Patents by Inventor Richard Remmele

Richard Remmele has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Increased recovery of active proteins
    Publication number: 20070270577
    Abstract: The invention provides methods of increasing yields of desired conformation of proteins. In particular embodiments, the invention includes contacting preparations of a recombinant protein with a reduction/oxidation coupling reagent for a time sufficient to increase the relative proportion of a desired configurational isomer.
    Type: Application
    Filed: November 22, 2006
    Publication date: November 22, 2007
    Inventors: Helmut Sassenfeld, Richard Remmele, Rebecca McCoy
  • Polypeptide formulation
    Publication number: 20070243185
    Abstract: The present invention relates to an aqueous pharmaceutical composition suitable for long-term storage of polypeptides containing an Fc domain of an immunoglobulin, methods of manufacture, methods of administration and kits containing same.
    Type: Application
    Filed: April 6, 2007
    Publication date: October 18, 2007
    Inventors: Wayne Gombotz, Richard Remmele
  • Method And Apparatus For Predicting Aggregation Kinetics Of A Biologically Active Material
    Publication number: 20070212678
    Abstract: A mechanistic model was developed to extract meaningful thermodynamic and kinetic parameters from an irreversibly denatured process. As a result, methods and computer apparatus have been created that can be used to mathematically determine parameters that are predictive of aggregation kinetics of biologically active materials. Those parameters can then be used to predict stability or aggregation kinetics as a function of time and temperature.
    Type: Application
    Filed: April 22, 2005
    Publication date: September 13, 2007
    Applicant: AMGEN INC.
    Inventors: Richard Remmele Jr, David Balaban, Jian Zhang, Alexander Shoshitaishvili, Mark Durst