Patents by Inventor Richard S. Graham

Richard S. Graham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Ophthalmic compositions comprising polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymers
    Patent number: 9579385
    Abstract: Compositions and methods related to ophthalmic use of polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymers and therapeutic uses are described herein.
    Type: Grant
    Filed: January 10, 2014
    Date of Patent: February 28, 2017
    Assignee: ALLERGAN, INC.
    Inventors: Anuradha V. Gore, Chetan P. Pujara, Richard S. Graham, Melissa Gulmezian, Kristin Prinn, Ramakrishnan Srikumar
  • Cyclosporin compositions
    Patent number: 9561178
    Abstract: Disclosed herein are therapeutic methods, compositions, and medicaments related to cyclosporine.
    Type: Grant
    Filed: July 20, 2007
    Date of Patent: February 7, 2017
    Assignee: Allergan, Inc.
    Inventors: Richard S. Graham, Walter L. Tien, Mayssa Attar, Rhett Schiffman, Aileen Morgan
  • KETOROLAC TROMETHAMINE COMPOSITIONS FOR TREATING OR PREVENTING OCULAR PAIN
    Publication number: 20160243078
    Abstract: The present invention provides an aqueous ophthalmic solution comprising an effective amount of ketorolac which comprises carboxymethyl cellulose in an aqueous solution which provides increased visual acuity in users and wherein said concentration of carboxymethyl cellulose is selected to provide an increased absorption of ketorolac in the eye of a patient which is at least 130% greater than the absorption of a comparative aqueous ketorolac ophthalmic solution having the same concentration of ketorolac.
    Type: Application
    Filed: October 16, 2015
    Publication date: August 25, 2016
    Inventors: Eldon Quinn Farnes, Mayassa Attar, Rhett M. Schiffman, Chin-Ming Chang, Richard S. Graham, Devin F. Welty
  • CRYSTALLINE FORM OF CYCLOSPORIN A, METHODS OF PREPARATION, AND METHODS FOR USE THEREOF
    Publication number: 20160083432
    Abstract: The present invention relates generally to crystalline forms of cyclosporin A and particularly to a newly identified form of cyclosporin A. The invention further relates to methods for its preparation and to methods for treating certain ocular disorders.
    Type: Application
    Filed: December 7, 2015
    Publication date: March 24, 2016
    Inventors: Anuradha V. Gore, Thomas K. Karami, Ke Wu, Richard S. Graham, Scott W. Smith
  • Crystalline form of cyclosporine A, methods of preparation, and methods for use thereof
    Patent number: 9206228
    Abstract: The present invention relates generally to crystalline forms of cyclosporine A and particularly to a newly identified form of cyclosporine A. The invention further relates to methods for its preparation and to methods for treating certain ocular disorders.
    Type: Grant
    Filed: July 2, 2014
    Date of Patent: December 8, 2015
    Assignee: Allergan, Inc.
    Inventors: Anuradha V. Gore, Thomas K. Karami, Ke Wu, Richard S. Graham, Scott W. Smith
  • Ketorolac tromethamine compositions for treating or preventing ocular pain
    Patent number: 9192571
    Abstract: The present invention provides an aqueous ophthalmic solution with an effective amount of ketorolac and carboxymethyl cellulose in an aqueous solution which provides increased visual acuity and wherein the concentration of carboxymethyl cellulose is selected to provide an increased absorption of ketorolac in the eye of a patient that is at least 130% greater than the absorption of a comparative aqueous ketorolac ophthalmic solution having the same concentration of ketorolac.
    Type: Grant
    Filed: September 1, 2009
    Date of Patent: November 24, 2015
    Assignee: Allergan, Inc.
    Inventors: Eldon Q. Farnes, Mayssa Attar, Rhett M. Schiffman, Chin-Ming Chang, Richard S. Graham, Devin F. Welty
  • Pharmaceutical compositions comprising cyclosporins
    Patent number: 8906861
    Abstract: A composition is described herein comprising cyclosporin A, polysorbate 80, a polyoxyethylene stearate, and an oil; wherein the composition is an emulsion which is ophthalmically acceptable. Methods of treating diseases or conditions using said compositions, and medicaments related thereto, are also disclosed herein.
    Type: Grant
    Filed: January 28, 2009
    Date of Patent: December 9, 2014
    Assignee: Allergan, Inc.
