Patents by Inventor Richard R. Kleszynski

Richard R. Kleszynski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Preparation of factor IX
    Patent number: 6280729
    Abstract: A novel method of protecting blood coagulation factor IX from proteases during purification or storage is disclosed. High concentrations of one or more water soluble organic or inorganic salts are used to stabilize factor IX, contained within blood plasma-derived solutions, or contained within solutions derived from other sources, against conversion to clinically unacceptable peptide structures such as factor IXa, and/or degraded factor IX peptides. The technique is useful in stabilizing intermediate purity factor IX preparations during purification, and in maintaining the integrity of purified factor IX during long term storage. Stable high specific activity factor IX preparations are also disclosed.
    Type: Grant
    Filed: March 13, 2000
    Date of Patent: August 28, 2001
    Assignee: Aventis Behring LLC
    Inventors: Chin C. Huang, Takashi Enkoji, Laura Ho, Richard R. Kleszynski, Richard L. Weeks, Fred Feldman
  • Preparation of factor IX
    Patent number: 6063909
    Abstract: A novel method of protecting blood coagulation factor IX from proteases during purification or storage is disclosed. High concentrations of one or more water soluble organic or inorganic salts are used to stabilize factor IX, contained within blood plasma-derived solutions, or contained within solutions derived from other sources, against conversion to clinically unacceptable peptide structures such as factor IX.sub.a, and/or degraded factor IX peptides. The technique is useful in stabilizing intermediate purity factor IX preparations during purification, and in maintaining the integrity of purified factor IX during long term storage. Stable high specific activity factor IX preparations are also disclosed.
    Type: Grant
    Filed: August 3, 1993
    Date of Patent: May 16, 2000
    Assignee: Aventis Behring L.L.C.
    Inventors: Chin C. Huang, Enkoji Takashi, Laura Ho, Richard R. Kleszynski, Richard L. Weeks, Fred Feldman
  • Preparation of factor IX
    Patent number: 6043215
    Abstract: A novel method of protecting blood coagulation factor IX from proteases during purification or storage is disclosed. High concentrations of one or more water soluble organic or inorganic salts are used to stabilize factor IX, contained within blood plasma-derived solutions, or contained within solutions derived from other sources, against conversion to clinically unacceptable peptide structures such as factor IX.sub.a, and/or degraded factor IX peptides.The technique is useful in stabilizing intermediate purity factor IX preparations during purification, and in maintaining the integrity of purified factor IX during long term storage. Stable high specific activity factor IX preparations are also disclosed.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: March 28, 2000
    Assignee: Aventis Behring L.L.C.
    Inventors: Chin C. Huang, Takashi Enkoji, Laura Ho, Richard R. Kleszynski, Richard L. Weeks, Fred Feldman