Patents by Inventor Richard Theolis

Richard Theolis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti-PVRIG antibodies and methods of use
    Patent number: 12312404
    Abstract: The present invention is directed to anti-PVRIG antibodies and methods of using same.
    Type: Grant
    Filed: August 11, 2023
    Date of Patent: May 27, 2025
    Assignee: Compugen Ltd.
    Inventors: Mark White, Sandeep Kumar, Christopher Chan, Spencer Liang, Lance Stapleton, Andrew W. Drake, Yosi Gozlan, Ilan Vaknin, Shirley Sameah-Greenwald, Liat Dassa, Zohar Tiran, Gad S. Cojocaru, Leonard Presta, Richard Theolis
  • Antibodies directed to Tie-2 and methods of use
    Patent number: 12195542
    Abstract: The invention relates to anti-Tie2 antibodies and methods of using the same.
    Type: Grant
    Filed: November 19, 2020
    Date of Patent: January 14, 2025
    Assignee: Unity Biotechnology, Inc.
    Inventors: Jason Damiano, Kristina Oresic Bender, Richard Theolis, Deepika Bhatnagar, Nina Ly
  • Antibodies Directed to TIE-2 and Methods of Use
    Publication number: 20240392012
    Abstract: The invention relates to anti-Tie2 antibodies and methods of using the same.
    Type: Application
    Filed: March 5, 2024
    Publication date: November 28, 2024
    Inventors: Jason Damiano, Kristina Oresic Bender, Richard Theolis, Deepika Bhatnagar, Nina Ly
  • ANTI-TIGIT ANTIBODIES, ANTI-PVRIG ANTIBODIES AND COMBINATIONS THEREOF
    Publication number: 20240139318
    Abstract: Anti-PVRIG and anti-TIGIT antibodies are provided.
    Type: Application
    Filed: August 21, 2023
    Publication date: May 2, 2024
    Inventors: Mark White, Sandeep Kumar, Christopher Chan, Spencer Liang, Lance Stapleton, Andrew W. Drake, Yosi Gozlan, Ilan Vaknin, Shirley Sameah-Greenwald, Liat Dassa, Zohar Tiran, Gad S. Cojocaru, Maya Kotturi, Hsin-Yuan Cheng, Kyle Hansen, David Nisim Giladi, Einav Safyon, Eran Ophir, Leonard Presta, Richard Theolis, Radhika Desai, Patrick Wall
  • ANTI-PVRIG ANTIBODIES AND METHODS OF USE
    Publication number: 20240101669
    Abstract: The present invention is directed to anti-PVRIG antibodies and methods of using same.
    Type: Application
    Filed: August 11, 2023
    Publication date: March 28, 2024
    Inventors: Mark White, Sandeep Kumar, Christopher Chan, Spencer Liang, Lance Stapleton, Andrew W. Drake, Yosi Gozlan, Ilan Vaknin, Shirley Sameah-Greenwald, Liat Dassa, Zohar Tiran, Gad S. Cojocaru, Leonard Presta, Richard Theolis
  • ANTI-TIGIT ANTIBODIES, ANTI-PVRIG ANTIBODIES AND COMBINATIONS THEREOF
    Publication number: 20240075137
    Abstract: Anti-PVRIG and anti-TIGIT antibodies are provided.
    Type: Application
    Filed: May 23, 2023
    Publication date: March 7, 2024
    Inventors: Mark White, Sandeep Kumar, Christopher Chan, Spencer Liang, Lance Stapleton, Andrew W. Drake, Yosi Gozlan, Ilan Vaknin, Shirley Sameah-Greenwald, Liat Dassa, Zohar Tiran, Gad S. Cojocaru, Maya Kotturi, Hsin-Yuan Cheng, Kyle Hansen, David Nisim Giladi, Einav Safyon, Eran Ophir, Leonard Presta, Richard Theolis, Radhika Desai, Patrick Wall
  • Anti-PVRIG antibodies and methods of use
    Patent number: 11795220
    Abstract: The present invention is directed to anti-PVRIG antibodies and methods of using same.
    Type: Grant
    Filed: June 17, 2020
    Date of Patent: October 24, 2023
    Assignee: COMPUGEN LTD.
    Inventors: Mark White, Sandeep Kumar, Christopher Chan, Spencer Liang, Lance Stapleton, Andrew W. Drake, Yosi Gozlan, Ilan Vaknin, Shirley Sameah-Greenwald, Liat Dassa, Zohar Tiran, Gad S. Cojocaru, Leonard Presta, Richard Theolis
  • ANTI ABCC1 ANTIBODIES AND USES THEREOF
    Publication number: 20230272117
    Abstract: Provided are antibodies that target the cellular efflux pump ABCC1. Also provided are pharmaceutical compositions, nucleic acids, recombinant expression vectors, cells, and kits that include or encode such antibodies. Methods of using the antibodies for detecting presence or absence of ABCC1 expression in cells, e.g., tumor cells, Level of ABCC1 expression, and/or inhibiting ABCC1 function are also disclosed. Also provided are methods for treating a subject for a cancer that include administering to the subject an anti-ABCC1 antibody disclosed herein. The subject antibody may be a bispecific antibody. The bispecific antibody may bind to ABCC1 and a tumor associated antigen (TAA).
