Patents by Inventor Richard Thomas Williams
Richard Thomas Williams has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20250032458Abstract: Provided herein are compositions and methods for the treatment of a cancer. Said compositions comprise an FGFR kinase inhibitor. Some embodiments comprise combination therapy featuring the FGFR kinase inhibitor with at least one oncology therapeutic agent.Type: ApplicationFiled: December 7, 2022Publication date: January 30, 2025Inventors: Aleksandra FRANOVIC, Angie VASSAR, Nichol MILLER, Ken KOBAYASHI, Richard Thomas WILLIAMS, John TYHONAS, Robert KANIA, Jason M. COX, Neolito TIMPLE, Eric S. MARTIN, Eric A. MURPHY
-
Publication number: 20240325403Abstract: Provided herein are compositions and methods for the treatment of a cancer. Said compositions comprise a RAF inhibitor. Some embodiments comprise combination therapy featuring the RAF inhibitor with at least one oncology therapeutic agent.Type: ApplicationFiled: January 26, 2024Publication date: October 3, 2024Inventors: Aleksandra FRANOVIC, Eric MARTIN, Nichol L. G. MILLER, Eric MURPHY, Richard Thomas WILLIAMS, Ken KOBAYASHI
-
Patent number: 11918587Abstract: Provided herein are compositions and methods for the treatment of a cancer. Said compositions comprise a RAF inhibitor. Some embodiments comprise combination therapy featuring the RAF inhibitor with at least one oncology therapeutic agent.Type: GrantFiled: April 6, 2023Date of Patent: March 5, 2024Assignee: KINNATE BIOPHARMA INC.Inventors: Aleksandra Franovic, Eric Martin, Nichol L. G. Miller, Eric Murphy, Richard Thomas Williams, Ken Kobayashi
-
Publication number: 20230255977Abstract: Provided herein are compositions and methods for the treatment of a cancer. Said compositions comprise a RAF inhibitor. Some embodiments comprise combination therapy featuring the RAF inhibitor with at least one oncology therapeutic agent.Type: ApplicationFiled: April 6, 2023Publication date: August 17, 2023Inventors: Aleksandra FRANOVIC, Eric MARTIN, Nichol L. G. MILLER, Eric MURPHY, Richard Thomas WILLIAMS, Ken KOBAYASHI
-
Patent number: 10472431Abstract: A metal complex of the formula (1) CyLMZp(A)n (1), wherein M is a group 4 metal Z is an anionic ligand, p is number of 1 to 2, preferably 2, Cy is a cyclopentadienyl-type ligand substituted with at least one aliphatic C3-C20 hydrocarbyl group, which is bonded to the cyclopentadienyl-type ligand, in particular to its cyclopentadienyl ring, via a secondary, a tertiary or quaternary carbon atom and, L is an amidinate ligand of the formula (2), wherein the amidine-containing ligand is covalently bonded to the metal M via the imine nitrogen atom, and Sub1 is a substituent comprising a group 14 atom through which Sub1 is bonded to the imine carbon atom and Sub2 is a substituent comprising a heteroatom of group 15, through which Sub2 is bonded to the imine carbon atom and A is a neutral Lewis base ligand selected from the list consisting of ether, thioether, amine, tertiary phosphane, imine, nitrile and isonitrile, wherein the number of said metal ligands “n” is in the range of 0 to the amount that specifies the 18-Type: GrantFiled: September 8, 2015Date of Patent: November 12, 2019Assignee: ARLANXEO NETHERLANDS B.V.Inventors: Peter Karbaum, Richard Thomas William Scott, John Van De Moosdijk
-
Patent number: 10316113Abstract: A catalyst system comprising a supported catalyst containing a) a solid support, which is a solid methylaluminoxane composition wherein: i) the aluminum content is in the range of 36 to 41 wt % and ii) the mole fraction of methyl groups derived from the trimethylaluminum component relative to the total number of moles of methyl groups is 12 mol % or lower and b) a catalyst thereon which is a metal complex of the formula (1) CyLMZp (1), wherein M is titanium Z is an anionic ligand, p is number of 1 to 2, preferably 2, Cy is a cyclopentadienyl-type ligand and L is an amidinate ligand of the formula (2) wherein the amidine-containing ligand is covalently bonded to the metal M via the imine nitrogen atom, and Sub1 is a substituent comprising a group 14 atom through which Sub1 is bonded to the imine carbon atom and Sub2 is a substituent comprising a heteroatom of group, through which Sub2 is bonded to the imine carbon atom.Type: GrantFiled: August 8, 2016Date of Patent: June 11, 2019Assignee: ARLANXEO NETHERLANDS B.V.Inventors: Alexandra Berthoud, Gerardus Henricus Josephus Van Doremaele, Richard Thomas William Scott, Francisco Perez, Raffaele Bernardo
