Abstract: The present invention provides a septal defect closure device (10) having a first occluding disk (30) having a first flexible membrane (32) attached to a first frame (34) and a second occluding disk (20) having a second flexible membrane (22) attached to a separate second frame (24). The first frame has at least two outwardly extending loops joined to one another by flexible joints. These loops are attached to the first membrane to define taut fabric petals when the first disk is in a deployed configuration. A central portion of the first membrane is joined to the central portion of the second membrane via a joining segment, which may comprise a conjoint disk. The flexible joints of the first frame are received within the joining segment. This septal defect closure device provides enhanced retrievability.

Abstract: The invention provides a device for filtering emboli from blood flowing through a lumen defined by the walls of a vessel in a patient's body comprising a filter element. The filter is expandable from a collapsed configuration when the filter element is restrained to an expanded configuration when the filter element is unrestrained, and the filter element comprises a self-expanding material having pores. When the filter element is in the expanded configuration, the average pore size is from 30 to 300 microns and the standard deviation of the pore size is less than 20 percent of the average pore size.

Abstract: A method and system of performing an intravascular procedure at a treatment site in a vessel of a patient. A device creates a seal to prevent the flow of blood during the treatment of vascular disease. A seal may be formed between the distal inside diameter of a sheath or catheter such as a guide catheter as well as within a vessel, such as an artery or vein. An elongated device having a distal portion extending from the catheter and having a fluid impermeable membrane disposed about at least the distal end of the device is used to seal the vessel. The system includes a device to occlude blood flow and a distal protection device to filter or remove embolic debris.

Abstract: The invention provides a device for filtering emboli from blood flowing through a lumen defined by the walls of a vessel in a patient's body comprising a filter element. The filter element is expandable from a collapsed configuration when the filter element is restrained to an expanded configuration when the filter element is unrestrained. When the filter element is in the expanded configuration, the average pore size is from 30 to 300 microns and the standard deviation of the pore size is less than 20 percent of the average pore size. The filter element has two or more filtering layers, each filtering layer having pores, each filtering layer being adjacent to at least one other filtering layer, and at least one of the filtering layers being made of a self-expanding material.

Abstract: An embolic protection device or system for use in a lumen of a vessel in a patient's vascular system. The device filters debris and blood clots in a body lumen and/or prevents them from moving distally from a treatment site in a vessel and causing emboli. The device may include a filter placed distally of the treatment site. The device may include an occlusive element placed either distally or proximally of the treatment site.

Abstract: A device, method, and system of deploying an embolic protection device at a location distal to a treatment site in a vessel of a patient. A delivery catheter is encircled by a sealing member which is expandable from a delivery configuration to a deployed configuration. The device creates a seal to prevent the flow of blood during the treatment of vascular disease. A distal protection element is delivered by the delivery catheter and deployed to filter or remove embolic debris.

Abstract: The present invention provides a septal defect closure device (10) having a first occluding disk (30) having a first flexible membrane (32) attached to a first frame (34) and a second occluding disk (20) having a second flexible membrane (22) attached to a separate second frame (24). The first frame has at least two outwardly extending loops joined to one another by flexible joints. These loops are attached to the first membrane to define taut fabric petals when the first disk is in a deployed configuration. A central portion of the first membrane is joined to the central portion of the second membrane via a joining segment, which may comprise a conjoint disk. The flexible joints of the first frame are received within the joining segment. This septal defect closure device provides enhanced retrievability.

Abstract: Devices and methods for delivering stents to target vessel regions, including stent delivery through microcatheters to narrow cerebral arteries. One stent delivery device includes a stent having the distal region everted over the distal end of a delivery tube, having the everted stent distal end captured by a distal element of a elongate release member disposed through the delivery tube. The delivery tube can have a distal taper to a small profile distal end. The everted stent distal region can be captured between the release member distal element and the surrounding delivery tube distal region walls. The captured and everted stent can be distally advanced to a target site, followed by manipulating the release member to free the captured stent. Some devices utilize distal advancement of the release member while other devices use proximal retraction of the release member to free the captured stent distal end.

Abstract: A collapsible medical device for use, e.g., as a vascular filter. The device includes a mandrel having a distal end and a stop spaced proximally of the distal end. A proximal length of the mandrel extends proximally of the stop and a distal length of the mandrel extends distally of the stop. A functional element (e.g., a vascular filter) has a radially expandable body and includes a proximal slider and a distal slider. The proximal and distal sliders are slidable along the mandrel independently of one another such that the distance between the proximal slider and distal slider can be varied to effect different configurations of the functional element. In one method of using such a device, the functional element is urged distally to a treatment site by urging the mandrel distally.

