Abstract: Targeted Factor VIII molecules comprising a Factor VIII linked with at least one domain that specifically binds to a membrane protein on a red blood cell is provided. The disclosed targeted coagulation factors prolong their duration of action and thus, are an improvement for the treatment of hematological diseases such as hemophilia A.

Abstract: Provided herein are antibodies, or antigen binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen binding portions thereof.

Abstract: There is provided a method for establishing a connection between a Neutral Host (NH) network and one or more virtual radio access networks (vRANs), under a service level agreement (SLA) therebetween. The method comprises: sending a message to the one or more vRANs, the message including an identity of the NH network and at least a first radio parameter; in response to the message, receiving an identity of the one or more vRANs and at least a second radio parameter; and establishing the connection between the NH network and the one or more vRANs, based on the identity of the one or more vRANs, the identity of the NH network and one of the at least first radio parameter and the at least second radio parameter. The method is implemented in a network node, such as a Distributed Unit of a gNB.

Abstract: The present invention relates to a hair straightening apparatus having two arms pivotably coupled together and a heating plate on a facing side of at least one arm. A central pack disposed between the first arm and the second arm and coupled to the hair styling apparatus at the hinge end and a biasing means adapted to support the central pack symmetrically between the first arm and the second arm.

Abstract: The present invention allows dental professionals to more efficiently and effectively control contaminants not only at the source of their creation (the mouth, for example), with optional configurations that comprise tiered guarding layers to protect the patient, the dentist, the dental assistant, the dental hygienist, as well as other dental professionals/staff, other patients, and subsequent patients to be treated in that operatory.

Abstract: A virtual haptic simulator enabling individuals to work on model teeth to create preparations and/or restorations. The virtual haptic simulator interfaces to a comparing system that can evaluate augmentations performed on the model teeth to ideal targets that are intended as the result.

Abstract: The present invention relates to a herbicidal composition which comprises: a) at least one herbicide A selected from glyphosate, glufosinate and their salts, and b) a herbicide B which is 3-[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)pyrazol-4-ylmethylsulfonyl]-4,5-dihydro-5,5-dimethyl-1,2-oxazole [common name: pyroxasulfone]. The present invention relates in particular to a herbicidal composition comprising: a) at least one herbicide A selected from glyphosate, glufosinate and their salts, b) a herbicide B which is 3-[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)pyrazol-4-ylmethylsulfonyl]-4,5-dihydro-5,5-dimethyl-1,2-oxazole [common name: pyroxasulfone], and c) at least one further herbicide C, which is selected from the herbicide groups C.1 to C.8: C.1 herbicides of the group of acetolactate synthase inhibitors (ALS inhibitors), C.2 herbicides of the group of protoporphyrinogen oxidase inhibitors (PPO inhibitors), C.3 herbicides of the group of auxines, C.

Abstract: The present disclosure relates to a tensioning system for use in a stereolithography manufacturing application. The system may have a build plate for supporting a three dimensional part being formed using a photo responsive resin, a base plate and a release element extending over the base plate. The release element is configured to receive a quantity of photo responsive resin for forming a new material layer of the three dimensional part. A pair of tensioning components are secured to opposite ends of the release element, and apply a controlled tension force to the release element during peeling of the release element to reduce a separation force required to separate the release element from the new material layer after the new material layer is cured.

Abstract: A method according to one embodiment includes securing a first plurality of conductive sheets to a surface, applying a conductive tape to a first plurality of joints between conductive sheets of the first plurality of conductive sheets, and securing a second plurality of conductive sheets to the first plurality of conductive sheets without fully penetrating the first plurality of conductive sheets. In such an embodiment, each of a second plurality of joints between conductive sheets of the second plurality of conductive sheets is offset relative to the first plurality of joints.

Abstract: A method for manufacturing a part includes fabricating an object in an additive fabrication stage, the object including a solid mold forming a cavity in the shape of a part with uncured or incompletely cured build material disposed therein. The build material in the cavity is cured in a curing stage that occurs at least partially after the additive fabrication stage. The build material undergoes a phase change mechanism occurring during the additive fabrication stage and a distinct polymerization mechanism occurring during the curing stage and at least partly after the additive fabrication stage of the object and cures the build material by a polymerization process.

Abstract: This invention is in the area of improved anti-aP2 antibodies and antigen binding agents, and compositions thereof, which target the lipid chaperone aP2/FABP4 (referred to as “aP2”) for use in treating disorders such as diabetes, obesity, cardiovascular disease, fatty liver disease, and/or cancer, among others. In one aspect, improved treatments for aP2 mediated disorders are disclosed in which serum aP2 is targeted and the biological activity of aP2 is neutralized or modulated using low-binding affinity aP2 monoclonal antibodies, providing lower fasting blood glucose levels, improved systemic glucose metabolism, increased systemic insulin sensitivity, reduced fat mass, reduced liver steatosis, reduced cardiovascular disease and/or a reduced risk of developing cardiovascular disease.

