Abstract: Disclosed are pharmaceutical compositions comprising a lyophilized compound of formula (I): (I) or a pharmaceutically acceptable salt thereof, and methods of using the same for treating cancer.

Abstract: The invention concerns quinazoline derivatives of the Formula I, or pharmaceutically acceptable salts thereof: wherein each of R1, R2, R3, R4 and m are as defined in the description; processes for their preparation; pharmaceutical compositions containing them and their use in the manufacture of a medicament for providing an anti-proliferative effect. The quinazoline derivatives of Formula I are expected to be useful in the treatment of diseases such as certain cancers mediated by erbB receptor tyrosine kinases, and, for example, EGFR tyrosine kinase.

Abstract: The invention concerns quinazoline derivatives of the Formula I, or pharmaceutically acceptable salts thereof: wherein each of R1, R2, R3, R4 and m are as defined in the description; processes for their preparation; pharmaceutical compositions containing them and their use in the manufacture of a medicament for providing an anti-proliferative effect. The quinazoline derivatives of Formula I are expected to be useful in the treatment of diseases such as certain cancers mediated by erbB receptor tyrosine kinases, and, for example, EGFR tyrosine kinase.

Abstract: The present invention relates to a novel co-crystal of 2-{ethyl[3-({4-[(5-{2-[(3-fluorophenyl)amino]-2-oxoethyl}-1H-pyrazol-3-yl)amino]quinazolin-7-yl}oxy)propyl]amino}ethyl dihydrogen phosphate (AZD1152) which is an aurora kinase inhibitor that is useful in the treatment of hyperproliferative diseases such as cancer.

Abstract: The present invention relates to a novel co-crystal of 2-{ethyl[3-({4-[(5-{2-[(3-fluorophenyl)amino]-2-oxoethyl}-1H-pyrazol-3-yl)amino]quinazolin-7-yl}oxy)propyl]amino}ethyl dihydrogen phosphate (AZD1152) which is an aurora kinase inhibitor that is useful in the treatment of hyperproliferative diseases such as cancer.

Abstract: A tert-butylamine salt, a piperazine salt, a choline salt, a tris(hydroxymethyl)methylamine salt, a lysine salt or an adamantylamine salt of (?)-2-{[2-(4-hydroxyphenyl)ethyl]thio}-3-[4(2-{4-[(methylsulfonyl)oxy]phenoxy}ethyl)phenyl]propanoic acid processes for their preparation, their use in treating clinical conditions including lipid disorders (dyslipidemias) whether or not associated with insulin resistance and other manifestations of the metabolic syndrome, and pharmaceutical compositions containing them.

Abstract: Azithromycin isopropanolate of the empirical formula azithromycin:[H20]x:[isopropanol]y is obtained from the crystallization of azithromycin in isopropanol and water. The x and y values is confirmed by single X-ray diffraction determination. In one embodiment x=1.5 and y=0.25. In another embodiment x=0.75 and y=0.5.

Abstract: The present invention provides an improved process for the preparation of a polymorph of eletriptan hemisulphate.

Abstract: The invention relates anhydrous para-toluenesulphonic acid salts of 3-ethyl-5-[5-(4-ethylpiperazin-1-ylsulphonyl)-2-(2-methoxyethoxy) pyridin-3-yl]-2-(pyridin-2-yl)methyl-2,6-dihydro-7H-pyrazolo [4,3-d]pyrimidin-7-one having the formula (I): a process for preparing compounds (I), pharmaceutical compositions containing (I) and use of (I) in medicine.

Abstract: In order to achieve increased resolution and to minimise cross-colour and cross-luminance effects in a PAL, NTSC or SECAM encoded signal, a high definition source (20) is pre-filtered at a higher line rate according to one of at least two methods (22, 24, 26). The filtered signal is sub-sampled (at 30, 32) at the source line standard where necessary, depending upon the degree of bandwidth reduction employed and one of the methods of pre-filtering and sub-sampling selected according (at 34) to a control signal (36) dependent on picture content. The luminance and chrominance components of the selected encoded signal are band pass filtered (46, 50, 52) and the chrominance signal modulated onto a sub-carrier (54) such that the frequency spectrum of the luminance and chrominance signals do not overlap.

