Abstract: The present invention relates to peptides, in particular cell-penetrating peptides, and to conjugates of such cell-penetrating peptides with a therapeutic molecule. The present invention further relates to use of such peptides or conjugates in methods of treatment or as a medicament, especially in the treatment of genetic disorders and in particular muscular dystrophies such as Duchenne muscular dystrophy.

Abstract: Disclosed are conjugates of an oligonucleotide and a peptide covalently bonded or linked via a linker to the oligonucleotide, the peptide including at least one cationic domain comprising at least 4 amino acid residues and at least one hydrophobic domain comprising at least 3 amino acid residues, provided that the peptide includes a total of 7 to 40 amino acid residues and does not include any artificial amino acid residues; and the oligonucleotide including a total of 12 to 40 contiguous nucleobases, where at least 12 contiguous nucleobases are complementary to a target sequence in a human dystrophin gene.

Abstract: The present invention relates to conjugates formed from a cell-penetrating peptide carrier linked to a therapeutic molecule, wherein the peptide carrier is defined by specific domains and the therapeutic molecule is a nucleic acid formed of trinucleotide repeats. The present invention further relates to the use of such a conjugate in methods of treatment or as a medicament, especially in the treatment of trinucleotide repeat disorders such as myotonic dystrophy (DM1).

Abstract: The present invention relates to linkers for connecting a carrier molecule to a therapeutic molecule to form a conjugate, in particular linkers formed of amino acids such as glutamic acid, succinic acid, and gamma-aminobutyric acid. The present invention further relates to a conjugate comprising a linker of the invention, and the use of said conjugate in the treatment of various diseases.

Abstract: The present invention relates to peptides, in particular cell-penetrating peptides, and to conjugates of such cell-penetrating peptides with a therapeutic molecule. The present invention further relates to use of such peptides or conjugates in methods of treatment or as a medicament, especially in the treatment of genetic disorders and in particular muscular dystrophies such as Duchenne muscular dystrophy.

Abstract: the present invention relates to peptides, in particular cell-penetrating peptides, having a first hydrophobic domain positioned at the C-terminus of the peptide and a second hydrophobic domain positioned at the N-terminus of the peptide, and to conjugates of such cell-penetrating peptides with a therapeutic molecule. The present invention further relates to use of such peptides or conjugates in methods of treatment or as a medicament, especially in the treatment of genetic disorders and in particular muscular dystrophies such as Duchenne muscular dystrophy.

Abstract: A slide valve assembly is provided for selectively dispensing dry goods from a hopper. The slide valve assembly is readily attached and detached from the hopper and is readily disassembled and reassembled to facilitate cleaning and/or servicing. Preferably, the slide valve assembly includes a panel secured to spaced support rails, a movable valve panel for opening and closing of the dispensing portion of the hopper, and a collar retainer for releasable attachment to the dispensing portion of a hopper. The slide valve assembly may be attached, detached, assembled, and disassembled substantially without the use of tools or separate fasteners, to minimize the risk of creating a contamination hazard for the goods dispensed from the hopper, while still allowing for secure attachment to the hopper.

Abstract: A slide valve assembly is provided for selectively dispensing dry goods from a hopper. The slide valve assembly is readily attached and detached from the hopper and is readily disassembled and reassembled to facilitate cleaning and/or servicing. Preferably, the slide valve assembly includes a panel secured to spaced support rails, a movable valve panel for opening and closing of the dispensing portion of the hopper, and a collar retainer for releasable attachment to the dispensing portion of a hopper. The slide valve assembly may be attached, detached, assembled, and disassembled substantially without the use of tools or separate fasteners, to minimize the risk of creating a contamination hazard for the goods dispensed from the hopper, while still allowing for secure attachment to the hopper.

Abstract: A bulk container and method of use for storage of at least two substances includes a first container for containing a first substance, and a second container for containing a second substance. The first container has an outer surface including a recess, and the second container has a shape corresponding with the recess of the first container. The second container is coupled with the recess to form a container assembly. The first substance and second substance are kept separate when in the first and second containers respectively.