Abstract: A method of preparing a stable chitosan hemostatic implant including preparing a lyophilizable solution of chitosan polymers and freezing the solution to obtain a frozen chitosan composition. The method further includes placing the frozen chitosan composition under vacuum so as to substantially dry the chitosan composition and curing the dried chitosan composition by first exposing it to a relative humidity and then curing the dried chitosan composition under heat so as to crosslink the chitosan polymers.

Abstract: Implantable hemostatic products with improved stability are prepared from crosslinked chitosan hemostatic compositions. The crosslinked chitosan hemostatic compositions have improved stability and can be prepared into a variety of implantable medical devices in various shapes and sizes so as to be usable for inhibiting blood flow and ooze from substantially any type of internal bleeding site. For example, the chitosan compositions can be prepared into hemostatic gauze pads, bandages, dressings, wound plugs, incision plugs, arteriotomy plugs, tissue fillers, sealers, sheets, rolls, combinations thereof, and the like.

Abstract: Hemostatic products with improved stability are prepared from crosslinked chitosan hemostatic compositions. The crosslinked chitosan hemostatic compositions have improved stability and can be prepared into a variety of medical devices in various shapes and sizes so as to be usable for inhibiting blood flow and ooze from substantially any type of bleeding site. For example, the chitosan compositions can be prepared into hemostatic gauze pads, bandages, wrappings, wound dressings, wound coverings, wound dressings, incision dressings, sealers, sheets, rolls, combinations thereof, and the like.