Patents by Inventor Richard S. Fornicola

Richard S. Fornicola has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Purification of rapamycin derivatives using temperature induced phase separation
    Patent number: 11780850
    Abstract: The present invention provides methods for obtaining purified rapamycin derivatives, including purified Biolimus A9. A crystalline form of Biolimus A9 is also described.
    Type: Grant
    Filed: June 28, 2021
    Date of Patent: October 10, 2023
    Assignee: Biosensors International Group, Ltd.
    Inventors: Margaret W. Kayo, Richard S. Fornicola, Ivan Kovacik, Leelakrishna Kondaveti, Aniruddh Singh
  • Purification of Rapamycin Derivatives Using Temperature Induced Phase Separation
    Publication number: 20220024947
    Abstract: The present invention provides methods for obtaining purified rapamycin derivatives, including purified Biolimus A9. A crystalline form of Biolimus A9 is also described.
    Type: Application
    Filed: June 28, 2021
    Publication date: January 27, 2022
    Inventors: Margaret W. Kayo, Richard S. Fornicola, Ivan Kovacik, Leelakrishna Kondaveti, Aniruddh Singh
  • Purification of rapamycin derivatives using temperature induced phase separation
    Patent number: 11046711
    Abstract: The present invention provides methods for obtaining purified rapamycin derivatives, including purified Biolimus A9. A crystalline form of Biolimus A9 is also described.
    Type: Grant
    Filed: March 2, 2020
    Date of Patent: June 29, 2021
    Assignee: Biosensors International Group, Ltd.
    Inventors: Margaret W. Kayo, Richard S. Fornicola, Ivan Kovacik, Leelakrishna Kondaveti, Aniruddh Singh
  • PURIFICATION OF RAPAMYCIN DERIVATIVES USING TEMPERATURE INDUCED PHASE SEPARATION
    Publication number: 20200270272
    Abstract: The present invention provides methods for obtaining purified rapamycin derivatives, including purified Biolimus A9. A crystalline form of Biolimus A9 is also described.
    Type: Application
    Filed: March 2, 2020
    Publication date: August 27, 2020
    Inventors: Margaret W. Kayo, Richard S. Fornicola, Ivan Kovacik, LeelaKrishna Kondaveti, Aniruddh Singh
  • Purification of rapamycin derivatives using temperature induced phase separation
    Patent number: 10597406
    Abstract: The present invention provides methods for obtaining purified rapamycin derivatives, including purified Biolimus A9. A crystalline form of Biolimus A9 is also described.
    Type: Grant
    Filed: December 18, 2018
    Date of Patent: March 24, 2020
    Assignee: Biosensors International Group, Ltd.
    Inventors: Margaret W. Kayo, Richard S. Fornicola, Ivan Kovacik, Leelakrishna Kondaveti, Aniruddh Singh
  • Purification of Rapamycin Derivatives Using Temperature Induced Phase Separation
    Publication number: 20190256527
    Abstract: The present invention provides methods for obtaining purified rapamycin derivatives, including purified Biolimus A9. A crystalline form of Biolimus A9 is also described.
    Type: Application
    Filed: December 18, 2018
    Publication date: August 22, 2019
    Inventors: Margaret W. Kayo, Richard S. Fornicola, Ivan Kovacik, Leelakrishna Kondaveti, Aniruddh Singh
  • Purification of rapamycin derivatives using temperature induced phase separation
    Patent number: 10202402
    Abstract: The present invention provides methods for obtaining purified rapamycin derivatives, including purified Biolimus A9. A crystalline form of Biolimus A9 is also described.
    Type: Grant
    Filed: February 2, 2017
    Date of Patent: February 12, 2019
    Assignee: Biosensors International Group, Ltd.
    Inventors: Margaret W. Kayo, Richard S. Fornicola, Ivan Kovacik, Leelakrishna Kondaveti, Aniruddh Singh
  • Purification of Rapamycin Derivatives Using Temperature Induced Phase Separation
    Publication number: 20170334928
    Abstract: The present invention provides methods for obtaining purified rapamycin derivatives, including purified Biolimus A9. A crystalline form of Biolimus A9 is also described.
    Type: Application
    Filed: February 2, 2017
    Publication date: November 23, 2017
    Inventors: Margaret W. Kayo, Richard S. Fornicola, Ivan Kovacik, Leelakrishna Kondaveti, Aniruddh Singh
  • Purification of rapamycin derivatives using temperature induced phase separation
    Patent number: 9598439
    Abstract: The present invention provides methods for obtaining purified rapamycin derivatives, including purified Biolimus A9. A crystalline form of Biolimus A9 is also described.
