Patents by Inventor Richard Shimkets
Richard Shimkets has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11918649Abstract: Provided herein are PD-L1 binding molecules comprising or conjugated to a toxin, e.g. a Shiga toxin A Subunit derived polypeptide. In some embodiments, the PD-L1 binding molecules are cytotoxic. In some embodiments, the PD-L1 binding molecules are capable of delivering a CD8+ T-cell epitope to an MHC class molecule inside a PD-L1 positive cell. The PD-L1 binding molecules described herein have uses for selectively killing specific cells (e.g., PD-L1 positive tumor cells and/or immune cells); for selectively delivering cargos to specific cells (e.g., PD-L1 positive tumor cells or immune cells), and as therapeutic and/or diagnostic molecules for treating and diagnosing a variety of conditions, including cancers and tumors involving PD-L1 expressing cells (e.g., PD-L1 positive tumor cells or immune cells).Type: GrantFiled: September 18, 2020Date of Patent: March 5, 2024Assignee: Molecular Templates, Inc.Inventors: Eric Poma, Hilario Ramos, Erin Willert, Richard Shimkets, Crystal Jackson, Thomas Vincent
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Publication number: 20230313318Abstract: Microsatellite markers, and method of use thereof, for differentiating isolates of D. immitis heartworms and/or other parasites. A method of testing new products for drug-susceptible and/or resistant isolates of heartworms using the microsatellite markers disclosed herein.Type: ApplicationFiled: January 30, 2023Publication date: October 5, 2023Applicant: TRS Labs IncInventors: Crystal FRICKS, Ray Kaplan, John W McCall, Richard Shimkets
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Patent number: 11136395Abstract: Provided herein are PD-L1 binding molecules comprising or conjugated to a toxin, e.g. a Shiga toxin A Subunit derived polypeptide. In some embodiments, the PD-L1 binding molecules are cytotoxic. In some embodiments, the PD-L1 binding molecules are capable of delivering a CD8+ T-cell epitope to an MHC class molecule inside a PD-L1 positive cell. The PD-L1 binding molecules described herein have uses for selectively killing specific cells (e.g., PD-L1 positive tumor cells and/or immune cells); for selectively delivering cargos to specific cells (e.g., PD-L1 positive tumor cells or immune cells), and as therapeutic and/or diagnostic molecules for treating and diagnosing a variety of conditions, including cancers and tumors involving PD-L1 expressing cells (e.g., PD-L1 positive tumor cells or immune cells).Type: GrantFiled: September 21, 2020Date of Patent: October 5, 2021Assignee: Molecular Templates, Inc.Inventors: Eric Poma, Hilario Ramos, Erin Willert, Richard Shimkets, Crystal Jackson, Thomas Vincent
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Publication number: 20210079097Abstract: Provided herein are PD-L1 binding molecules comprising or conjugated to a toxin, e.g. a Shiga toxin A Subunit derived polypeptide. In some embodiments, the PD-L1 binding molecules are cytotoxic. In some embodiments, the PD-L1 binding molecules are capable of delivering a CD8+ T-cell epitope to an MHC class molecule inside a PD-L1 positive cell. The PD-L1 binding molecules described herein have uses for selectively killing specific cells (e.g., PD-L1 positive tumor cells and/or immune cells); for selectively delivering cargos to specific cells (e.g., PD-L1 positive tumor cells or immune cells), and as therapeutic and/or diagnostic molecules for treating and diagnosing a variety of conditions, including cancers and tumors involving PD-L1 expressing cells (e.g., PD-L1 positive tumor cells or immune cells).Type: ApplicationFiled: September 18, 2020Publication date: March 18, 2021Inventors: Eric Poma, Hilario Ramos, Erin Willert, Richard Shimkets, Crystal Jackson, Thomas Vincent
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Publication number: 20210079098Abstract: Provided herein are PD-L1 binding molecules comprising or conjugated to a toxin, e.g. a Shiga toxin A Subunit derived polypeptide. In some embodiments, the PD-L1 binding molecules are cytotoxic. In some embodiments, the PD-L1 binding molecules are capable of delivering a CD8+ T-cell epitope to an MEW class molecule inside a PD-L1 positive cell. The PD-L1 binding molecules described herein have uses for selectively killing specific cells (e.g., PD-L1 positive tumor cells and/or immune cells); for selectively delivering cargos to specific cells (e.g., PD-L1 positive tumor cells or immune cells), and as therapeutic and/or diagnostic molecules for treating and diagnosing a variety of conditions, including cancers and tumors involving PD-L1 expressing cells (e.g., PD-L1 positive tumor cells or immune cells).Type: ApplicationFiled: September 21, 2020Publication date: March 18, 2021Inventors: Eric Poma, Hilario Ramos, Erin Willert, Richard Shimkets, Crystal Jackson, Thomas Vincent
