, Nilam C. Shah
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Publication number: 20180050905Abstract: A sensing platform includes a substrate, an array of wells formed in the substrate, and sorted nanoparticles filling in the array of wells such that each well contains a single sorted nanoparticle, wherein the sorted nanoparticles are in a cluster state.Type: ApplicationFiled: September 26, 2017Publication date: February 22, 2018Inventors: Timothy P. Tyler, Anne-Isabelle Henry, Richard P. Van Duyne, Mark C. Hersam
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Publication number: 20180038799Abstract: The present disclosure provides systems, methods, and kits for identifying and determining the concentration of a drug of interest suspected of being present in an intravenous drug solution. An electrochemical surface enhanced Raman (EC-SERS) substrate is used to acquire an EC-SERS spectrum of the intravenous drug solution. The EC-SERS spectrum is used to identify whether the drug of interest is present in the intravenous drug solution and, if it is present, what the concentration of the drug of interest is in the intravenous drug solution. This identification and concentration determination can be used at the point of delivery to authenticate intravenous drugs.Type: ApplicationFiled: August 3, 2017Publication date: February 8, 2018Inventors: Richard P. Van Duyne, Stephanie Zaleski
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Patent number: 9802818Abstract: In one aspect of the present invention, a method for sorting nanoparticles includes preparing a high-viscosity density gradient medium filled in a container, dispersing nanoparticles into an aqueous solution to form a suspension of the nanoparticles, each nanoparticle having one or more cores and a shell encapsulating the one or more cores, layering the suspension of the nanoparticles on the top of the high-viscosity density gradient medium in the container, and centrifugating the layered suspension of the nanoparticles on the top of the high-viscosity density gradient medium in the container at a predetermined speed for a predetermined period of time to form a gradient of fractions of the nanoparticles along the container, where each fraction comprises nanoparticles in a respective one of aggregation states of the nanoparticles.Type: GrantFiled: May 1, 2012Date of Patent: October 31, 2017Assignee: NORTHWESTERN UNIVERSITYInventors: Timothy P. Tyler, Anne-Isabelle Henry, Richard P. Van Duyne, Mark C. Hersam
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Publication number: 20150051459Abstract: The present invention provides systems and methods employing a surface enhanced Raman biosensor and sensing devices for collecting spatially offset Raman spectra from the biosensor. In certain embodiments, the present invention provides systems and methods for quantifying the concentration of an analyte in a subject, and/or identifying the presence or absence of an analyte in a subject, from a plurality of spatially offset Raman spectra generated from a surface enhanced Raman biosensor implanted in a subject.Type: ApplicationFiled: November 23, 2011Publication date: February 19, 2015Inventors: Richard P. Van Duyne, Matthew R. Glucksberg, Joseph T. Walsh, JR., Jonathan M. Yuen, Nilam C. Shah
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Patent number: 8628727Abstract: The present invention relates to compositions, devices and methods for detecting microorganisms (e.g., anthrax). In particular, the present invention provides portable, surface-enhanced Raman biosensors, and associated substrates, and methods of using the same, for use in rapidly detecting and identifying microorganisms (e.g., anthrax).Type: GrantFiled: August 28, 2007Date of Patent: January 14, 2014Assignee: Northwestern UniversityInventors: Richard P. Van Duyne, Xiaoyu Zhang, Jing Zhao, Alyson V. Whitney, Jeffrey W. Elam, George C. Schatz, Peter C. Stair, Shengli Zou, Matthew Young, Olga Lyandres
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Publication number: 20130330815Abstract: The present invention relates to compositions, devices and methods for detecting microorganisms (e.g., anthrax). In particular, the present invention provides portable, surface-enhanced Raman biosensors, and associated substrates, and methods of using the same, for use in rapidly detecting and identifying microorganisms (e.g., anthrax).Type: ApplicationFiled: August 28, 2007Publication date: December 12, 2013Applicant: Northwestern UniversityInventors: Richard P. Van Duyne, Xiaoyu Zhang, Jing Zhao, Alyson V. Whitney, Jeffrey W. Elam, George C. Schatz, Peter C. Stair, Shengli Zou, Matthew Young, Olga Lyandres