Abstract: A video signal received from a source (10) is bandwidth-compressed by filters (12, 14, 16), filter (14) being a temporal filter and filter (16) being a spatial filter. Selection of the filter to be used is dependent upon picture content. The transmitter reconstitutes in interpolators (44, 46) the signal which would be regenerated at the receiver, determines which filter gives the best results, and transmits an indication of which filter has been used in a digital signal associated with the analogue video signal. Preferably a determination of motion vectors associated with the signal is made and the digital signal indicates which of the determined motion vectors is applicable to different areas of the picture. By transmitting the control signal digitally with the analogue video signal the receiver circuitry is greatly simplified while its reliability is improved.

Abstract: An HDTV video signal with 1249 lines per picture is transmitted over a transmission channel designed for 625 lines per picture by transmitting alternate samples of two lines of the 1249 line signal on a single line of the 625 line signal. An HDTV receiver can interpolate to give a 1249 line picture but a 625 line receiver will still receive a signal that is adequately compatible to give a display.

Abstract: A movement detector for television signals measures the difference between maximum and minimum values of the movement components of a picture difference signal over a chosen interval. A television signal at an input (12) is delayed in a picture delay (2), and the delayed and undelayed signals subtracted in a subtractor (1) to form a picture difference signal. This is rectified in rectifier (3) and smoothed in a filter (4). A maximum detector (6) and a minimum detector (7) are coupled to the filter output and are re-set at prescribed intervals. A subtractor (8) determines the difference between the output of detectors (6) and (7) and this is compared with a reference value in a comparator (9), the output of which is sampled and stored in a store (10).

Abstract: To portray movement in a television display, a field of the signal is stored in an image store (110), and subsequent input fields are compared in a motion detector (104) with the stored field to detect differences between them due to movement. A flag is retained in an auxiliary store (114) to indicate the positions in the field of the detected differences. For those positions for which a new difference is detected, i.e. for which no difference has been detected previously, the corresponding portions of the then current input scan are stored in the image store (110), by a switch (106) being connected to the input (102). For portions which are flagged, the output of the auxiliary store (114) causes the switch (106) to take the output of the image store (110), thus insetting past positions of movement into the current field. The background of the field in the image store is nevertheless updated by the background of the input field.

Abstract: A single field of a PAL color television signal is stored in a store (50) and provides a signal at an input (52). The signal is delayed by one-line delays (56,58) in series to provide one and two-line delayed signals. Separate switching units (60,62) select desired ones or combinations of the input and delayed signals to constitute respectively the low-frequency and chrominance part of the signal at the output (82). The switch positions are changed between fields, and for at least some fields of the PAL sequence each component of the output signal is formed by combining signals from more than one line, i.e. a halving adder (64;66) averages successive lines for the low frequency part of the signal and a halving subtractor (68) forms the difference between lines two lines apart for the chrominance part. The selector unit outputs are combined in an adder (78) which receives the output of the first selector (60), and also the difference between the output of the two selectors after band pass filtering (76).

Abstract: Reduction of noise in a television signal is achieved by comparing signals from successive scans to produce a difference signal. Low amplitude differences are assumed to represent noise and are attenuated. Differences above a predetermined level are assumed to represent movement and are not so attenuated. The attenuation is achieved by a multiplier which receives as multiplier the output of a non-linear transfer characteristic element. The non-linear element receives the differences after rectification and after passing through a variable-gain element. The non-linear element is such that above a predetermined value a constant predetermined minimum attenuation factor applies. A noise measurement circuit measures the noise present in the difference signal and controls the gain of the variable-gain element accordingly. Several noise-measurement circuits may be provided, a selected one of which is used in dependence upon the magnitude of the input signal to the apparatus.

Abstract: Reduction of noise in a television signal is achieved by comparing signals from successive scans to produce a difference signal. Low amplitude differences are assumed to represent noise and are attenuated. Differences above a predetermined level are assumed to represent movement and are not so attenuated. The attenuation is achieved by a multiplier which receives as multiplier the output of a non-linear transfer characteristic element. The non-linear element receives the differences after rectification and after passing through a variable-gain element. The non-linear element is such that above a predetermined value a constant predetermined minimum attenuation factor applies. A noise measurement circuit measures the noise present in the difference signal and controls the gain of the variable-gain element accordingly. Several noise-measurement circuits may be provided, a selected one of which is used in dependence upon the magnitude of the input signal to the apparatus.