Abstract: A substantially non-reflective, low or non-fluorescing substrate comprising a phase-inversion support and a plurality of opaque solids that are substantially chemically non-reactive with the phase inversion support and of a size sufficient to be partially or completely contained within, or intimately bound to, the phase inversion support. Methods of making and using the substantially non-reflective, low or non-fluorescing substrate are also disclosed.

Abstract: A microporous membrane comprising a highly electropositive hydrophilic material capable of irreversibly binding one or more nucleic acids, the membrane being useful for isolating, amplifying and detecting nucleic acids is disclosed. Methods of making the membrane and using the membrane for amplifying nucleic acids are also disclosed.

Abstract: Disclosed herein is a novel multi-layered, composite microporous membrane comprising in at least one layer a highly electropositive hydrophilic material distributed throughout wherein the material is capable of irreversibly binding nucleic acid and, optionally, at least one layer where the material is associated with sequence-specific peptide nucleic acids, permitting the simultaneous or sequential capture, amplification and/or identification of specific nucleic acid sequences of interest. Also disclosed herein are methods of use of the composite membranes of the invention in applications based on the sequence-specific capture and/or amplification and identification of nucleic acid from complex biological samples.

Abstract: A microporous membrane comprising a highly electropositive hydrophilic material capable of irreversibly binding one or more nucleic acids, the membrane being useful for isolating, amplifying and detecting nucleic acids is disclosed. Methods of making the membrane and using the membrane for amplifying nucleic acids are also disclosed.

Abstract: A substantially non-reflective, low or non-fluorescing substrate comprising a phase-inversion support and a plurality of opaque solids that are substantially chemically non-reactive with the phase inversion support and of a size sufficient to be partially or completely contained within, or intimately bound to, the phase inversion support. Methods of making and using the substantially non-reflective, low or non-fluorescing substrate are also disclosed.