    Type: Application
    Filed: September 1, 2021
    Publication date: August 31, 2023
    Inventors: William Robert Arathoon, Raffaella Briante, Paul David Ponath, Cindy Tan, Richard Theolis, Qianting Zhai, Pingping Zhang
  • Anti-TIGIT antibodies, anti-PVRIG antibodies and combinations thereof
    Patent number: 11701424
    Abstract: Anti-PVRIG and anti-TIGIT antibodies are provided.
    Type: Grant
    Filed: June 17, 2020
    Date of Patent: July 18, 2023
    Assignee: COMPUGEN LTD.
    Inventors: Mark White, Sandeep Kumar, Christopher Chan, Spencer Liang, Lance Stapleton, Andrew W. Drake, Yosi Gozlan, Ilan Vaknin, Shirley Sameah-Greenwald, Liat Dassa, Zohar Tiran, Gad S. Cojocaru, Maya Kotturi, Hsin-Yuan Cheng, Kyle Hansen, David Nisim Giladi, Einav Safyon, Eran Ophir, Leonard Presta, Richard Theolis, Radhika Desai, Patrick Wall
  • ANTI-ABCG2 ANTIBODIES AND USES THEREOF
    Publication number: 20230212305
    Abstract: Provided are antibodies that target the cellular efflux pump ABCG2. Also provided are pharmaceutical compositions, nucleic acids, recombinant expression vectors, cells, and kits that include or encode such antibodies. Methods of using the antibodies for detecting presence or absence of ABCG2 expression in cells, e.g., tumor cells, level of ABCG2 expression, and/or inhibiting ABCG2 function are also disclosed. In addition, multi-specific antibodies that bind to ABCG2 and a polypeptide expressed on surface of a cancer cell are provided. The polypeptide may be the efflux pump MDR1 or a cancer-associated antigen. Also provided are methods for treating a subject for a cancer that include administering to the subject an anti-ABCG2 antibody as disclosed herein or a multi-specific antibody that targets both ABCG2 and a cancer-associated antigen or MDR1.
    Type: Application
    Filed: May 28, 2021
    Publication date: July 6, 2023
    Inventors: William Robert Arathoon, Raffaella Briante, Suchismita Mohanty, Paul David Ponath, Richard Theolis, Qianting Zhai, Pingping Zhang
  • Anti-PVRIG antibodies and methods of use
    Patent number: 11623955
    Abstract: The present invention is directed to anti-PVRIG antibodies and methods of using same.
    Type: Grant
    Filed: January 21, 2020
    Date of Patent: April 11, 2023
    Assignee: COMPUGEN LTD.
    Inventors: Mark White, Sandeep Kumar, Christopher Chan, Spencer Liang, Lance Stapleton, Andrew W. Drake, Yosi Gozlan, Ilan Vaknin, Shirley Sameah-Greenwald, Liat Dassa, Zohar Tiran, Gad S. Cojocaru, Leonard Presta, Richard Theolis
  • Anti-PVRIG antibodies and methods of use
    Patent number: 11220542
    Abstract: The present invention is directed to anti-PVRIG antibodies and methods of using same.
    Type: Grant
    Filed: September 27, 2016
    Date of Patent: January 11, 2022
    Assignee: Compugen Ltd.
    Inventors: Mark White, Sandeep Kumar, Christopher Chan, Spencer Liang, Lance Stapleton, Andrew W. Drake, Yosi Gozlan, Ilan Vaknin, Shirley Sameah-Greenwald, Liat Dassa, Zohar Tiran, Gad S. Cojocaru, Leonard Presta, Richard Theolis
  • ANTI-PVRIG ANTIBODIES AND METHODS OF USE
    Publication number: 20210188974
    Abstract: The present invention is directed to anti-PVRIG antibodies and methods of using same.
    Type: Application
    Filed: June 17, 2020
    Publication date: June 24, 2021
    Inventors: Mark White, Sandeep Kumar, Christopher Chan, Spencer Liang, Lance Stapleton, Andrew W. Drake, Yosi Gozlan, Ilan Vaknin, Shirley Sameah-Greenwald, Liat Dassa, Zohar Tiran, Gad S. Cojocaru, Leonard Presta, Richard Theolis
  • ANTIBODIES DIRECTED TO TIE-2 AND METHODS OF USE
    Publication number: 20210155697
    Abstract: The invention relates to anti-Tie2 antibodies and methods of using the same.