    Inventors: Walter L. Tien, Richard S. Graham, James N. Chang
  • CRYSTALLINE FORM OF CYCLOSPORINE A, METHODS OF PREPARATION, AND METHODS FOR USE THEREOF
    Publication number: 20140315827
    Abstract: The present invention relates generally to crystalline forms of cyclosporine A and particularly to a newly identified form of cyclosporine A. The invention further relates to methods for its preparation and to methods for treating certain ocular disorders.
    Type: Application
    Filed: July 2, 2014
    Publication date: October 23, 2014
    Inventors: Anuradha V. Gore, Thomas K. Karami, Ke Wu, Richard S. Graham, Scott W. Smith
  • Compositions containing alpha-2-adrenergic agonist components
    Patent number: 8858961
    Abstract: Compositions useful for improving effectiveness of alpha-2-adrenergic agonist components include carrier components, alpha-2-adrenergic agonist components, solubility enhancing components which aid in solubilizing the alpha-2-adrenergic agonist components. In one embodiment, the alpha-2-adrenergic agonist components include alpha-2-adrenergic agonists. In another embodiment, the solubility enhancing components include carboxymethylcellulose.
    Type: Grant
    Filed: June 11, 2009
    Date of Patent: October 14, 2014
    Assignee: Allergan, Inc.
    Inventors: Richard S. Graham, Peter G. Bakhit, Orest Olejnik
  • MACROGOL 15 HYDROXYSTEARATE FORMULATIONS
    Publication number: 20140287988
    Abstract: Provided herein are compositions, which include an active pharmaceutical ingredient and macrogol 15 hydroxystearate, and methods for using the same for treating diseases or disorder.
    Type: Application
    Filed: December 9, 2013
    Publication date: September 25, 2014
    Applicant: ALLERGAN, INC.
    Inventors: ANURADHA V. GORE, KEVIN S. WARNER, CHETAN P. PUJARA, RICHARD S. GRAHAM, AJAY P. PARASHAR, MU-LAN LEE, ROBERT S. JORDAN, SUKHON LIKITLERSUANG
  • FIXED DOSE COMBINATION OF BIMATOPROST AND BRIMONIDINE
    Publication number: 20140249153
    Abstract: The present invention is directed to compositions comprising combinations of brimonidine and bimatoprost useful for lowering intraocular pressure in a patient and for the treatment of glaucoma.
    Type: Application
    Filed: July 20, 2012
    Publication date: September 4, 2014
    Applicant: Allergan, Inc.
    Inventors: Richard S. Graham, Chetan P. Pujara, Sesha Neervannan, Anuradha V. Gore, Kevin S. Warner
  • Crystalline form of cyclosporine A, methods of preparation, and methods for use thereof
    Patent number: 8772245
    Abstract: The present invention relates generally to crystalline forms of cyclosporine A and particularly to a newly identified form of cyclosporine A. The invention further relates to methods for its preparation and to methods for treating certain ocular disorders.
    Type: Grant
    Filed: May 25, 2012
    Date of Patent: July 8, 2014
    Assignee: Allergan, Inc.
    Inventors: Anuradha V. Gore, Kiomars Karami, Ke Wu, Richard S. Graham, Scott W. Smith
  • PRESERVED TOPICAL FORMULATIONS WITH IMPROVED ANTIMICROBIAL ACTIVITY
    Publication number: 20140127327
    Abstract: A preservative consisting of a stabilized oxychloro complex and a polyol having from 3 to 6 carbons is disclosed herein. A composition comprising a stabilized chlorine dioxide. and a polyol having from 3 to 6 carbons is also disclosed herein.
    Type: Application
    Filed: November 6, 2013
    Publication date: May 8, 2014
    Applicant: Allergan, Inc.
    Inventors: Richard S. Graham, Walter L. Tien
  • OPHTHALMIC COMPOSITIONS COMPRISING POLYVINYL CAPROLACTAM-POLYVINYL ACETATE-POLYETHYLENE GLYCOL GRAFT COPOLYMERS
    Publication number: 20140128329
    Abstract: Compositions and methods related to ophthalmic use of polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymers and therapeutic uses are described herein.
    Type: Application
    Filed: January 10, 2014
    Publication date: May 8, 2014
    Applicant: Allergan, Inc.
