Abstract: The present invention relates to dihydro-cyclopenta-isoquinoline derivatives of formula (I): processes for preparing them, pharmaceutical compositions containing them and their use in treating disorders caused by IgE (such as allergic responses, non-allergic mast cell responses or certain autoimmune responses), and in particular, disorders caused by the interaction of IgE with the Fc?RI receptor.

Abstract: In various embodiments method are provided for generating expression cassettes and gene therapy vectors comprising those cassettes that recapitulate the spatiotemporal pattern of expression of the endogenous gene. In certain embodiments the methods comprise (i) selecting a target gene; (ii) identifying putative regulatory elements associated with the target gene; (iii) determining if the regulatory element is a key regulatory element and (iv) providing a list of the key regulatory elements identified in step (iii).

Abstract: A multi-tile processing unit in which the tiles in the processing unit may be divided between two or more different external sync groups for performing barrier synchronisations. In this way, different sets of tiles of the same processing unit each sync with different sets of tiles external to that processing unit.

Abstract: A tool interchange for a submersible remote operated vehicle (ROV) arm includes a first interchange body that affixes to an ROV arm. A second interchange body is carried by the first interchange body to rotate on a rotation axis. The second interchange body includes a tool mount actuable between gripping an ROV tool to the second interchange body and releasing the ROV tool from the second interchange body. An inductive power coupling part is provided in the tool mount. The inductive power coupling part is presented outwardly in the tool mount opposite the first interchange body, resides on the rotation axis and is fixed with respect to the first interchange body while the second interchange body rotates. The inductive power coupling part is adapted to inductively communicate power with a corresponding inductor power coupling part of the ROV tool when the ROV tool is docked in the tool mount.

Abstract: Provided herein are antibodies that bind to the alpha subunit of an IL-7 receptor (IL-7R?). Also provided are uses of these antibodies in therapeutic applications, such as treatment of inflammatory diseases. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain regions of the antibodies, and vectors comprising the polynucleotides.

Abstract: A sound pressure metrology instrument determines sound pressure from index of refraction and includes: a light source that produces source light; the optical cavity that: receives an acoustic field from the sound source; receives the source light from the light source; produces acoustic-modified light from the source light; and communicates the acoustic-modified light to the photodetector; the photodetector that receives the acoustic-modified light from the optical cavity, produces an acoustic-modified signal from the acoustic-modified light, and communicates the acoustic-modified signal to the analyzer module; the analyzer module in electrical communication with the photodetector and that receives the acoustic-modified signal from the photodetector and determines the sound pressure of the acoustic field produced by the sound source from the modulations in the index of refraction of the acoustic medium inside the optical cavity encoded in the acoustic-modified light.

Abstract: In one embodiment, a method includes identifying at a first powered device in communication with power sourcing equipment, a second powered device in communication with the first powered device, wherein the first powered device is receiving high voltage pulse power from the power sourcing equipment, notifying the power sourcing equipment of the second powered device at the first powered device, and performing a low voltage power initialization at the first powered device with the second powered device before passing the high voltage pulse power to the second powered device.

Abstract: Filter elements, filter mounting systems, filter systems, methods of servicing filter systems, and methods of mounting filter elements are provided herein. The mounting system may include a quick attach attachment member that can be both axially slid along a mounting shank as well as threadedly engaged therewith. Torque limiting features may be provided to limit the amount of loading that may be provided by an attachment member to a filter element. Identifiers of appropriate tightening of attachment members may be provided. Clocking features and mechanisms for better balancing loading on seal members may be provided.

Abstract: A method comprises providing, via a server, access to a claim wall for an insured party and an insuring party, wherein the claim wall comprises a website page associated with an insurance claim, wherein the website page includes an interface configured to receive input from at least one of the insured party or the insuring party, wherein the website page displays one or more tasks associated with the insurance claim, and wherein the claim wall is configured to be output to a user interface as one or more entries on the website page; receiving, via the server, information that a status of the one or more tasks has changed; and populating an entry of the claim wall with status information regarding the status change of the one or more tasks.

Abstract: A wet wipe is provided. The wet wipe includes a sheet formed from non-plastic materials. The sheet has a weight of between 40-90 gsm. The sheet comprises a blend of wood pulp fluff fiber and cellulosic staple fibers and/or cross-linked curly pulp. The wood pulp fluff fiber has a weight percent of between 60-95%. The cellulosic staple fibers and/or cross-linked curly pulp has a weight percent of between 40-5%. A plastic free binder is included. The sheet has an effective wet strength of at least 150 grams per linear inch in the cross-direction.

Abstract: Disclosed is a platform that manages worker users in a temporary staffing environment via an artificial machine learning model. The temporary staffing platform matches available workers to available shifts/gigs. Additional features include generating provisional or near-miss matches and informing workers how to turn those near-misses into full matches, plotting a gig-career path to develop additional skills, gamify development, and automatically generate resumes. The platform generates a set of skill tags associated with each shift/gig performed by the user. Designing of resume text files by the artificial machine learning model includes procedurally generated descriptions of experience the a user has based on the recording of each shift/gig performed by the user and the skill tags associated with each recorded shift/gig, wherein a format of the resume text file is formulated by the artificial machine learning model evaluating a mix of skill tags and employers amassed by the user.