    Type: Application
    Filed: November 19, 2020
    Publication date: May 27, 2021
    Inventors: Jason Damiano, Kristina Oresic Bender, Richard Theolis, Deepika Bhatnagar, Nina Ly
  • ANTI-TIGIT ANTIBODIES, ANTI-PVRIG ANTIBODIES AND COMBINATIONS THEREOF
    Publication number: 20210000952
    Abstract: Anti-PVRIG and anti-TIGIT antibodies are provided.
    Type: Application
    Filed: June 17, 2020
    Publication date: January 7, 2021
    Inventors: Mark White, Sandeep Kumar, Christopher Chan, Spencer Liang, Lance Stapleton, Andrew W. Drake, Yosi Gozlan, Ilan Vaknin, Shirley Sameah-Greenwald, Liat Dassa, Zohar Tiran, Gad S. Cojocaru, Maya Kotturi, Hsin-Yuan Cheng, Kyle Hansen, David Nisim Giladi, Einav Safyon, Eran Ophir, Leonard Presta, Richard Theolis, Radhika Desai, Patrick Wall
  • Anti-TIGIT antibodies, anti-PVRIG antibodies and combinations thereof
    Patent number: 10751415
    Abstract: Anti-PVRIG and anti-TIGIT antibodies are provided.
    Type: Grant
    Filed: August 17, 2017
    Date of Patent: August 25, 2020
    Assignee: Compugen Ltd.
    Inventors: Mark White, Sandeep Kumar, Christopher Chan, Spencer Liang, Lance Stapleton, Andrew W. Drake, Yosi Gozlan, Ilan Vaknin, Shirley Sameah-Greenwald, Liat Dassa, Zohar Tiran, Gad S. Cojocaru, Maya Kotturi, Hsin-Yuan Cheng, Kyle Hansen, David Nisim Giladi, Einav Safyon, Eran Ophir, Leonard Presta, Richard Theolis, Radhika Desai, Patrick Wall
  • ANTI-PVRIG ANTIBODIES AND METHODS OF USE
    Publication number: 20200148769
    Abstract: The present invention is directed to anti-PVRIG antibodies and methods of using same.
    Type: Application
    Filed: January 21, 2020
    Publication date: May 14, 2020
    Inventors: Mark White, Sandeep Kumar, Christopher Chan, Spencer Liang, Lance Stapleton, Andrew W. Drake, Yosi Gozlan, Ilan Vaknin, Shirley Sameah-Greenwald, Liat Dassa, Zohar Tiran, Gad S. Cojocaru, Leonard Presta, Richard Theolis
  • Anti-PVRIG antibodies and methods of use
    Patent number: 10351625
    Abstract: The present invention is directed to anti-PVRIG antibodies and methods of using same.
    Type: Grant
    Filed: February 13, 2018
    Date of Patent: July 16, 2019
    Assignee: Compugen Ltd.
    Inventors: Mark White, Sandeep Kumar, Christopher Chan, Spencer Liang, Lance Stapleton, Andrew W. Drake, Yosi Gozlan, Ilan Vaknin, Shirley Sameah-Greenwald, Liat Dassa, Zohar Tiran, Gad S. Cojocaru, Leonard Presta, Richard Theolis
  • Anti-PVRIG antibodies and methods of use
    Patent number: 10227408
    Abstract: The present invention is directed to anti-PVRIG antibodies and methods of using same.
    Type: Grant
    Filed: February 19, 2016
    Date of Patent: March 12, 2019
    Assignee: Compugen Ltd.
    Inventors: Mark White, Sandeep Kumar, Christopher Chan, Spencer Liang, Lance Stapleton, Andrew W. Drake, Yosi Gozlan, Ilan Vaknin, Shirley Sameah-Greenwald, Liat Dassa, Zohar Tiran, Gad S. Cojocaru, Leonard Presta, Richard Theolis
  • Anti-TIGIT anibodies, anti-PVRIG antibodies and combinations thereof
    Patent number: 10213505
    Abstract: Anti-PVRIG and anti-TIGIT antibodies are provided.
    Type: Grant
    Filed: March 27, 2018
    Date of Patent: February 26, 2019
    Assignee: Compugen Ltd.
    Inventors: Mark White, Sandeep Kumar, Christopher Chan, Spencer Liang, Lance Stapleton, Andrew W. Drake, Yosi Gozlan, Ilan Vaknin, Shirley Sameah-Greenwald, Liat Dassa, Zohar Tiran, Gad S. Cojocaru, Maya Kotturi, Hsin-Yuan Cheng, Kyle Hansen, David Nisim Giladi, Einav Safyon, Eran Ophir, Leonard Presta, Richard Theolis, Radhika Desai, Patrick Wall