Abstract: A neuromodulation therapy is delivered via at least one electrode implanted subcutaneously and superficially to a fascia layer superficial to a nerve of a patient. In one example, an implantable medical device is deployed along a superficial surface of a deep fascia tissue layer superficial to a nerve of a patient. Electrical stimulation energy is delivered to the nerve through the deep fascia tissue layer via implantable medical device electrodes.

Abstract: A neuromodulation therapy is delivered via at least one electrode implanted subcutaneously and superficially to a fascia layer superficial to a nerve of a patient. In one example, an implantable medical device is deployed along a superficial surface of a deep fascia tissue layer superficial to a nerve of a patient. Electrical stimulation energy is delivered to the nerve through the deep fascia tissue layer via implantable medical device electrodes.

Abstract: A method of capturing radiographic images by wirelessly synchronizing steps performed by first and second components of a radiographic imaging system. Digital messages are sent between the first and second components and the send and receive times are recorded so that a transmission delay time and clock drift rate may be determined. A schedule of first component steps and a schedule of second component steps are generated based on the send and receive times, the transmission delay time and the clock drift rate.

Abstract: A digital radiographic detector outputs positive read out signals that may oscillate. The presence of negative going portions of the read out signals may be used to determine that the detected positive signals are a result of noise, while an absence of the negative going portions may be used to determine that x-rays are impacting the detector.

Abstract: A digital radiographic detector outputs positive read out signals that may oscillate. The presence of negative going portions of the read out signals may be used to determine that the detected positive signals are a result of noise, while an absence of the negative going portions may be used to determine that x-rays are impacting the detector.

Abstract: A system for monitoring the state of calibration of a digital x-ray detector having a solid state sensor with a plurality of pixels, a scintillating screen and at least one embedded microprocessor, the system having means for capturing a digital image and a computer operable during normal diagnostic use of the detector, in cooperation with at least one embedded microprocessor, for performing pixelwise computations on the image and calculating a misregistration metric indicative of movement of the solid state sensor relative to the scintillating screen. A defect metric indicative of abnormal properties of pixels in the solid state sensor is calculated. It is then determined whether one or both of the misregistration metric and the defect metric exceeds a respective, preselected threshold value. The user of the system is alerted to conduct a calibration of the detector when either one or both of the respective threshold values have been exceeded.

Abstract: A method of reducing artifacts in a digital radiographic image identifies either a row or column direction for the artifacts in the image data as a predominant direction and obtains a measurement of the image data frequency content that is subject to artifacts from the image content according to the predominant direction. The measurement of image data frequency content subject to the artifacts is tested according to a predetermined threshold. Artifacts are reduced when the predetermined threshold is exceeded by generating one or more suppression factors according to the testing results, decomposing the image content into at least two frequency bands in each row and column direction, applying the one or more suppression factors to modify at least one of the frequency bands, and recomposing the image content by recombining the at least one modified frequency band with one or more other bands into which the image had been decomposed.

Abstract: A system for monitoring the state of calibration of a digital x-ray detector having a solid state sensor with a plurality of pixels, a scintillating screen and at least one embedded microprocessor, the system having means for capturing a digital image and a computer operable during normal diagnostic use of the detector, in cooperation with at least one embedded microprocessor, for performing pixelwise computations on the image and calculating a misregistration metric indicative of movement of the solid state sensor relative to the scintillating screen. A defect metric indicative of abnormal properties of pixels in the solid state sensor is calculated. It is then determined whether one or both of the misregistration metric and the defect metric exceeds a respective, preselected threshold value. The user of the system is alerted to conduct a calibration of the detector when either one or both of the respective threshold values have been exceeded.

Abstract: The present invention is directed to methods for determining the presence or absence of a genetic defect in an IVF embryo prior to transfer comprising performing real-time PCR and 2???CT analyses to determine normalized copy number of at least one invariant locus on at least one chromosome collected from at least one cell of the embryo and selecting a candidate IVF embryo determined to be without genetic defect for transfer.

Abstract: A method of forming an offset-corrected exposure image includes obtaining an initial exposure image and exposure metadata related to the initial exposure image. An intermediate offset-corrected exposure image is formed by obtaining one or more dark images associated with the initial exposure image and subtracting an averaged value of the one or more dark images from the initial exposure image. The offset-corrected exposure image is obtained by combining an offset adjustment map with the intermediate offset-corrected exposure image.

Abstract: The present invention is directed to methods for determining the presence or absence of a genetic defect in an IVF embryo prior to transfer comprising identifying a set of informative SNPs in the genotype of the embryo's parents; assaying the genotype of two or more informative SNPs from the set of informative SNPs on one or more chromosomes collected from a cell of the embryo; determining the presence or absence of a genetic defect in the embryo based on the genotype of the two or more informative SNPs on one or more chromosomes of the embryo; and selecting a candidate IVF embryo determined to be without genetic defect for transfer.

Abstract: Methods of in vitro fertilization wherein said method includes preimplantation genetic diagnosis of all 24 chromosomes of an IVF embryo comprising whole genome amplification and SNP-based microarray analyses are disclosed.

Abstract: A method of reducing artifacts in a digital radiographic image identifies either a row or column direction for the artifacts in the image data as a predominant direction and obtains a measurement of the image data frequency content that is subject to artifacts from the image content according to the predominant direction. The measurement of image data frequency content subject to the artifacts is tested according to a predetermined threshold. Artifacts are reduced when the predetermined threshold is exceeded by generating one or more suppression factors according to the testing results, decomposing the image content into at least two frequency bands in each row and column direction, applying the one or more suppression factors to modify at least one of the frequency bands, and recomposing the image content by recombining the at least one modified frequency band with one or more other bands into which the image had been decomposed.

Abstract: A method of forming an offset-corrected exposure image includes obtaining an initial exposure image and exposure metadata related to the initial exposure image. An intermediate offset-corrected exposure image is formed by obtaining one or more dark images associated with the initial exposure image and subtracting an averaged value of the one or more dark images from the initial exposure image. The offset-corrected exposure image is obtained by combining an offset adjustment map with the intermediate offset-corrected exposure image.