Abstract: The specification relates to compounds of Formula (I) and pharmaceutically acceptable salts thereof. The specification also relates to processes and intermediates used for their preparation, pharmaceutical compositions containing them and their use in the treatment of cell proliferative disorders.

Abstract: The specification relates to compounds of Formula (I) and pharmaceutically acceptable salts thereof. The specification also relates to processes and intermediates used for their preparation, pharmaceutical compositions containing them and their use in the treatment of cell proliferative disorders.

Abstract: The specification relates to compounds of Formula (I) and pharmaceutically acceptable salts thereof. The specification also relates to processes and intermediates used for their preparation, pharmaceutical compositions containing them and their use in the treatment of cell proliferative disorders.

Abstract: The specification relates to compounds of Formula (I): and pharmaceutically acceptable salts thereof. The specification also relates to processes and intermediates used for their preparation, pharmaceutical compositions containing them and their use in the treatment of cell proliferative disorders.

Abstract: The specification relates to compounds of Formula (I) and pharmaceutically acceptable salts thereof. The specification also relates to processes and intermediates used for their preparation, pharmaceutical compositions containing them and their use in the treatment of cell proliferative disorders.

Abstract: The specification relates to compounds of Formula (I) and pharmaceutically acceptable salts thereof. The specification also relates to processes and intermediates used for their preparation, pharmaceutical compositions containing them and their use in the treatment of cell proliferative disorders.

Abstract: The specification relates to compounds of Formula (I) and pharmaceutically acceptable salts thereof. The specification also relates to processes and intermediates used for their preparation, pharmaceutical compositions containing them and their use in the treatment of cell proliferative disorders.

Abstract: The specification relates to compounds of Formula (I) and pharmaceutically acceptable salts thereof. The specification also relates to processes and intermediates used for their preparation, pharmaceutical compositions containing them and their use in the treatment of cell proliferative disorders.

Abstract: A method, a statistics subsystem, and a system use a combination of commercially available high speed memory and high density low speed memory to mitigate cost, space, control, and power issues associated with storing counters for statistics updates, while meeting the growing width and depth needs of multi-hundred gigabit Carrier Class data network devices. The method, statistics subsystem, and system offer a Counter Management Algorithm (CMA) that relies on rollover bits stored within data of counters. An update to the low speed memory is substantially faster than a rollover time for the counter in the high speed memory thereby allowing statistics to be cached in the high speed memory while updates take place to the low speed memory.

Abstract: A system for management of multimedia content having a processor and memory configured to execute software instructions for implementing a content management component operative to upload the multimedia content and to create at least one compilation from the multimedia content, a market management component operative to assign market-specific data to the compilation, and a store builder resource component operative to generate one or more online stores for promotion of the compilation having the assigned market-specific data.

Abstract: A compound of formula I or a pharmaceutically acceptable salt thereof in which R1, R2, R3, R4 and m are as described in the specification for use in the treatment of obesity and/or diabetes.

Abstract: A compound of Formula (I): is useful in the treatment or prevention of a disease or medical condition mediated through glucokinase (GLK or GK), leading to a decreased glucose threshold for insulin secretion.

Abstract: A system for management of multimedia content having a processor and memory configured to execute software instructions for implementing a content management component operative to upload the multimedia content and to create at least one compilation from the multimedia content, a market management component operative to assign market-specific data to the compilation, and a store builder resource component operative to generate one or more online stores for promotion of the compilation having the assigned market-specific data.

Abstract: A compound of formula I or a pharmaceutically acceptable salt thereof in which R1, R2, R3, R4 and m are as described in the specification for use in the treatment of obesity and/or diabetes.

Abstract: A compound of Formula (I): is useful in the treatment or prevention of a disease or medical condition mediated through glucokinase (GLK or GK), leading to a decreased glucose threshold for insulin secretion.

Abstract: A compound of formula I or a pharmaceutically acceptable salt thereof in which R1, R2, R3, R4 and m are as described in the specification for use in the treatment of obesity and/or diabetes.

Abstract: Compounds of Formula (I): wherein R1 to R11, A and X1 to X3 are as described in the specification, and their salts, are activators of glucokinase (GLK) and are thereby useful in the treatment of, for example, type 2 diabetes. Processes for preparing compounds of Formula (I) are also described.

Abstract: The present invention is directed to an improved system and method for auctioning services, which overcomes some of the drawbacks in the prior art systems and methods. In accordance with one aspect of the present invention, buyers request and specify at the start of the auction the number of lowest bids the buyers would like to see. By requesting to see more bids, the buyers would have greater opportunity to evaluate service providers based on factors other than price, thereby encouraging less price competition among providers. By requesting to see fewer bids, the buyers would have less opportunity to evaluate service providers based on factors other than price, thereby encouraging fierce price competition. The number of bids requested by the Buyer is made known to the bidders. The net effect is that the buyers can control the price/quality tradeoff at the onset of the auction process, and encourage the bidders to provide their lowest bids when pricing is important.

Abstract: A system and method for auctioning services. A rating system is employed to rate the buyer's transaction history, with respect to their frequency of following through with the bids for jobs that they submitted for auction. This rating system deters those buyers that casually shop for pricing with little chance of following through with the auction. A low rating discourages service providers from bidding, thereby decreasing the competitiveness of an auction and increasing the cost of obtaining the service. The buyer follow-through ratings give the bidders a better sense of the buyer's commitment prior to deciding on allocating resources to participate in bidding at the auction. In one embodiment, the system and method for auctioning services are implemented over an information exchange network. In a further aspect, buyers request and specify at the start of the auction the number of lowest bids the buyers would like to see.

Abstract: Techniques for generating tissue support structure are presented. A curved minimal surface shape is determined as a template for generating a tissue support structure. The determined curved minimal surface shape is numerically or functionally defined to create data representing the shape. The data is exported to a rapid prototyping system to generate a plurality of tissue support structures having a curved minimal surface. The tissue support structure can have a pore sub-section and a non-pore sub-section divided by a non-intersecting two-sided surface. A number of characteristics of the tissue support structure can be modulated including porosity and mechanical strength.