    Inventors: Anuradha V. Gore, Chetan P. Pujara, Richard S. Graham, Melissa Gulmezian, Kristin Prinn, Ramakrishnan Srikumar
  • KETOROLAC COMPOSITIONS FOR CORNEAL WOUND HEALING
    Publication number: 20130245088
    Abstract: The present invention is directed to an aqueous ophthalmic solution comprising an effective amount of ketorolac which comprises carboxymethyl cellulose which promotes epithelial wound healing in a patients cornea.
    Type: Application
    Filed: April 6, 2011
    Publication date: September 19, 2013
    Applicant: ALLERGAN, INC.
    Inventors: David A. Hollander, Linda Villanueva, Eldon Quinn Farnes, Mayssa Attar, Rhett M. Schiffman, Chin-Ming Chang, Richard S. Graham, Devin F. Welty
  • KETOROLAC TROMETHAMINE COMPOSITIONS FOR TREATING OR PREVENTING OCULAR PAIN
    Publication number: 20130030032
    Abstract: The present invention provides an aqueous ophthalmic solution comprising an effective amount of ketorolac which comprises carboxymethyl cellulose in an aqueous solution which provides increased visual acuity in users and wherein said concentration of carboxymethyl cellulose is selected to provide an increased absorption of ketorolac in the eye of a patient which is at least 130% greater than the absorption of a comparative aqueous ketorolac ophthalmic solution having the same concentration of ketorolac.
    Type: Application
    Filed: August 31, 2010
    Publication date: January 31, 2013
    Inventors: Eldon Q. Farnes, Mayssa Attar, Rhett M. Schiffman, Chin-Ming Chang, Richard S. Graham, Devin F. Welty
  • FIXED DOSE COMBINATION OF BIMATOPROST AND BRIMONIDINE
    Publication number: 20130023536
    Abstract: The present invention is directed to compositions comprising combinations of brimonidine and bimatoprost useful for lowering intraocular pressure in a patient and for the treatment of glaucoma
    Type: Application
    Filed: July 20, 2012
    Publication date: January 24, 2013
    Inventors: Richard S. Graham, Chetan P. Pujara, Sesha Neervannan, Anuradha V. Gore, Kevin S. Warner
  • CRYSTALLINE FORM OF CYCLOSPORINE A, METHODS OF PREPARATION, AND METHODS FOR USE THEREOF
    Publication number: 20130023482
    Abstract: The present invention relates generally to crystalline forms of cyclosporine A and particularly to a newly identified form of cyclosporine A. The invention further relates to methods for its preparation and to methods for treating certain ocular disorders.
    Type: Application
    Filed: May 25, 2012
    Publication date: January 24, 2013
    Inventors: Anuradha V. Gore, Kiomars Karami, Ke Wu, Richard S. Graham, Scott W. Smith
  • MACROGOL 15 HYDROXYSTEARATE FORMULATIONS
    Publication number: 20130005665
    Abstract: Provided herein are compositions, which include an active pharmaceutical ingredient and macrogol 15 hydroxystearate, and methods for using the same for treating diseases or disorder.
    Type: Application
    Filed: June 29, 2012
    Publication date: January 3, 2013
    Inventors: Anuradha V. Gore, Kevin S. Warner, Chetan P. Pujara, Richard S. Graham, Ajay Parashar, Mu-Lan Lee, Robert S. Jordan, Sukhon Likitlersuang
  • KETOROLAC TROMETHAMINE COMPOSITIONS FOR TREATING OR PREVENTING OCULAR PAIN
    Publication number: 20120196913
    Abstract: The present invention provides an aqueous ophthalmic solution comprising an effective amount of ketorolac which comprises carboxymethyl cellulose in an aqueous solution wherein said concentration of carboxymethyl cellulose is selected to provide an increased absorption of ketorolac in the eye of a patient that is at least 130% greater than the absorption of a comparative aqueous ketorolac ophthalmic solution having the same concentration of ketorolac.
    Type: Application
    Filed: April 13, 2012
    Publication date: August 2, 2012
    Applicant: ALLERGAN, INC.
    Inventors: Eldon Q. Farnes, Mayssa Attar, Rhett M. Schiffman, Chin-Ming Chang, Richard S. Graham, Devin F. Welty