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Patent number: 8592226Abstract: The present invention relates to biosensors, in particular to surface-enhanced Raman biosensors for detection of in vivo and ex vivo analytes. In particular, the present invention provides compositions and methods for the in vivo detection of analytes such as glucose.Type: GrantFiled: September 9, 2009Date of Patent: November 26, 2013Assignee: Northwestern UniversityInventors: Richard P. Van Duyne, Mathew R. Glucksberg, Karen E. Peltier, Christy L. Haynes, Joseph T. Walsh, Chanda Ranjit Yonzon, Nilam C. Shah, Olga Lyandres, Douglas A. Stuart, Jonathan M. Yuen
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Publication number: 20120281213Abstract: In one aspect of the present invention, a method for sorting nanoparticles includes preparing a high-viscosity density gradient medium filled in a container, dispersing nanoparticles into an aqueous solution to form a suspension of the nanoparticles, each nanoparticle having one or more cores and a shell encapsulating the one or more cores, layering the suspension of the nanoparticles on the top of the high-viscosity density gradient medium in the container, and centrifugating the layered suspension of the nanoparticles on the top of the high-viscosity density gradient medium in the container at a predetermined speed for a predetermined period of time to form a gradient of fractions of the nanoparticles along the container, where each fraction comprises nanoparticles in a respective one of aggregation states of the nanoparticles.Type: ApplicationFiled: May 1, 2012Publication date: November 8, 2012Applicant: NORTHWESTERN UNIVERSITYInventors: TIMOTHY P. TYLER, ANNE-ISABELLE HENRY, RICHARD P. VAN DUYNE, MARK C. HERSAM
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Publication number: 20100087723Abstract: The present invention relates to biosensors, in particular to surface-enhanced Raman biosensors for detection of in vivo and ex vivo analytes. In particular, the present invention provides compositions and methods for the in vivo detection of analytes such as glucose.Type: ApplicationFiled: September 9, 2009Publication date: April 8, 2010Inventors: Richard P. Van Duyne, Mathew R. Glucksberg, Karen E. Peltier, Christy L. Haynes, Joseph T. Walsh, Chanda Ranjit Yonzon, Nilam C. Shah, Olga Lyandres, Douglas A. Stuart, Jonathan M. Yuen
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Publication number: 20090118605Abstract: The present invention relates to biosensors, in particular to surface-enhanced Raman biosensors for detection of in vivo and ex vivo analytes. In particular, the present invention provides compositions and methods for the in vivo detection of analytes such as glucose.Type: ApplicationFiled: March 1, 2006Publication date: May 7, 2009Applicant: Northwestern UniversityInventors: Richard P. Van Duyne, Matthew R. Glucksberg, Karen E. Pettier, Christy L. Haynes, Joseph T. Walsh, Chanda Ranjit Yonzon, Nilam C. Shah, Olga Lyandres, Douglas A. Stuart, Jonathan M. Yuen
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Publication number: 20040180379Abstract: The present invention relates to biosensors, in particular to surface-enhanced Raman biosensors for detection of intracellular analytes. In particular, the present invention provides compositions and methods for the in vivo detection of analytes such as glucose.Type: ApplicationFiled: August 29, 2003Publication date: September 16, 2004Applicant: Northwestern UniversityInventors: Richard P. Van Duyne, Matthew R. Glucksberg, Karen Shafer-Peltier, Christy L. Haynes, Joseph Walsh
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Patent number: 5378508Abstract: A method for providing a conductive metal deposit on the surface of a dielectric substrate by applying a composition comprising a mixture of a salt and amine or amide compound to the substrate and subjecting the composition to a continuous wavelength laser beam.Type: GrantFiled: April 1, 1992Date of Patent: January 3, 1995Assignees: Akzo Nobel N.V., Northwestern UniversityInventors: Anthony J. Castro, Richard P. Van Duyne, King C. Sheng, Robert J. Bianchini, William J. Parr, Ralph Franklin, Michael J. Natan