Patents by Inventor Richard Premont

Richard Premont has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NICLOSAMIDE-CONJUGATED POLYPEPTIDE NANOPARTICLES
    Publication number: 20190083638
    Abstract: Disclosed herein are conjugates of a therapeutic compound and polypeptides, such as a conjugate of niclosamide and an elastin-like polypeptide. These conjugates may form nanoparticles through self-assembly, which improve the solubility, bioavailability, and pharmacokinetic profiles of the therapeutic compound. Also disclosed are methods for treating cancer, parasite infection, bacterial infection, viral infection, metabolic diseases, Type II diabetes, NASH, NAFLD, artery constriction, endometriosis, neuropathic pain, rheumatoid arthritis, sclerodermatous graft-versus-host disease, and systemic sclerosis.
    Type: Application
    Filed: July 25, 2018
    Publication date: March 21, 2019
    Inventors: Wei Chen, Jayanta Bhattacharyya, Xiu-Rong Ren, Robert A. Mook, Jiangbo Wang, Ivan Spasojevic, Richard Premont, Xinghai Li, Ashutosh Chilkoti
  • Methods of screening compounds for GRK6 modulating activity
    Publication number: 20060029983
    Abstract: The present invention relates to methods of treating disease by altering G protein coupled receptor kinase (GRK) 6. This may be done by altering the expression or activity of the protein, for example. The present invention may be used for disease diagnosis, by detecting the expression or activity of GRK6. The present invention relates to a GRK6 deficient mouse, GRK6 splice variants, and methods of use. The present invention also relates to methods of identifying compounds that alter GRK6 activity. The present invention relates to disease treatment by altering GRK6 expression or activity.
    Type: Application
    Filed: January 21, 2005
    Publication date: February 9, 2006
    Inventors: Robert Oakley, Christine Hudson, Marc Caron, Raul Gainetdinov, Robert Lefkowitz, Richard Premont