Abstract: A method for traversing an anatomical vessel wall of a subject is provided. The invention allows the crossing of a wire from one anatomical lumen, such as an artery, vein, esophagus, intestine or airway, through tissue, into another anatomical lumen, or cavity, or into a solid mass of tissue. In some aspects, the invention allows the crossing of a wire from the greater cardiac vein (GCV) into the left atrium without relying on another device in the left atrium to facilitate the crossing.

Abstract: Delivery systems, methods and associated devices to facilitate delivery and deployment of a heart implant. Such delivery systems and methods of delivery include use of a pair of magnetic catheters, including an anchor delivery catheter carrying an anchor, which can be stacked with or can be axially offset from the magnetic head. Such systems further include use of a puncturing guidewire advanceable through the magnetic head of the anchor delivery catheter to establish access to a chamber of a heart and which is attached to a bridging element such that continued advancement of the guidewire draws a bridging element attached to the first anchor across the chamber of the heart while the bridging element remains covered by the magnetically coupled catheters. Methods and devices herein also allow for cutting and removal of a bridge element of a deployed heart implant.

Abstract: Anchors for securing an implant within a body organ and/or reshaping a body organ are provided herein. Anchors are configured for deployment in a body lumen or vasculature of the patient that are curved or conformable to accommodate anatomy of the patient. The invention provides an implant system having multiple anchors, e.g., one or more posterior anchors in combination with one or more anterior anchors. Methods of deploying such anchors, and use of multiple anchors or multiple bridging elements are also provided.