    Type: Grant
    Filed: September 14, 2015
    Date of Patent: March 21, 2017
    Assignee: BIOSENSORS INTERNATIONAL GROUP, LTD.
    Inventors: Margaret W. Kayo, Richard S. Fornicola, Ivan Kovacik, Leelakrishna Kondaveti, Aniruddh Singh
  • Low temperature synthesis of rapamycin derivatives
    Patent number: 9434744
    Abstract: The present invention provides improved processes for obtaining rapamycin derivatives including Biolimus A9.
    Type: Grant
    Filed: July 21, 2015
    Date of Patent: September 6, 2016
    Assignee: Biosensors International Group, Ltd.
    Inventors: Margaret W. Kayo, Richard S. Fornicola, Ivan Kovacik
  • PURIFICATION OF RAPAMYCIN DERIVATIVES USING TEMPERATURE INDUCED PHASE SEPARATION
    Publication number: 20160002262
    Abstract: The present invention provides methods for obtaining purified rapamycin derivatives, including purified Biolimus A9. A crystalline form of Biolimus A9 is also described.
    Type: Application
    Filed: September 14, 2015
    Publication date: January 7, 2016
    Inventors: MARGARET W. KAYO, RICHARD S. FORNICOLA, IVAN KOVACIK, LEELAKRISHNA KONDAVETI, ANIRUDDH SINGH
  • LOW TEMPERATURE SYNTHESIS OF RAPAMYCIN DERIVATIVES
    Publication number: 20150322086
    Abstract: The present invention provides improved processes for obtaining rapamycin derivatives including Biolimus A9.
    Type: Application
    Filed: July 21, 2015
    Publication date: November 12, 2015
    Inventors: MARGARET W. KAYO, RICHARD S. FORNICOLA, IVAN KOVACIK
  • Dipeptidyl peptidase inhibitors
    Patent number: 8222411
    Abstract: Methods of making compounds of the formula (I) wherein the variables are as defined herein. Also, methods of making compounds that may be used to inhibit dipeptidyl peptidase.
    Type: Grant
    Filed: September 15, 2006
    Date of Patent: July 17, 2012
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Jun Feng, Stephen L. Gwaltney, Jeffrey A. Stafford, Zhiyuan Zhang, Paul R. Brodfuahrer, Bruce Elder, Paul Isbester, Richard S. Fornicola, Philip B. Kisanga, Bingidimi I. Mobele, Grant J. Palmer, Maxwell M. Reeve, Jonathon S. Salsbury, Luckner Ulysse, Sripathy Venkatraman
  • PREPARATION OF (R)-3-AMINOPIPERIDINE DIHYDROCHLORIDE
    Publication number: 20100029941
    Abstract: Described herein are methods for making chiral derivatives of 3-aminopiperidine, including the production of such derivatives in quantities exceeding 1 kilogram. The chiral 3-aminopiperidine derivatives include (R)-3-aminopiperidine derivatives which may be used to synthesize inhibitors of Dipeptidyl Peptidase IV. (R)-3-Aminopiperidine dihydrochloride is prepared by reducing (R)-3-aminopiperidin-2-one hydrochloride with lithium aluminum hydride. The preparation of (R)-3-aminopiperidin-2-one hydrochloride starting from (R)-methyl-2,5-diaminopentanoate dihydrochloride or (R)-2,5-diaminopentanoic acid hydrochloride is also described.
    Type: Application
    Filed: March 26, 2007
    Publication date: February 4, 2010
    Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
    Inventors: Michael B. Wallace, Jeremy Cody, Richard S. Fornicola, Silvina Garcia-Rubio, Philip B. Kisanga, Maxwell D. Reeve, Chandra Wilson
  • DIPEPTIDYL PEPTIDASE INHIBITORS
    Publication number: 20090275750
    Abstract: Methods of making compounds of the formula (I) wherein the variables are as defined herein. Also, methods of making compounds that may be used to inhibit dipeptidyl peptidase.
    Type: Application
    Filed: September 15, 2006
    Publication date: November 5, 2009
    Inventors: Jun Feng, Stephen L. Gwaltney, Jeffrey A. Stafford, Zhiyuan Zhang, Paul R. Brodluahrer, Bruce Elder, Paul Isbester, Richard S. Fornicola, Philip B. Kisanga, Bingidimi I. Mobele, Grant J. Palmer, Maxwell M. Reeve, Jonathon S. Salsbury, Luckner Ulysse, Sripathy Venkatraman