Abstract: An apparatus applies traction to a big toe of a patient's foot at a desired adduction angle and a desired dorsiflexion angle, for use in treating a bunion. The apparatus includes: a shoe portion (e.g., a sole, and strap(s)); a toe attachment apparatus (e.g., a Chinese finger trap) having a cable extending therefrom; and an apparatus (e.g., a ratchet, an actuator, and the like) configured to apply tension to the cable with respect to the sole. A support bracket is configured to pivot with respect to the shoe portion to adjust the adduction angle of the cable with respect to an axial direction of the sole, and is further configured to extend upwardly to at an elevated position with respect to the sole. An adjustment member is mounted to slide relative to the support bracket, to adjust the dorsiflexion angle provided by the cable independent of the adduction angle.

Abstract: In device for placing a toe of a patient's foot in traction may broadly include a shoe portion (e.g., a sole, counter, and strap(s)); a toe attachment apparatus (e.g., a Chinese finger trap) having a cable extending therefrom; a pulley, with the cable wrapped about the pulley; and an apparatus (e.g., a ratchet, an actuator, and the like) configured to apply tension to the cable to create traction in the toe. A second actuator may adjust lateral positioning of the pulley relative to the shoe portion to set a desired angle of adduction for the traction provided to the toe by the cable. A meter may be coupled to the cable to indicate an amount of tension provided thereto. Another actuator may adjust elevational positioning of the pulley relative to the shoe portion to set a desired angle of dorsiflexion for the traction provided to the toe by the cable.

Abstract: In device for placing a toe of a patient's foot in traction may broadly include a shoe portion (e.g., a sole, counter, and strap(s)); a toe attachment apparatus (e.g., a Chinese finger trap) having a cable extending therefrom; a pulley, with the cable wrapped about the pulley; and an apparatus (e.g., a ratchet, an actuator, and the like) configured to apply tension to the cable to create traction in the toe. A second actuator may adjust lateral positioning of the pulley relative to the shoe portion to set a desired angle of adduction for the traction provided to the toe by the cable. A meter may be coupled to the cable to indicate an amount of tension provided thereto. Another actuator may adjust elevational positioning of the pulley relative to the shoe portion to set a desired angle of dorsiflexion for the traction provided to the toe by the cable.

Abstract: In device for placing a toe of a patient's foot in traction may broadly include a shoe portion (e.g., a sole, counter, and strap(s)); a toe attachment apparatus (e.g., a Chinese finger trap) having a cable extending therefrom; a pulley, with the cable wrapped about the pulley; and an apparatus (e.g., a ratchet, an actuator, and the like) configured to apply tension to the cable to create traction in the toe. A second actuator may adjust lateral positioning of the pulley relative to the shoe portion to set a desired angle of adduction for the traction provided to the toe by the cable. A meter may be coupled to the cable to indicate an amount of tension provided thereto. Another actuator may adjust elevational positioning of the pulley relative to the shoe portion to set a desired angle of dorsiflexion for the traction provided to the toe by the cable.

Abstract: The present invention relates generally to isolated to arginine deiminase (ADI) proteins that have reduced cross-reactivity with anti-ADI-PEG 20 antibodies as compared to ADI-PEG 20, but which can have functional characteristics comparable to or better than ADI-PEG 20, compositions comprising the ADI proteins, and related methods of treating arginine-dependent diseases or related diseases such as cancer.

Abstract: In device for placing a toe of a patient's foot in traction may broadly include a shoe portion (e.g., a sole, counter, and strap(s)); a toe attachment apparatus (e.g., a Chinese finger trap) having a cable extending therefrom; a pulley, with the cable wrapped about the pulley; and an apparatus (e.g., a ratchet, an actuator, and the like) configured to apply tension to the cable to create traction in the toe. A second actuator may adjust lateral positioning of the pulley relative to the shoe portion to set a desired angle of adduction for the traction provided to the toe by the cable. A meter may be coupled to the cable to indicate an amount of tension provided thereto. Another actuator may adjust elevational positioning of the pulley relative to the shoe portion to set a desired angle of dorsiflexion for the traction provided to the toe by the cable.

Abstract: The present invention relates generally to isolated to arginine deiminase (ADI) proteins that have reduced cross-reactivity with anti-ADI-PEG 20 antibodies as compared to ADI-PEG 20, but which can have functional characteristics comparable to or better than ADI-PEG 20, compositions comprising the ADI proteins, and related methods of treating arginine-dependent diseases or related diseases such as cancer.