Abstract: A method of synthesizing a compound of formula I: comprising the step of reacting a moiety of formula II: with a moiety of formula III: in compressed carbon dioxide in the presence of a transition metal catalyst and a base, wherein L is a labile leaving group; RN1 is optionally substituted C5-20 aryl; RN2 is selected from optionally substituted C5-20aryl, optionally substituted C3-20 heterocyclyl, optionally substituted C3-7 alkyl, and optionally substituted sulfonyl; RN3 is selected from H and optionally substituted C1-7 alkyl, C3-20 heterocyclyl and C5-20 aryl; or RN2 and RN3 together with the nitrogen atom to which they are attached form optionally substituted nitrogen-containing C3-20 heterocylyl or C5-20 heteroaryl; and R1 R2 and R3 are independently selected from optionally substituted C1-7 alkyl, C5-20 aryl, C3-20 heterocyclyl, hydroxy, halo, amino and C1-7 alkoxy, or two of R1, R2 and R3, together with the silicon atom to which they are attached, may form a silicon containing C5-7 heterocyclyl group.

Abstract: The invention relates to a micro-engineered reactor device comprising a closely coupled reactor and electrochemical cell, and a method of using such a reactor for the synthesis of organic compounds by a process involving an electrochemical reaction. The synthetic processes are of a type in which a source material is electrochemically converted to a reactive primary product which is exposed at a reaction region within a channel, or chamber, to a precursor material so that the primary product and precursor material react to generate a secondary product.

Abstract: A chemical reactor and method of using the same. The reactor comprises first and second micro-engineered discrete flow passages for receiving chemical fluids. The first fluid passage receives a first chemical fluid in which a chemical change or reaction in the fluid can be initiated by subjecting the fluid to a stimulus. A stimulation means is located in, or adjacent to, the first flow passage, and is operable to stimulate a chemical change or reaction in the first fluid. The second micro-engineered discrete flow passage receives a second chemical fluid which will interact with the stimulated first fluid when contacted by the stimulated first fluid. The first and second flow passages converge at a first region to form an outlet passage within which the first and second fluids may contact each other.