Patents by Inventor Richard Spaete

Richard Spaete has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NON-SPLICING VARIANTS OF GP350/220
    Publication number: 20130064844
    Abstract: Compositions comprising gp350 variant DNA and amino acid sequences are provided, as are vectors and host cells containing such sequences. Also provided is a process for producing homogeneous gp350 protein recombinantly and in the absence of production of gp220 protein, pharmaceutical compositions containing such protein and prophylactic treatments making use of such proteins.
    Type: Application
    Filed: August 22, 2012
    Publication date: March 14, 2013
    Applicant: MedImmune, LLC
    Inventors: Richard Spaete, Winthrop Jackman
  • NON-SPLICING VARIANTS OF gp350/220
    Publication number: 20120058136
    Abstract: Compositions comprising gp350 variant DNA and amino acid sequences are provided, as are vectors and host cells containing such sequences. Also provided is a process for producing homogeneous gp350 protein recombinantly and in the absence of production of gp220 protein, pharmaceutical compositions containing such protein and prophylactic treatments making use of such proteins.
    Type: Application
    Filed: May 26, 2011
    Publication date: March 8, 2012
    Applicant: MedImmune, LLC
    Inventors: Richard SPAETE, Winthrop Jackman
  • NON-SPLICING VARIANTS OF GP350/220
    Publication number: 20110059486
    Abstract: Compositions comprising gp350 variant DNA and amino acid sequences are provided, as are vectors and host cells containing such sequences. Also provided is a process for producing homogeneous gp350 protein recombinantly and in the absence of production of gp220 protein, pharmaceutical compositions containing such protein and prophylactic treatments making use of such proteins.
    Type: Application
    Filed: March 3, 2010
    Publication date: March 10, 2011
    Applicant: MEDIMMUNE, LLC
    Inventors: Richard SPAETE, Winthrop JACKMAN
  • Attenuation of cytomegalovirus virulence
    Patent number: 7611718
    Abstract: A method is provided for attenuating a cytomegalovirus comprising functionally disrupting an open reading frame of a Toledo genome region or its homolog and making chimeric CMV virus genomes.
    Type: Grant
    Filed: December 20, 2006
    Date of Patent: November 3, 2009
    Assignee: MedImmune, LLC
    Inventors: George Kemble, Gregory M. Duke, Richard Spaete
  • Non-Splicing Variants of gp350/220
    Publication number: 20090263412
    Abstract: Compositions comprising gp350 variant DNA and amino acid sequences are provided, as are vectors and host cells containing such sequences. Also provided is a process for producing homogeneous gp350 protein recombinantly and in the absence of production of gp220 protein, pharmaceutical compositions containing such protein and prophylactic treatments making use of such proteins.
    Type: Application
    Filed: February 11, 2008
    Publication date: October 22, 2009
    Inventors: Richard Spaete, Winthrop Jackman
  • Attenuation of cytomegalovirus virulence
    Patent number: 7550149
    Abstract: A method is provided for attenuating a cytomegalovirus comprising functionally disrupting an open reading frame of a Toledo genome region or its homolog and making chimeric CMV virus genomes.
    Type: Grant
    Filed: December 21, 2006
    Date of Patent: June 23, 2009
    Assignee: MedImmune, LLC
    Inventors: George Kemble, Gregory M. Duke, Richard Spaete
  • Attenuation of cytomegalovirus virulence
    Patent number: 7537770
    Abstract: A method is provided for attenuating a cytomegalovirus comprising functionally disrupting an open reading frame of a Toledo genome region or its homolog and making chimeric CMV virus genomes.
    Type: Grant
    Filed: December 20, 2006
    Date of Patent: May 26, 2009
    Assignee: MedImmune, LLC
    Inventors: George Kemble, Gregory M. Duke, Richard Spaete
  • Attenuation of Cytomegalovirus Virulence
    Publication number: 20080019945
    Abstract: A method is provided for attenuating a cytomegalovirus comprising functionally disrupting an open reading frame of a Toledo genome region or its homolog and making chimeric CMV virus genomes.
    Type: Application
    Filed: December 20, 2006
    Publication date: January 24, 2008
    Applicant: Medlmmune Vaccines, Inc.
    Inventors: George Kemble, Gregory M. Duke, Richard Spaete
  • ATTENUATION OF CYTOMEGALOVIRUS VIRULENCE
    Publication number: 20070292455
    Abstract: A method is provided for attenuating a cytomegalovirus comprising functionally disrupting an open reading frame of a Toledo genome region or its homolog and making chimeric CMV virus genomes.
    Type: Application
    Filed: December 21, 2006
    Publication date: December 20, 2007
    Applicant: MedImmune Vaccines, Inc.
    Inventors: George Kemble, Gregory Duke, Richard Spaete
  • Non-splicing variants of gp350/220
    Publication number: 20070202122
    Abstract: Compositions comprising gp350 variant DNA and amino acid sequences are provided, as are vectors and host cells containing such sequences. Also provided is a process for producing homogeneous gp350 protein recombinantly and in the absence of production of gp220 protein, pharmaceutical compositions containing such protein and prophylactic treatments making use of such proteins.
    Type: Application
    Filed: September 21, 2006
    Publication date: August 30, 2007
    Applicant: MEDIMMUNE, INC.
