Patents by Inventor Richard Tavaré

Richard Tavaré has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ENGINEERED ANTIBODY FRAGMENTS FOR TARGETING AND IMAGING CD8 EXPRESSION IN VIVO
    Publication number: 20150191543
    Abstract: Disclosed herein, the parental antibodies from the hybridomas YTS 169.4.2.1 (YTS169) and 2.43 were engineered into minibody and diabody fragments. Both the YTS and 2.43 antibodies bind mCD8+. However, they differ in that the YTS 169 antibodies bind both Lyt2.1 and Lyt2.2 while the 2.43 antibodies bind an epitope that is Lyt2.2 specific. These novel minibodies and diabodies retained their antigen specificity as shown by flow cytometry and ImmunoPET imaging. Most importantly, both the 2.43 and YTS169 minibodies and diabodies produced high contrast ImmunoPET images of CD8+ lymphoid organs at only four hours post-injection.
    Type: Application
    Filed: August 6, 2013
    Publication date: July 9, 2015
    Inventors: Anna M. Wu, Richard Tavaré, Tove Olafsen