Patents by Inventor Richard Pascal

Richard Pascal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11773362
    Abstract: Bioreactors and components of bioreactors are described as may be beneficially utilized in development and conditioning of cellular materials for study or implant. The bioreactors are modular, and components of the bioreactors can be easily assembled with alternatives provided to develop specific, predetermined conditioning environments for cellular materials (e.g., implantable tissue). By selection of one of multiple alternative compliance chambers, a bioreactor can be utilized to condition tissue in a low-pressure circuit (e.g., a pulmonary heart circuit), and by utilization of an alternative compliance chamber, the bioreactor can instead condition tissue in a high-pressure circuit (e.g., an aortic heart circuit).
    Type: Grant
    Filed: April 29, 2021
    Date of Patent: October 3, 2023
    Assignee: Clemson University Research Foundation
    Inventors: Leslie Sierad, Christopher Delaney, Richard Pascal, III, Dan Simionescu, Agneta Simionescu
  • Publication number: 20210246411
    Abstract: Bioreactors and components of bioreactors are described as may be beneficially utilized in development and conditioning of cellular materials for study or implant. The bioreactors are modular, and components of the bioreactors can be easily assembled with alternatives provided to develop specific, predetermined conditioning environments for cellular materials (e.g., implantable tissue). By selection of one of multiple alternative compliance chambers, a bioreactor can be utilized to condition tissue in a low-pressure circuit (e.g., a pulmonary heart circuit), and by utilization of an alternative compliance chamber, the bioreactor can instead condition tissue in a high-pressure circuit (e.g., an aortic heart circuit).
    Type: Application
    Filed: April 29, 2021
    Publication date: August 12, 2021
    Inventors: LESLIE SIERAD, CHRISTOPHER DELANEY, RICHARD PASCAL, III, DAN SIMIONESCU, AGNETA SIMIONESCU
  • Patent number: 11034928
    Abstract: Bioreactors and components of bioreactors are described as may be beneficially utilized in development and conditioning of cellular materials for study or implant. The bioreactors are modular and components of the bioreactors can be easily assembled with alternatives provided to develop specific, predetermined conditioning environments for cellular materials (e.g., implantable tissue). By selection of one of multiple alternative compliance chambers, a bioreactor can be utilized to condition tissue in a low pressure circuit (e.g., a pulmonary heart circuit), and by utilization of an alternative compliance chamber, the bioreactor can instead condition tissue in a high pressure circuit (e.g., an aortic heart circuit).
    Type: Grant
    Filed: July 23, 2015
    Date of Patent: June 15, 2021
    Assignee: Clemson University Research Foundation
    Inventors: Leslie Sierad, Christopher Delaney, Richard Pascal, III, Dan Simionescu, Agneta Simionescu
  • Patent number: 10660754
    Abstract: Tissue holders that can be used for gripping natural or synthetic heart valves are described. The tissue holder can include a clamping mechanism and a spring and can be self-adjusting with regard to pressure applied to the tissue gripped in the holder. The tissue holder can be removably attached to systems for processing the tissues and can provide completely hands-free processing of a tissue from development or excisement to implantation and/or completion of testing.
    Type: Grant
    Filed: June 18, 2018
    Date of Patent: May 26, 2020
    Assignee: Clemson University Research Foundation
    Inventors: Leslie Sierad, Richard Pascal, III, Chris deBorde, Dan Simionescu, Agneta Simionescu
  • Publication number: 20180296342
    Abstract: Tissue holders that can be used for gripping natural or synthetic heart valves are described. The tissue holder can include a clamping mechanism and a spring and can be self-adjusting with regard to pressure applied to the tissue gripped in the holder. The tissue holder can be removably attached to systems for processing the tissues and can provide completely hands-free processing of a tissue from development or excisement to implantation and/or completion of testing.
    Type: Application
    Filed: June 18, 2018
    Publication date: October 18, 2018
    Inventors: Leslie Sierad, Richard Pascal, III, Chris deBorde, Dan Simionescu, Agneta Simionescu
  • Patent number: 10022225
    Abstract: Tissue holders that can be used for gripping natural or synthetic heart valves are described. The tissue holder can include a clamping mechanism and a spring and can be self-adjusting with regard to pressure applied to the tissue gripped in the holder. The tissue holder can be removably attached to systems for processing the tissues and can provide completely hands-free processing of a tissue from development or excisement to implantation and/or completion of testing.
    Type: Grant
    Filed: July 23, 2015
    Date of Patent: July 17, 2018
    Assignee: CLEMSON UNIVERSITY RESEARCH FOUNDATION
    Inventors: Leslie Sierad, Richard Pascal, Christopher deBorde, Dan Simionescu, Agneta Simionescu
  • Publication number: 20160024452
    Abstract: Bioreactors and components of bioreactors are described as may be beneficially utilized in development and conditioning of cellular materials for study or implant. The bioreactors are modular and components of the bioreactors can be easily assembled with alternatives provided to develop specific, predetermined conditioning environments for cellular materials (e.g., implantable tissue). By selection of one of multiple alternative compliance chambers, a bioreactor can be utilized to condition tissue in a low pressure circuit (e.g., a pulmonary heart circuit), and by utilization of an alternative compliance chamber, the bioreactor can instead condition tissue in a high pressure circuit (e.g., an aortic heart circuit).
    Type: Application
    Filed: July 23, 2015
    Publication date: January 28, 2016
    Inventors: Leslie Sierad, Christopher Delaney, Richard Pascal, III, Dan Simionescu, Agneta Simionescu
  • Publication number: 20160022420
    Abstract: Tissue holders that can be used for gripping natural or synthetic heart valves are described. The tissue holder can include a clamping mechanism and a spring and can be self-adjusting with regard to pressure applied to the tissue gripped in the holder. The tissue holder can be removably attached to systems for processing the tissues and can provide completely hands-free processing of a tissue from development or excisement to implantation and/or completion of testing.
    Type: Application
    Filed: July 23, 2015
    Publication date: January 28, 2016
    Inventors: Leslie Sierad, Richard Pascal, III, Christopher deBorde, Dan Simionescu, Agneta Simionescu
  • Publication number: 20080305232
    Abstract: The invention relates to a device for continuously mixing ingredients of a flour-and-water-based food dough comprising two mixing tools rotatably mounted one above the other about an axis of rotation, wherein the top tools is embodied in the form of a helix extending in a substantially perpendicular direction to said axis of rotation in such a way that the ingredient mixture is produced, the lower tool comprises at least one radial arm provided with a leading surface inclined with respect to the axis of rotation and an enclosure is provided with a mixed dough discharge opening which is arranged in the peripheral side part of a mixing space and in front of the lower tool.
    Type: Application
    Filed: October 5, 2007
    Publication date: December 11, 2008
    Inventors: Gerard Fisson, Laurent Jaunet, Richard Pascal