    Inventors: Richard Spaete, Winthrop Jackman
  • Attenuation of cytomegalovirus virulence
    Patent number: 7204990
    Abstract: A method is provided for attenuating a cytomegalovirus comprising functionally disrupting an open reading frame of a Toledo genome region or its homolog and making chimeric CMV virus genomes.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: April 17, 2007
    Assignee: MedImmune Vaccines, Inc.
    Inventors: George Kemble, Gregory M. Duke, Richard Spaete
  • Novel human cytomegalovirus DNA sequences
    Publication number: 20060240446
    Abstract: Provided are novel Toledo and Towne human cytomegalovirus DNA sequences (HCMV) and proteins encoded thereby. The sequences are useful in methods and compositions for detecting HCMV infections and in immunogenic compositions for Preventing HCMV infections.
    Type: Application
    Filed: December 5, 2005
    Publication date: October 26, 2006
    Applicant: MEDIMMUNE, INC.
    Inventors: Richard Spaete, Tai-An Cha
  • Methods and compositions for treatment and prevention of HSV-2 infections and conditions
    Publication number: 20050112142
    Abstract: Live, attenuated, phenotypically stable HSV-2 viruses and methods of making and using the virus are provided. Live, attenuated HSV-2 viruses are constructed using recombinant techniques and can be used in a pharmaceutical composition for prophylactic treatment of HSV-2 infections and for treatment of recurrent HSV-2 related diseases and conditions.
    Type: Application
    Filed: April 23, 2004
    Publication date: May 26, 2005
    Inventors: Richard Spaete, George Kemble, Bernard Roizman, Mark Prichard
  • Non-splicing variants of gp350/220
    Publication number: 20040137008
    Abstract: Compositions comprising gp350 variant DNA and amino acid sequences are provided, as are vectors and host cells containing such sequences. Also provided is a process for producing homogeneous gp350 protein recombinantly and in the absence of production of gp220 protein, pharmaceutical compositions containing such protein and prophylactic treatments making use of such proteins.
    Type: Application
    Filed: November 25, 2003
    Publication date: July 15, 2004
    Inventors: Richard Spaete, Winthrop Jackman
  • Non-splicing variants of gp350/220
    Patent number: 6692749
    Abstract: Compositions comprising gp350 variant DNA and amino acid sequences are provided, as are vectors and host cells containing such sequences. Also provided is a process for producing homogeneous gp350 protein recombinantly and in the absence of production of gp220 protein, pharmaceutical compositions containing such protein and prophylactic treatments making use of such proteins.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: February 17, 2004
    Assignee: MedImmune Vaccines, Inc.
    Inventors: Richard Spaete, Winthrop Jackman
  • Novel human cytomegalovirus DNA sequences
    Publication number: 20040001850
    Abstract: Provided are novel Toledo and Towne human cytomegalovirus DNA sequences (HCMV) and proteins encoded thereby. The sequences are useful in methods and compositions for detecting HCMV infections and in immunogenic compositions for preventing HCMV infections.
    Type: Application
    Filed: March 21, 2003
    Publication date: January 1, 2004
    Applicant: MedImmune Vaccines, Inc.
    Inventors: Richard Spaete, Tai-An Cha
  • Human cytomegalovirus DNA sequences
    Patent number: 6635477
    Abstract: Provided are novel Toledo and Towne human cytomegalovirus DNA sequences (HCMV) and proteins encoded thereby. The sequences are useful in methods and compositions for detecting HCMV infections and in immunogenic compositions for preventing HCMV infections.
    Type: Grant
    Filed: June 26, 2001
    Date of Patent: October 21, 2003
    Assignee: Med Immune Vaccines, Inc.
    Inventors: Richard Spaete, Tai-An Cha
  • Non-splicing variants of gp350/220
    Patent number: 6458364
    Abstract: Compositions comprising gp350 variant DNA and amino acid sequences are provided, as are vectors and host cells containing such sequences. Also provided is a process for producing homogeneous gp350 protein recombinantly and in the absence of production of gp220 protein, pharmaceutical compositions containing such protein and prophylactic treatments making use of such proteins.
    Type: Grant
    Filed: April 24, 2000
    Date of Patent: October 1, 2002
    Assignee: Aviron
    Inventors: Richard Spaete, Winthrop T. Jackman
  • Recombinant CMV neutralizing proteins
    Publication number: 20020102562
    Abstract: The present invention provides recombinant polypeptides derived from CMV glycoprotein gB and truncated fragments thereof which contain at least one epitope which is immunologically identifiable with one encoded by the CMV genome. The complete characterization of the gB protein, including the identity of glycoprotein gp55, permits the production of polypeptides which are useful as standards or reagents in diagnostic tests and/or as components of vaccines. This invention provides recombinant polypeptides and recombinant polynucleotides encoding these polypeptides wherein a neutralizing epitope of gB is localized within gp55.
    Type: Application
    Filed: February 20, 2001
    Publication date: August 1, 2002
    Applicant: Pasteur Merieux Serums et Vaccines S.A.
    Inventors: Richard Spaete, Carol Pachl
  • Human cytomegalovirus DNA sequences
    Patent number: 6291236
    Abstract: Provided are novel Toledo and Towne Human cytomegalovirus DNA sequences (HCMV) and proteins encoded thereby. The sequences are useful in methods and compositions for detecting HCMV infections and in immunogenic compositions for preventing HCMV infections.
    Type: Grant
    Filed: March 17, 2000
    Date of Patent: September 18, 2001
    Assignee: Aviron
    Inventors: Richard Spaete, Tai-An Cha