Abstract: Systems and methods described herein employ focused acoustic energy applied to a reservoir containing a fluid to eject a fluid sample from the fluid sample reservoir, e.g. to an inlet of an analytical device. In many embodiments, the ejected fluid sample traverses an air gap separating the inlet of the analytical device from an upper surface of the fluid in the fluid sample reservoir. In many embodiments, the ejected fluid sample comprises one or more droplets ejected from the fluid sample reservoir, which can contain particles suspended in the fluid sample.

Abstract: A device is provided for feeding sheets to a sheet-processing machine having at least one processing mechanism. A feeder head is provided for cyclically separating the sheets from a pile of such sheets and has transporting suckers for transporting the sheets to a belt table. The belt table has at least one revolving transport belt which is guided over at least two feed rollers. A first drive is assigned to at least one feed roller and a sheet flap, which is connected to a pivotally mounted shaft, is provided between the transporting suckers and the at least one transport belt. A second drive is assigned to the shaft, for pivoting that shaft. A sheet arrival sensor, which is arranged between the belt table and the processing mechanism, generates first signals representing the arrival of the sheets for a sequence of sheets.

Abstract: The present disclosure provides an apparatus comprising a housing with a left side panel, right side panel, and top panel, each of which may comprise a slot. The apparatus may comprise a front panel that is insertable into the slots of the left and right-side panels. The front panel may comprise a recessed region configured to receive a portion of a medical instrument. A source of a barrier material may be supported by the left and right-side panels. The apparatus may comprise a lid cover comprising a roller portion that is insertable into a slot of the top panel. The lid cover may pivot relative to the housing when the roller portion is inserted into the slot of the top panel. The lid cover and the front panel may form a gap through which a portion of the barrier material may extend when the barrier material is dispensed.

Abstract: A transparent conductive film (TCF) and methods for creating the TCF. The TCF includes a substrate having a surface, a metal mesh layer over at least a portion of the surface of the substrate, and a conductive layer over the metal mesh layer. The conductive layer includes carbon nanotubes and a binder.

Abstract: The compound (S)-1-(5-((2,3-dihydro-[1,4]dioxino[2,3-b]pyridin-7-yl)sulfonyl)-3,4,5,6-tetrahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-3-hydroxy-2-phenylpropan-1-one, or a pharmaceutically acceptable salt thereof, is useful to increase the affinity of hemoglobin for oxygen. Methods and compositions for the treatment of a hemoglobinopathies are provided herein, including certain pharmaceutical compositions for activating PKR.

Abstract: Medical devices and methods for delivering fluid. The medical devices include one or more needles for delivering fluid. The methods may include expanding an expandable member such as an inflatable member to expand an expandable scaffold outward toward a lumen wall.

Abstract: A storage device includes: a storage controller to receive one or more notifications corresponding to host data transferred from a host device to the storage device over a storage interface; and a response circuit connected to the storage controller, the response circuit to trigger a response to the host device, and including: a first counter to track the one or more notifications, the one or more notifications corresponding to an entirety of the host data such that each of the notifications corresponds to a portion of the host data; a second counter to track one or more acknowledgements received from the storage controller, the one or more acknowledgments corresponding to the one or more notifications such that each of the acknowledgments corresponds to a notification; and a response trigger to select one of the first counter and the second counter to trigger the response to the host device.

Abstract: A model tooth, that is constructed with multiple layers of material. The object is designed for a particular procedure, such as removal of material to repair a cavity. The 3D area to be removed is provided in a first color, the area bordering the material to be removed is provided in a second color and the area on past the border is provided in a third color. Advantageously, upon performance of a procedure, the object can be visually inspected to determine if all of the first color material is removed, without over removing the material of the second color.

Abstract: Techniques for behavioral pairing in a contact center system are disclosed. In one particular embodiment, the techniques may be realized as a method for behavioral pairing in a contact center system comprising: determining, by at least one computer processor communicatively coupled to and configured to operate in the contact center system, a plurality of contacts available for connection to an agent; determining, by the at least one computer processor, a plurality of preferred contact-agent pairings among possible pairings between the agent and the plurality of contacts; selecting, by the at least one computer processor, one of the plurality of preferred contact-agent pairings according to a probabilistic network flow model; and outputting, by the at least one computer processor, the selected one of the plurality of preferred contact-agent pairings for connection in the contact center system.