Abstract: An apparatus and method for terminal sterilization of prefilled packages is disclosed. A prefilled package such as syringe, vial, cartridge, or bottle is inserted into a sterilization chamber. The chamber is pressurized with a gas having a humidity between 0% to 100%. The gas is then heated such that the prefilled package does not fail and a vapor is generated within said prefilled package which is lethal to pathogens. The package is then cooled to drop the temperature of the prefilled package.

Abstract: Disclosed are pre-filled syringes equipped with an improved plunger and a plunger rod, characterized by a leak-proof seal and easy sliding property.

Abstract: Disclosed are pre-filled syringes equipped with an improved plunger, a plunger actuating cylinder and a plunger rod, characterized by a leak-proof seal and easy sliding property.

Abstract: A human powered mechanism for propelling a wheeled land vehicle, a water vehicle (a boat or hydroplane) using either a water screw or a jet of water or an ultra-light aircraft with an air screw. The mechanism can utilize either arm or leg muscles or preferably, both arms and legs extending and retracting in a manner similar to walking or running as performed from a semi-recumbent position. Steering or other critical control is accomplished through another mechanism which is guided by the appropriate movement of the operator's head. The operators feet are placed on pedals which are attached to swinging members which pivot in a bearing at the upper end. The operator's hands grasp leverage arms which are cantilevered, the distal ends of which are attached to the same push-pull connecting rods as the above mentioned swinging members with foot pedals attached.

Abstract: A self-aspirating plunger for power injector cartridges characterized by its ability to pump head space gas and aspirate the power injector cartridge without the need to draw backward on the plunger toward the proximal end of the cartride comprising:a female ring component;a male component having a stem and a cone-shaped portion, said stem slideably fitting into said female ring component; andan elastomeric diaphragm shell covering said female ring component and said cone shaped head portion of said male component.

Abstract: Disclosed is a pre-filled plastic syringe containing a liquid product for terminal sterilization comprising: a syringe barrel equipped with a one-way valve and a slidable plunger to equalize pressure differentials; a filter engaging the one way valve to prevent backward migration of viruses and bacteria; an end cap covering the open end of the barrel to maintain sterility; and an end cap restraining device to prevent plunger blow-out.

Abstract: Disclosed is a stopper for a medical vial suitable for piercings by a spike without producing unacceptable amounts of particulate matter, comprising: a stopper body of an elastomeric material; and an abrasion resistant coating covering the top, central, piercable surface of the stopper.

Abstract: Disclosed is a method for terminal steam sterilization of a pre-filled plastic syringe or a pre-filled plastic cartridge, said method comprising the steps of: maintaining a head space in the syringe or cartridge of less than about 10%--of the fill--volume; providing at least a 10% leeway for the plunger therein to slide in response to pressure differential; and sterilizing the syringe or cartridge at an autoclave pressure that is less than the internal pressure of the syringe or cartridge.