Abstract: A apparatus for automatically detecting a pregnancy status of a patient include a patch for adhering to human skin, a uterine contraction sensor, such as electromyography (EMG), coupled to the patch with at least two electrodes, and an inertial sensor for sensing fetal movement, or Fetal Heart Rate (FHR) sensor, such as Fetal EKG or a Doppler Ultrasound. An electronic circuit is coupled to the patch, the EMG sensor and the inertial sensor, and/or FHR sensor. The circuit provides an output based on a uterine contraction signal from the EMG sensor (or Doppler ultrasound) correlated in time to a fetal movement, and/or fetal heart rate. The apparatus may include a thermometer to aid in automatically providing an indication of a pregnancy complication or ovulation status of the patient, based on the output.

Abstract: Methods for quantitatively determining a binding kinetic parameter of a molecular binding interaction are provided. Aspects of embodiments of the methods include: producing a magnetic sensor device including a magnetic sensor in contact with an assay mixture including a magnetically labeled molecule to produce a detectable molecular binding interaction; obtaining a real-time signal from the magnetic sensor; and quantitatively determining a binding kinetics parameter of the molecular binding interaction from the real-time signal. Also provided are systems and kits configured for use in the methods.

Abstract: A apparatus for automatically detecting a pregnancy status of a patient include a patch for adhering to human skin, a uterine contraction sensor, such as electromyography (EMG), coupled to the patch with at least two electrodes, and an inertial sensor for sensing fetal movement, or Fetal Heart Rate (FHR) sensor, such as Fetal EKG or a Doppler Ultrasound. An electronic circuit is coupled to the patch, the EMG sensor and the inertial sensor, and/or FHR sensor. The circuit provides an output based on a uterine contraction signal from the EMG sensor (or Doppler ultrasound) correlated in time to a fetal movement, and/or fetal heart rate. The apparatus may include a thermometer to aid in automatically providing an indication of a pregnancy complication or ovulation status of the patient, based on the output.

Abstract: A microfluidic system for automatically depleting particles not of interest from a biological sample, comprising: a sampling module configured to receive the sample; and one or more microfluidic protein and nucleic acid depletion modules fluidically coupled to the sampling module and comprising binding agents configured to selectively bind to abundant plasma proteins or nucleic acids. A method for automatically depleting particles not of interest from a sample, comprising: receiving the sample; subjecting the sample to a force that separates at least a portion of the particles not of interest from the sample, thereby isolating at least a portion of the target component; passing the isolated target copmonent into a chamber; circulating the isolated target component in the chamber; and selectively capturing proteins or nucleic acids with binding agents within the chamber.

Abstract: Methods for quantitatively determining a binding kinetic parameter of a molecular binding interaction are provided. Aspects of embodiments of the methods include: producing a magnetic sensor device including a magnetic sensor in contact with an assay mixture including a magnetically labeled molecule to produce a detectable molecular binding interaction; obtaining a real-time signal from the magnetic sensor; and quantitatively determining a binding kinetics parameter of the molecular binding interaction from the real-time signal. Also provided are systems and kits configured for use in the methods.

Abstract: At least one walking member that may be used in conjunction with an in-line skate to enable the wearer of the in-line skate to walk while wearing the in-line skate.

Abstract: At least one walking member is detachably connectable to an in-line skate to enable the wearer of the in-line skate to connect the walking member to the in-line skate, thus enabling the wearer to walk while wearing the in-line skate. Two walking members can be provided on alternative sides of the in-line skate wheels to provide a more stable platform for the wearer of the in-line skate. Since the two walking members are removable, the walking members do not detract from the aerodynamic and functional performance of the in-line skate, and can be manufactured together with the skate or, alternatively, can be added to the skate after purchase.

Abstract: A device for disabling or otherwise allowing the wearer of an in-line skate to walk on the in-line skate without activating the wheels may include a clamping member to clamp the wheels. A switch may be activated which in turn activates or deactivates the clamping member. A walking member may also be provided, the walking member being coupled to the skate and moveable between first and second positions. In the first position the walking member may be secured such that the wearer may walk on the walking member. In the second position, the walking member is positioned such that it will not interfere when skating.

Abstract: At least one walking member is detachably connectable to an in-line skate to enable the wearer of the in-line skate to connect the walking member to the in-line skate, thus enabling the wearer to walk while wearing the in-line skate. Two walking members can be provided on alternative sides of the in-line skate wheels to provide a more stable platform for the wearer of the in-line skate. Since the two walking members are removable, the walking members do not detract from the aerodynamic and functional performance of the in-line skate, and can be manufactured together with the skate or, alternatively, can be added to the skate after purchase.

Abstract: A device for disabling or otherwise allowing the wearer of an in-line skate to walk on the in-line skate without activating the wheels may include a clamping member to clamp the wheels. A switch may be activated which in turn activates or deactivates the clamping member. A walking member may also be provided, the walking member being coupled to the skate and moveable between first and second positions. In the first position the walking member may be secured such that the wearer may walk on the walking member. In the second position, the walking member is positioned such that it will not interfere when skating.

Abstract: At least one walking member is detachably connectable to an in-line skate to enable the wearer of the in-line skate to connect the walking member to the in-line skate, thus enabling the wearer to walk while wearing the in-line skate. Two walking members can be provided on alternative sides of the in-line skate wheels to provide a more stable platform for the wearer of the in-line skate. Since the two walking members are removable, the walking members do not detract from the aerodynamic and functional performance of the in-line skate, and can be manufactured together with the skate or, alternatively, can be added to the skate after purchase.

Abstract: At least one walking member is detachably connectable to an in-line skate to enable the wearer of the in-line skate to connect the walking member to the in-line skate, thus enabling the wearer to walk while wearing the in-line skate. Two walking members can be provided on alternative sides of the in-line skate wheels to provide a more stable platform for the wearer of the in-line skate. Since the two walking members are removable, the walking members do not detract from the aerodynamic and functional performance of the in-line skate, and can be manufactured together with the skate or, alternatively, can be added to the skate after purchase.

Abstract: A device for disabling or otherwise allowing the wearer of an in-line skate to walk on the in-line skate without activating the wheels may include a clamping member to clamp the wheels. A switch may be activated which in turn activates or deactivates the clamping member. A walking member may also be provided, the walking member being coupled to the skate and moveable between first and second positions. In the first position the walking member may be secured such that the wearer may walk on the walking member. In the second position, the walking member is positioned such that it will not interfere when skating.

Abstract: At least one walking member is detachably connectable to an in-line skate to enable the wearer of the in-line skate to connect the walking member to the in-line skate, thus enabling the wearer to walk while wearing the in-line skate. Two walking members can be provided on alternative sides of the in-line skate wheels to provide a more stable platform for the wearer of the in-line skate. Since the two walking members are removable, the walking members do not detract from the aerodynamic and functional performance of the in-line skate, and can be manufactured together with the skate or, alternatively, can be added to the skate after purchase.

Abstract: At least one walking member is adaptively coupled to an in-line skate to enable the walking member to be extended and retracted to and from the skate, thereby enabling the in-line skate to be converted from a rolling skate to a walking shoe. Two walking members can be provided on alternative sides of the in-line skate wheels to provide a more stable platform for the wearer of the in-line skate. The walking members do not detract from the aerodynamic and functional performance of the in-line skate, and can be manufactured together with the skate or, alternatively, can be added to the skate after purchase.