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Publication number: 20080171046Abstract: Disclosed herein are novel human nucleic acid sequences which encode polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.Type: ApplicationFiled: May 12, 2004Publication date: July 17, 2008Inventors: Corine Vermet, Elma Fernandes, Richard Shimkets, John Herrmann, Kumud Majumder, John MacDougall, Vishnu Mishra, Peter S. Mezes, Luca Rastelli
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Publication number: 20070166756Abstract: The invention provides polypeptides, designated herein as SECP polypeptides, as well as polynucleotides encoding SECP polypeptides, and antibodies that immunospecifically-bind to SECP polypeptide or polynucleotide, or derivatives, variants, mutants, or fragments thereof. The invention additionally provides methods in which the SECP polypeptide, polynucleotide, and antibody are used in the detection, prevention, and treatment of a broad range of pathological states.Type: ApplicationFiled: March 15, 2007Publication date: July 19, 2007Inventors: Richard Shimkets, Elma Fernandes
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Publication number: 20070042421Abstract: Disclosed are methods for identifying nucleic acids in a sample of nucleic acids in which nucleic acids are initially present in unequal amounts. The methods include partitioning the starting population of nucleic acids to form one or more subpopulations, and then identifying nucleic acids that are present in different amounts in the partitioned nucleic acid sample as compared to the starting population.Type: ApplicationFiled: November 1, 2006Publication date: February 22, 2007Inventors: Jonathan Rothberg, Michael McKenna, Paul Predki, Andreas Windemuth, Richard Shimkets
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Patent number: 7141549Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.Type: GrantFiled: February 8, 2005Date of Patent: November 28, 2006Inventors: Peter Mezes, Luca Rastelli, John Herrmann, John MacDougall, Haihong Zhong, Stacie Casman, Ferenc Boldog, Richard Shimkets, Linda Gorman, Andrew Eisen, Steven Spaderna, Corine Vernet, Constance Berghs, Kimberly Spytek, Vincent DiPippo, Bryan Zerhusen, John Peyman, Karen Ellerman, David Stone, William Grosse, John Alsobrook, II, Denise Lepley, Daniel Rieger, Catherine Burgess, Shlomit Edinger, Edward Voss, Charles Miller
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Publication number: 20060257882Abstract: This application is drawn to novel nucleic acid sequences encoding mammalian polypeptides that have sequence similarity to human breast tumor-associated protein 47. The nucleic acid sequence is 1987 nucleotides long and contains an open reading frame from nucleotides 991 to 1447. The novel, encoded polypeptides comprise 152 amino acid residues.Type: ApplicationFiled: April 21, 2005Publication date: November 16, 2006Inventors: Richard Shimkets, Elma Fernandes, John Herrman, Corine Vernet
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Publication number: 20060141565Abstract: The present invention generally relates to nucleic acids, proteins, and antibodies. The invention relates more particularly to nucleic acid molecules, proteins, and antibodies of Fibroblast Growth Factor-20 (FGF-22), or its fragments, derivatives, variants, homologs, analogs, or a combination thereof.Type: ApplicationFiled: December 6, 2004Publication date: June 29, 2006Inventors: Meera Patturajan, Isabelle Millet, Sampath Kumar, Charles Miller, Peter Mezes, Denise Lepley, Catherine Burgess, Richard Shimkets
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Publication number: 20060111561Abstract: Disclosed are novel proteins and nucleic acids encoding same. Also disclosed are vectors, host cells, antibodies and recombinant methods for producing the proteins and polynucleotides, as well as methods for using same.Type: ApplicationFiled: August 31, 2005Publication date: May 25, 2006Inventors: Valerie Gerlach, Elma Fernandes, Richard Shimkets, Meera Patturajan, Vladimir Gusev, Stacie Navara, Velizar Tchernev, David Anderson, Xiaojia Guo, Luca Rastelli, Mei Zhong, Muralidhara Padigaru
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Publication number: 20060094647Abstract: The present invention is based upon methods of treating inflammatory conditions in the intestinal tract of mammals using growth factor related polypeptides. Methods of using fibroblast growth factor-CX (FGF-CX) polynucleotide sequences and the FGF-CX polypeptides encoded by such nucleic acid sequences, or variants, fragments and homologs thereof, are claimed in the invention. Similarly, methods of using FCTRX polynucleotide sequences and the FCTRX polypeptides encoded by such nucleic acid sequences, or variants, fragments and homologs thereof, alone or in combination, are also claimed in the invention. FCTRX collectively refers to any of six variant FCTRX sequences, variously designated FCTR1, FCTR2, FCTR3, FCTR4, FCTR5 and FCTR6.Type: ApplicationFiled: November 6, 2001Publication date: May 4, 2006Inventors: Michael Jeffers, Richard Shimkets, Sudhirdas Prayaga, Ferenc Boldog, Meijia Yang, Catherine Burgess, Elma Fernandes, Beth Rittman, Juliette Shimkets, William LaRochelle, Henri Lichenstein
