Abstract: A transdermal patch assembly includes a pressure sensitive carrier having a central opening, one side being provided with a clear liner thereon extending across the central opening, and an opposite side being provided with a first adhesive coating thereon, the carrier having a thickness such that when combined with the clear liner, a cell is defined by walls of the central opening and an inwardly facing surface of the clear liner, the cell holding a pharmaceutical composition therein. The transdermal patch also includes a pharmaceutical diffusing cover having an overlying side with an outer periphery attached by the first adhesive coating to an inner periphery of the carrier opposite side, and an underlying side having a pair of opposed portions attached to a peelable release liner removably secured to an outer periphery of the carrier opposite side by the first adhesive coating.