Abstract: The invention generally relates to systems, methods, and devices for ex vivo organ care. More particularly, in various embodiments, the invention relates to caring for a liver ex vivo at physiologic or near-physiologic conditions.

Abstract: Methods, systems and apparatus are provided for facilitating financial transactions using an IC type financial card presented at a terminal. A requested transaction for monetary value is processed via a first transaction type. If the transaction is successful, monetary value (such as cash or a monetary value ticket or receipt) is dispensed to the user. If unsuccessful, the card is not ejected and the transaction is processed via a second transaction type. The first transaction type might be a PIN based ATM or ticket transaction and the second transaction type might be a signature based transaction.

Abstract: Provided herein is a high throughput screening method for identifying guide RNAs (gRNAs) useful for editing a target RNA, wherein the editing is mediated by an RNA editing entity (e.g., a native human adenosine deaminase enzyme for a human subject).

Abstract: The invention relates to compounds of formula I wherein R1, R2 and - - - - - are as defined herein, pharmaceutical compositions comprising the compounds and methods of treating COVID-19 in a patient by administering therapeutically effective amounts of the compounds and methods of inhibiting or preventing replication of SARS-CoV-2 with the compounds.

Abstract: Techniques for managing an application token may include providing, by a first service provider application on a communication device to a first service provider computer, a first request for a first application token, receiving, by an account management application on the communication device from a token service computer in communication with the first service provider computer, the first application token, and storing the first application token in a token container in the account management application.

Abstract: Provided herein are engineered latent guide RNAs that bind target RNAs to form a guide-target RNA scaffold and are substrates for RNA editing entities, which chemically modify the base of a nucleotide of the target RNA. Also provided herein are compositions, vectors, and cells comprising the engineered latent guide RNAs disclosed herein and methods of use thereof.

Abstract: Disclosed herein are compositions that comprise engineered polynucleotides, pharmaceutical compositions comprising the same, methods of making the same, and methods of treatment comprising the compositions that comprise the engineered polynucleotides.

Abstract: The invention provides oral care compositions, for example a dentifrice or mouthwash, comprising zinc phosphate, wherein the zinc phosphate is added to the dentifrice or mouthwash as a preformed salt; as well as methods of making and using the same.

Abstract: Provided herein are compositions and methods that can be utilized to ameliorate, treat, or at least partially eliminate diseases and conditions that can arise from genomic mutations. Subject compositions and methods can be used to edit RNA to ameliorate, treat, or at least partially eliminate the disease and conditions in a subject.

Abstract: Disclosed herein are engineered guide RNAs, engineered polynucleotides, precursor engineered polynucleotide, vectors omprising engineered polynucleotide, nucleic acids of engineered polynucleotide, pharmaceutical compositions thereof, methods of making the engineered polynucleotides and methods of treating or preventing a disease or condition by administering above described thereof.

Abstract: Disclosed herein are compositions that comprise engineered polynucleotides, pharmaceutical compositions comprising the same, methods of making the same, and methods of treatment comprising the compositions that comprise the engineered polynucleotides.

Abstract: Provided herein is a method for removing a chemical stain from a dental surface or inhibiting chemical staining of a dental surface, comprising contacting the dental surface with an oral care composition comprising zinc phosphate and an orally acceptable carrier.

Abstract: An oral care composition comprising zinc phosphate and stannous fluoride.

Abstract: The invention provides oral care compositions, for example a dentifrice or mouthwash, comprising zinc phosphate, wherein the zinc phosphate is added to the dentifrice or mouthwash as a preformed salt; as well as methods of making and using the same.

Abstract: An oral care composition is disclosed. The composition comprises zinc phosphate and a silicate compound comprising a metallic element that in cationic form is capable of reducing tooth enamel erosion. The zinc phosphate is added to the oral care composition as a preformed salt. Methods of administering the oral care compositions to subjects in need thereof are also disclosed.

Abstract: Provided are CCT5-binding molecules, including anti-CCT5 antibodies and antigen- binding fragments thereof such as heavy chain variable (VH) regions and single-chain antibody fragments, and conjugates comprising the anti-CCT5 binding molecules such as immunoconjugates and antibody-drug conjugates, and chimeric receptors comprising the anti-CCT5 binding molecules such as chimeric antigen receptors (CARs). In some embodiments, the anti-CCT5 antibodies or antigen-binding fragments thereof specifically bind to CCT5. Also provided are genetically engineered cells expressing the CARs or CCT5-binding molecules and uses thereof such as in adoptive cell therapy.

Abstract: The invention provides a pre-insulated duct having a length and comprising a tube having a foam layer. The pre-insulated duct has an interior face and an exterior face and a thickness defined as a distance between the interior face and the exterior face. The interior face of the pre-insulated duct bounds an airflow space. In the present group of embodiments, the pre-insulated duct has a mounting rail system extending along the length of the pre-insulated duct. The mounting rail system includes at least one mounting rail, and preferably a plurality of mounting rails, positioned on (e.g., positioned on an exterior of) the pre-insulated duct.

Abstract: Provided herein is a method for removing a chemical stain from a dental surface or inhibiting chemical staining of a dental surface, comprising contacting the dental surface with an oral care composition comprising zinc phosphate and an orally acceptable carrier.

Abstract: Provided herein is a method for removing a chemical stain from a dental surface or inhibiting chemical staining of a dental surface, comprising contacting the dental surface with an oral care composition comprising zinc phosphate and an orally acceptable carrier.

Abstract: Described herein are aqueous oral care compositions comprising (a) an effective amount of a basic amino acid in free or orally acceptable salt form; and (b) a polymer system comprising (i) a cellulosic polymer, (ii) a gum polymer, and (iii) a polyacrylate polymer or co-polymer; and methods of making and using the same.