Abstract: The present invention is directed to novel calcium and/or magnesium chelated bisphosphonates, which have improved bioavailability, and less irritation in the GI tract. These bioactive chelated bisphosphonates are useful to treat osteoporosis and other medical disorders previously suggested in the literature.

Abstract: A method of treating a patient having a dermatological condition which comprises administering to the patient a composition comprising a complex characterized as having a maximum water solubility of about 5 wt. % and further characterized as being a complex that is formed by a metathesis reaction between a bioactive monomeric or polymeric cationic molecule with a bioactive monomeric or polymeric anionic molecule or by an acid-base reaction between a bioactive monomeric or polymeric free base and a bioactive monomeric or polymeric acid capable of protonating the free base.

Abstract: This invention describes new and novel bisphosphonate conjugates having anti-inflammatory and/or pain-killing properties.

Abstract: The invention pertains to antimicrobial dental care materials. In particular, the invention pertains to antimicrobial dental care materials containing biocidal complexes, e.g.

Abstract: The present invention is directed to novel and new oral parenteral compositions comprising various bisphosphonates in conjunction with bound or unbound ion exchange resins, or mixtures of the two types of resins thereof. Accordingly, the said dosage forms effect the delivery to the lower intestinal tract in humans or animals prohibiting the exposure of the bisphosphonates to the epithelial and mucosal tissues of the buccal cavity, pharynx, esophagus, and stomach. These drug-resinates also have the systemic effect of providing a slow release mechanism, thereby extending the efficacy of the treatment for a longer period of time. The drug resinates can also incorporate ionic charged bioactive molecules containing carboxylate, amino or positively charged amino groups having synergistic value in conjunction with bisphosphonates.

Abstract: The invention teaches the synthesis of pharmaceutical composition and methods of synthesis to treat people and animals infected with a pathogenic mycobacterium. In particular the compositions of this invention are suitable for the treatment of tuberculosis, malaria, and other infections diseases caused by mycobacterium.

Abstract: Intercalated hydrotalcite-bisphosphonate compositions have improved bioavailability, less irritation in the GI tract and a more constant controlled delivery rate of the active component. These hybrid organic drug—inorganic carrier are useful to build-up skeleton bone and to incorporate into a dentifrice to strengthen the hydroxyapatite mineral on teeth. Added advantages in using hydrotalcite are that it is an excellent anti acid ingredient and certain anionic forms of analgesics vitamins, and pro-vitamins can be intercalated into the clay providing synergy to the bisphosphonate therapy. Other bioactive molecules in their anionic form can also be included, e.g., certain hormones, and nutritional supplements to name a few classes.

Abstract: Piling due to ink, paper fibers and/or clay fillers occurs frequently during an offset printing process, resulting in the deterioration in print quality and lost manual time due to the necessity to clean the equipment. It has been experimentally found that small quantities of certain high molecular weight polyethylene oxide polymers can alleviate this serious problem. However, the overall effectiveness will depend on the concentration of the total make-up of component in the fountain solution.

Abstract: This invention discloses new and novel dermatological compositions synthesized by a metathesis or an acid-base reaction, where both reactants have bioactivity, resulting in improved properties for the treatment of various skin conditions. The novel compositions are preventive as well as therapeutic in alleviating the symptoms of skin disorders associated with disturbed keratinzation or inflammation.

Abstract: This invention relates generally to antiplaque/gingivitis mouth rinses conductive to oral hygiene, and more particularly to a mouth rinse whose formulation includes new compositions whose compositions include a metathesis or acid-base reaction of two well know anti-bacterial agents, or combinations thereof. The novel compositions of this invention can also be used in dentifrice, additive for dental floss, and antimicrobial coatings for sealing fissures, and the like, and for long term protection against caries.

Abstract: Linear, polymeric biguanides or salts thereof wherein the polymeric chain is terminated both at the cyanoguanidine and the amino end groups by either a C2-C140 primary or secondary amine or corresponding cyanoguanidine which is optionally substituted with a halogen, nitro, hydroxy, carbonyl, carboxy, mercapto, sulfoxide, sulfone, sulfonate, sulfide, ether, etc. The di end-cap polymeric biguanides have a high level of biocidal activity accompanied by a low level of toxicity to host organisms and therefore useful as biocides.