Abstract: A dispenser head for in-line mixing and dispensing of beverages, which may be carbonated or nitrogenated. The dispenser head comprising a pump, a dilution mechanism, an additive mechanism, and outlet nozzle and optionally a regulation system. In use, the pump can pump concentrate liquid for the liquid product from a concentrate source to the dilution mechanism; the dilution mechanism can receive diluent liquid suitable for the liquid product from a diluent source, operable to mix the diluent liquid and the concentrate liquid and provide diluted concentrate liquid; and the additive mechanism can receive additive fluid for the liquid product from an additive source, to combine the diluted concentrate liquid and the additive fluid.

Abstract: Various embodiments of the present technology relate to systems and methods for orchestrating workflows to operate multi-site datacenters based on energy and cloud-computing supply and demand. In an embodiment, a method of operating a datacenter orchestration engine is provided. The method comprises, on a per-tenant basis, obtaining, via one or more machine learning models, at least a real-time utilization of energy grids and an energy supply of the energy grids available for use by datacenters over a period of time; obtaining, via the one or more machine learning models, a cloud-computing demand projected for the datacenters during the period of time; generating a cloud-computing optimization plan based at least on the real-time utilization of the energy grids, the available energy supply, and the cloud-computing demand; and providing the cloud-computing optimization plan to one or more tenants in a multi-tenant environment.

Abstract: Disclosed is a platform that manages worker users in a temporary staffing environment via an artificial machine learning model. The temporary staffing platform matches available workers to available shifts/gigs. Additional features include generating provisional or near-miss matches and informing workers how to turn those near-misses into full matches, plotting a gig-career path to develop additional skills, gamify development, and automatically generate resumes. The platform generates a set of skill tags associated with each shift/gig performed by the user. Designing of resume text files by the artificial machine learning model includes procedurally generated descriptions of experience the a user has based on the recording of each shift/gig performed by the user and the skill tags associated with each recorded shift/gig, wherein a format of the resume text file is formulated by the artificial machine learning model evaluating a mix of skill tags and employers amassed by the user.

Abstract: An electronic system comprising: at least one user interface member configured to be manipulated by a user for performing a dose setting operation of the drug delivery device and/or for performing a dose delivery operation for delivering a set dose, an electronic control unit configured to control operation of the electronic system, an electrical signaling unit configured to provide at least one electrical signal when the user interface member is manipulated, and a manipulation evaluation unit configured to evaluate the at least one electrical signal of the signaling unit to determine whether the manipulation of the user interface member indicated by the at least one signal of the signaling unit qualifies as an activation operation. The electronic control unit is configured to switch the electronic system into a higher power consumption when the manipulation evaluation unit has confirmed that the manipulation qualifies as activation operation.

Abstract: Described herein are apparatuses and methods for dyeing garments. An exemplary apparatus comprises a dye injection system configured to dispense concentrated liquid dye; a dyeing machine comprising a dyeing chamber configured for dyeing at least one garment in a dyebath; and a controller in communication with the dye injection system and the dyeing machine, wherein the controller is configured: to receive at least one garment parameter corresponding to the at least one garment; based at least in part on the at least one received garment parameter, cause the dye injection system to dispense a volume of concentrated liquid dye containing an amount of dyestuff that can be substantially absorbed by the at least one garment; and cause the dyeing machine to execute a dye cycle such that substantially all of the dyestuff in the dispensed concentrated liquid dye is absorbed by the at least one garment within the dyeing chamber.

Abstract: Disclosed is a platform that manages worker users in a temporary staffing environment via an artificial machine learning model. The temporary staffing platform matches available workers to available shifts/gigs. Additional features include generating provisional or near-miss matches and informing workers how to turn those near-misses into full matches, plotting a gig-career path to develop additional skills, gamify development, and automatically generate resumes. The platform generates a set of skill tags associated with each shift/gig performed by the user. Designing of resume text files by the artificial machine learning model includes procedurally generated descriptions of experience the a user has based on the recording of each shift/gig performed by the user and the skill tags associated with each recorded shift/gig, wherein a format of the resume text file is formulated by the artificial machine learning model evaluating a mix of skill tags and employers amassed by the user.

Abstract: A system and method of creating customized characters and selectively displaying them in an electronic display, such as an augmented reality or virtual reality display is provided. A digital character may be provided by a character provider for customization by others using the system. Such customizations may be instantiated in user devices that provide electronic displays. Instantiation of the custom digital character may be conditioned on one or more trigger conditions, which may be specified by the character customizer. For example, a digital character customized using the system may be conditioned on triggering events in the real-world or in a virtual world. When a relevant triggering condition is satisfied at a user device, the custom character (i.e., information for instantiating the custom character) may be transmitted to that user device. In this manner, the system may push custom characters to user devices that satisfy the triggering condition.