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Publication number: 20060084054Abstract: The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.Type: ApplicationFiled: June 4, 2003Publication date: April 20, 2006Inventors: John Alsobrook, David Anderson, Jason Baumgartner, Constance Berghs, Ferenc Boldog, Catherine Burgess, Stacie Casman, Elina Catterton, Mohanraj Dhanabal, Shlomit Edinger, Karen Ellerman, Seth Ettenberg, Esha Gangolli, Valerie Gerlach, Linda Gorman, William Grosse, Erik Gunther, Xiaojia Guo, Vladimir Gusev, John Herrmann, Weizhen Ji, Ramesh Kekuda, Nikolai Khramtsov, William LaRochelle, Li Li, Hongping Liang, Kenneth Low, John MacDougall, Timothy Maclachlan, Uriel Malyankar, Kelly McQueeney, Amanda Mezick, Charles Miller, Isabelle Millet, Muralidhara Padigaru, Meera Patturajan, John Peyman, Xiaozhong Qian, Luca Rastelli, Daniel Rieger, Mark Rothenberg, Suresh Shenoy, Richard Shimkets, Glennda Smithson, Kimberly Spytek, David Stone, Sujatha Sukumaran, Edward Szekeres, Corine Vernet, Edward Voss, Adam Wolenc, Mei Zhong, Haihong Zhong
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Publication number: 20060063200Abstract: Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.Type: ApplicationFiled: February 2, 2005Publication date: March 23, 2006Applicant: CuraGen CorporationInventors: David Anderson, Jason Baumgartner, Ferenc Boldog, Stacie Casman, Shlomit Edinger, Esha Gangolli, Valerie Gerlach, Linda Gorman, Xiaojia Guo, Tord Hjalt, Ramesh Kekuda, Li Li, John MacDougall, Uriel Malyankar, Isabelle Millet, Muralidhara Padigaru, Meera Patturajan, Carol Pena, Luca Rastelli, Richard Shimkets, David Stone, Kimberly Spytek, Corine Vernet, Edward Voss, Bryan Zerhusen
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Publication number: 20060057664Abstract: The invention provides polypeptides, designated herein as SECP polypeptides, as well as polynucleotides encoding SECP polypeptides, and antibodies that immunospecifically-bind to SECP polypeptide or polynucleotide, or derivatives, variants, mutants, or fragments thereof. The invention additionally provides methods in which the SECP polypeptide, polynucleotide, and antibody are used in the detection, prevention, and treatment of a broad range of pathological states.Type: ApplicationFiled: June 2, 2003Publication date: March 16, 2006Applicant: CuraGen CorporationInventors: Richard Shimkets, Elma Fernandes
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Publication number: 20060014153Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.Type: ApplicationFiled: June 25, 2004Publication date: January 19, 2006Inventors: Valerie Gerlach, John MacDougall, Glennda Smithson, Isabelle Millet, David Stone, Erik Gunther, Karen Ellerman, William Grosse, John Alsobrook, Denise Lepley, Catherine Burgess, Muralidhara Padigaru, Ramesha Kekuda, Kimberly Spytek, Martin Leach, Richard Shimkets
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Publication number: 20060013813Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.Type: ApplicationFiled: February 8, 2005Publication date: January 19, 2006Inventors: Peter Mezes, Luca Rastelli, John Herrmann, John MacDougall, Haihong Zhong, Stacie Casman, Frenc Boldog, Richard Shimkets, Linda Gorman, Andrew Eisen, Steven Spaderna, Corine Vernet, Constance Berghs, Kimberly Spytek, Vincent DiPippo, Bryan Zerhusen, John Peyman, Karen Ellerman, David Stone, William Grosse, John Alsobrook, Denise Lepley, Daniel Rieger, Catherine Burgess, Sholmit Edinger, Edward Voss, Charles Miller
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Publication number: 20060003323Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.Type: ApplicationFiled: June 3, 2003Publication date: January 5, 2006Inventors: John Alsobrook, Enrique Alvarez, David Anderson, Ferenc Boldog, Stacie Casman, Elina Catterton, Andrei Chapoval, Julie Crabtree-Bokor, Shlomit Edinger, Karen Ellerman, Seth Ettenberg, Esha Gangolli, Valerie Gerlach, Linda Gorman, Erik Gunther, Xiaojia (Sasha) Guo, Vladimir Gusev, John Herrmann, Weizhen Ji, Ramesh Kekuda, Li Li, Xiaohong Liu, John MacDougall, Timothy Machlachlan, Uriel Malyankar, Amanda Mezick, Isabelle Millet, Vishnu Mishra, Muralidhara Padigaru, Meera Patturajan, Carol Pena, John Peyman, Debasish Raha, Luca Rastelli, Daniel Rieger, Mark Rothenberg, Paul Sciore, Suresh Shenoy, Richard Shimkets, Glennda Smithson, Kimberly Spytek, David Stone, Corine Vernet, Edward Voss, Mei Zhong, Hiahong Zhong
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Publication number: 20050287564Abstract: Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.Type: ApplicationFiled: May 10, 2005Publication date: December 29, 2005Inventors: Linda Gorman, Richard Shimkets, Carol Pena, Valerie Gerlach, Kumud Majumder, Sudhirdas Prayaga, Catherine Burgess
