Patents by Inventor Richard Steel

Richard Steel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2-AMINOQUINAZOLINONE DERIVATIVES AS METHIONINE ADENOSYLTRANSFERASE 2A INHIBITORS
    Publication number: 20230257377
    Abstract: Disclosed herein are certain 2-aminoquinazoline derivatives of Formula (A) that are methionine adenosyltransferase 2A (MAT2A) inhibitors. Also disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of MAT2A such as cancer, including cancers characterized by reduced or absence of methylthioadenosine phosphorylase (MTAP) activity.
    Type: Application
    Filed: June 9, 2021
    Publication date: August 17, 2023
    Inventors: Richard STEEL, Melissa FLEURY, Paul A. BARSANTI
  • 4-ARYLQUINAZOLINE DERIVATIVES AS METHIONINE ADENOSYLTRANSFERASE 2A INHIBITORS
    Publication number: 20230257359
    Abstract: Disclosed herein are certain 4-arylquinazoline derivatives of Formula (I) that are methionine adenosyltransferase 2A (MAT2A) inhibitors. Also disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of MAT2A such as cancer, including cancers characterized by reduced or absence of methylthioadenosine phosphorylase (MTAP) activity.
    Type: Application
    Filed: June 9, 2021
    Publication date: August 17, 2023
    Inventors: Leah CLEARY, Melissa FLEURY, Zhonghua PEI, Richard STEEL
  • 2-OXOQUINAZOLINE DERIVATIVES AS METHIONINE ADENOSYLTRANSFERASE 2A INHIBITORS
    Publication number: 20220106276
    Abstract: Disclosed herein are certain 2-oxoquinazoline derivatives of Formula (IA): that are methionine adenosyltransferase 2A (MAT2A) inhibitors. Also disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of MAT2A such as cancer, including cancers characterized by reduced or absence of methylthioadenosine phosphorylase (MTAP) activity.
    Type: Application
    Filed: December 9, 2019
    Publication date: April 7, 2022
    Inventors: Muzaffar ALAM, Leah CLEARY, Melissa FLEURY, Zhonghua PEI, Richard STEEL, James SUTTON, John E. KNOX, Zachary E. R. NEWBY
  • 2-oxoquinazoline derivatives as methionine adenosyltransferase 2A inhibitors
    Patent number: 11130759
    Abstract: Disclosed herein are certain 2-oxoquinazoline derivatives of Formula (IA): that are methionine adenosyltransferase 2A (MAT2A) inhibitors. Also disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of MAT2A such as cancer, including cancers characterized by reduced or absence of methylthioadenosine phosphorylase (MTAP) activity.
    Type: Grant
    Filed: February 12, 2021
    Date of Patent: September 28, 2021
    Assignee: IDEAYA BIOSCIENCE, INC.
    Inventors: Muzaffar Alam, Leah Cleary, Melissa Fleury, Zhonghua Pei, Richard Steel, James Sutton, John E. Knox, Zachary E. R. Newby
  • 2-oxoquinazoline derivatives as methionine adenosyltransferase 2A inhibitors
    Patent number: 11084798
    Abstract: Disclosed herein are certain 2-oxoquinazoline derivatives of Formula (IA): that are methionine adenosyltransferase 2A (MAT2A) inhibitors. Also disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of MAT2A such as cancer, including cancers characterized by reduced or absence of methylthioadenosine phosphorylase (MTAP) activity.
    Type: Grant
    Filed: February 12, 2021
    Date of Patent: August 10, 2021
    Assignee: IDEAYA BIOSCIENCES, INC.
    Inventors: Muzaffar Alam, Leah Cleary, Melissa Fleury, Zhonghua Pei, Richard Steel, James Sutton, John E. Knox, Zachary E. R. Newby
  • 2-oxoquinazoline derivatives as methionine adenosyltransferase 2A inhibitors
    Patent number: 11046691
    Abstract: Disclosed herein are certain 2-oxoquinazoline derivatives of Formula (IA): that are methionine adenosyltransferase 2A (MAT2A) inhibitors. Also disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of MAT2A such as cancer, including cancers characterized by reduced or absence of methylthioadenosine phosphorylase (MTAP) activity.
    Type: Grant
    Filed: February 12, 2021
    Date of Patent: June 29, 2021
    Assignee: IDEAYA BIOSCIENCES, INC.
    Inventors: Muzaffar Alam, Leah Cleary, Melissa Fleury, Zhonghua Pei, Richard Steel, James Sutton, John E. Knox, Zachary E. R. Newby
  • TOOL SYSTEM AND TOOL FOR MINING MACHINE
    Publication number: 20130076102
    Abstract: A tool system for a mining machine. The tool comprises a tool holder (12) and a cutting tool pick (14) with a cutting tip (16). The mounting end of the tool comprises a tapered shank (18) in a corresponding tapered socket (20) of the tool holder (12). There may be a wear plate (24) situated between the tool holder (12) and the tool (14). There may be further removable wear plates (30) positioned between the tool holder and the tool in the shank region, these wear plates may have lateral projections (29) engaging corresponding recesses (32) in the shank region of the body (12). All these wear plates may be sacrificial and are able to be replaced upon wear, thus less damage will occur to the shank region of the tool or the holder body. The tool assembly may further include a pin (42) which can engage both the tool and holder by extending through aligned openings, opening (40) in the tool holder and opening (38) in the tool. The pin may be resiliently held in place.
    Type: Application
    Filed: March 18, 2011
    Publication date: March 28, 2013
    Applicant: SOUTHERN ENGINEERING SERVICES PTY LTD
    Inventors: Walter Pizzato, Lincoln Kuiper, Matthew Ross, Paul Wenham, Richard Steel, Michael Johnson