Abstract: Methods and products for suppressing a class II MHC-restricted immune response in a mammal, or in mammalian cells, are described. The methods depend upon inhibiting invariant chain proteolysis by cathepsin S from class II MHC/invariant chain complexes, thereby reducing the competency of class II MHC molecules for binding antigenic peptides, reducing presentation of antigenic peptides by class II MHC molecules, and suppressing immune responses. The methods may be employed in the treatment of autoimmune diseases, allergic responses, and organ or tissue graft rejection. Pharmaceutical and therapeutic compositions which are peptide based inhibitors of cathepsin S are also described.

Abstract: Methods and products for suppressing a class II MHC-restricted immune response in a mammal, or in mammalian cells, are described. The methods depend upon inhibiting invariant chain proteolysis by cathepsin S from class II MHC/invariant chain complexes, thereby reducing the competency of class II MHC molecules for binding antigenic peptides, reducing presentation of antigenic peptides by class II MHC molecules, and suppressing immune responses. The methods may be employed in the treatment of autoimmune diseases, allergic responses, and organ or tissue graft rejection. Pharmaceutical and therapeutic compositions which are peptide based inhibitors of cathepsin S are also described.

Abstract: A specimen, sample collection and transport container comprising a flexible plastic bag which is separated into selectively sealed chambers by leak-proof interlocking, multiple track, reclosable fasteners. The bag comprises a sheet of coextruded polyethylene-Saran-polyethelene material which is folded in half and sealed at the side edges. An interior fastener substantially traverses the container parallel to the folded bottom, thereby defining a lower chamber. An entrance fastener is affixed to the upper edges to selectively seal the entrance. Gripper flaps are added to the exterior of the container to facilitate the opening of the interior fastener. The lower chamber is supplied with a fixative or transport solution which is introduced by clipping or puncturing the lower corner or edge of the bag. The corner or hole is then sealed.