Abstract: A combination dilatation and drug delivery device includes a flexible catheter, a drug delivery sheath mounted to a distal end region of the catheter and a dilatation balloon also mounted to the catheter and contained within a compartment formed by the sheath. The sheath is radially expandable by supplying a liquid therapeutic agent to the compartment under a moderate pressure. The dilatation balloon is expandable by providing a dilatation fluid to the balloon under a much higher pressure. The sheath can be formed of a highly elastic material or can be made quite thin, and in either case is mounted independently of the dilatation balloon. Thus when radially expanded, the sheath is moved into a conforming contact with surrounding vascular tissue. The conforming contact protects tissue and the therapeutic agent from exposure to blood, and more effectively confines the therapeutic agent to the intended treatment area.

Abstract: The invention provides a catheter for use in combination with an elongate support member. The catheter comprises an elongate body having a proximal portion, a proximal end, a distal portion, a distal end, and a main shaft; an element disposed on the distal portion of the elongate body, the element being an interventional element or a delivery element for delivery of an interventional element; at least one lumen dimensioned to receive the elongate support member; and a tube wall disposed about the lumen. The tube wall has at least one removable segment disposed on the proximal portion of the elongate body and at least one non-removable segment disposed on the distal portion of the elongate body, the removable segment is tubular or generally tubular having a partial circular circumferential cross section, and the transverse cross-sectional area of the removable segment does not comprise the entire transverse cross-sectional area of the catheter.

Abstract: An intravascular medical device including an elongated member configured to be advanced along a vascular path of a patient, the elongated member having opposite first and second ends, the first end and second ends both being adapted for intravascular insertion, and the first end having a different structure than the second end. The elongated member has sufficient flexibility to be advanced through a human vasculature. Preferably, the first and second ends are adapted to have different operating characteristics. Depending on the operating characteristics needed for a particular procedure, a physician can insert either the first end portion or the second end portion of the elongated member into the patient's vasculature.

Abstract: A catheter provided with a collapsible inner lumen within a main body. The catheter can deploy a distal protection device using a guidewire which is threaded through the inner lumen, the inner lumen collapsing upon retrieval of the device into the catheter main body.

Abstract: A biocompatible laminate fabric includes a porous first membrane layer, a porous second membrane layer, and an open mesh bonding layer between the first and second membrane layers. The bonding layer holds the first and second membrane layers together by extending into one or more pores of each membrane layer.

Abstract: A catheter provided with a collapsible inner lumen within a main body. The catheter can deploy a distal protection device using a guidewire which is threaded through the inner lumen, the inner lumen collapsing upon retrieval of the device into the catheter main body.

Abstract: A distal protection device for use in a body lumen. The device includes a functional element which may be a filter or an occlusive element. The device includes means for controlling the movement and placement of the functional element along a guidewire. Motion of the guidewire can be independent of the motion of the functional element.

Abstract: The invention provides a device for filtering emboli from blood flowing through a lumen defined by the walls of a vessel in a patient's body comprising a filter element. The filter is expandable from a collapsed configuration when the filter element is restrained to an expanded configuration when the filter element is unrestrained, and the filter element comprises a self-expanding material having pores. When the filter element is in the expanded configuration, the average pore size is from 30 to 300 microns and the standard deviation of the pore size is less than 20 percent of the average pore size.

Abstract: The invention provides a device for filtering emboli from blood flowing through a lumen defined by the walls of a vessel in a patient's body, comprising a filter element and a self-expanding radial element associated with the filter element. The filter element is expandable from a collapsed configuration when the filter element is restrained to an expanded configuration when the filter element is unrestrained. The filter element comprises a self-expanding material having pores. The filter element has proximal and distal portions and a central portion, and has a shape in the expanded configuration which defines a cavity having a proximal facing opening. The self-expanding radial element is distal of the filter element, and the self-expanding radial element is adapted to maintain the filter element centered in the lumen.

Abstract: The invention provides a device for filtering emboli from blood flowing through a lumen defined by the walls of a vessel in a patient's body comprising a filter element. The filter element is expandable from a collapsed configuration when the filter element is restrained to an expanded configuration when the filter element is unrestrained. When the filter element is in the expanded configuration, the average pore size is from 30 to 300 microns and the standard deviation of the pore size is less than 20 percent of the average pore size. The filter element has two or more filtering layers, each filtering layer having pores, each filtering layer being adjacent to at least one other filtering layer, and at least one of the filtering layers being made of a self-expanding material.

Abstract: The present invention provides a method of deploying a medical filter within a channel in a patient's body and filter systems which can be used in such a method. Such a filter may include a radially expandable body 52 having an opening 56 in a proximal length thereof. In one method, the filter is urged along a length of the channel with the filter body in a radially reduced configuration. This body is expanded to substantially fill the lumen of the vessel and orient the opening in the body proximally. Body fluid is permitted to enter the filter body through the proximally oriented opening and pass distally through the distal length of the body so that the distal length of the body filters from the body fluid particulate material entrained therein. The proximal length of the body can be drawn into the retrieval catheter, thereby effectively closing the proximally oriented opening within the catheter to retain the particulate material within the enclosure.