-
Publication number: 20180237553Abstract: A catalyst system comprising a supported catalyst containing a) a solid support, which is a solid methylaluminoxane composition wherein: i) the aluminum content is in the range of 36 to 41 wt % and ii) the mole fraction of methyl groups derived from the trimethylaluminum component relative to the total number of moles of methyl groups is 12 mol % or lower and b) a catalyst thereon which is a metal complex of the formula (1) CyLMZp (1), wherein M is titanium Z is an anionic ligand, p is number of 1 to 2, preferably 2, Cy is a cyclopentadienyl-type ligand and L is an amidinate ligand of the formula (2) wherein the amidine-containing ligand is covalently bonded to the metal M via the imine nitrogen atom, and Sub1 is a substituent comprising a group 14 atom through which Sub 1 is bonded to the imine carbon atom and Sub2 is a substituent comprising a heteroatom of group, through which Sub2 is bonded to the imine carbon atom.Type: ApplicationFiled: August 8, 2016Publication date: August 23, 2018Applicant: ARLANXEO NETHERLANDS B.V.Inventors: ALEXANDRA BERTHOUD, GERARDUS HENRICUS JOSEPHUSS VAN DOREMAELE, RICHARD THOMAS WILLIAM SCOTT, FRANCISCO PEREZ, RAFFAELE BERNARDO
-
Patent number: 9862736Abstract: The present invention relates to a new bimetallic complex of the formula (1) wherein: M is a group 4-6 metal R1 means is a substituent comprising a heteroatom of group 15, through which R1 is bonded to the imine carbon atom; R2-R6 are the same or different and each represents a hydrogen atom, an optionally substituted C1-10 alkyl group, an optionally substituted C1-10 alkoxy group, an optionally substituted C6-20 aryl group, an optionally substituted C6-20 aryloxy group, an optionally substituted C7-20 aralkyl group, an optionally substituted C7-20 aralkyloxy group, a silyl group substituted with optionally substituted C1-20 hydrocarbon group(s), a C1-20 hydrocarbon-substituted amino group or the adjacent R2-R6 may be linked to each other to form a ring; R7-R10 are the same or different and each represents a hydrogen atom, a halogen atom, an optionally substituted C1-10 alkyl group, an optionally substituted C1-10 alkoxy group, an optionally substituted C6-20 aryl group, an optionally substituted C6-20 aryloxType: GrantFiled: June 18, 2014Date of Patent: January 9, 2018Assignee: ARLANXEO NETHERLANDS B.V.Inventors: Alexandra Berthoud, Victor Quiroga Norambuena, Gerard Van Doremaele, Martin Alexander Zuideveld, Henricus Johannes Arts, Richard Thomas William Scott
-
Patent number: 9815923Abstract: A catalyst system comprising a) a metal complex of the formula CyLMZp, wherein M is a group 4 metal Z is an anionic ligand, p is number of 1 to 2, preferably 2 Cy is a cyclopentadienyl-type ligand and, L is a ligand of the formula wherein each A is independently selected from the group consisting of nitrogen and phosphorus and R1, R2, and R4 are independently selected from the group consisting of hydrogen, unsubstituted or substituted hydrocarbyl, unsubstituted or substituted silyl and unsubstituted or substituted germyl residues, and b) a boron containing activator, characterized in that the molar ratio of the boron of the activator to M of the metal complex is greater than 2.5.Type: GrantFiled: October 7, 2014Date of Patent: November 14, 2017Assignee: ARLANXEO NETERLANDS, B.V.Inventors: Alexandra Berthoud, Victor Quiroga Norambuena, Gerard Van Doremaele, Richard Thomas William Scott
-
Publication number: 20170240663Abstract: A metal complex of the formula (1) CyLMZp(A)n (1), wherein M is a group 4 metal Z is an anionic ligand, p is number of 1 to 2, preferably 2, Cy is a cyclopentadienyl-type ligand substituted with at least one aliphatic C3-C20 hydrocarbyl group, which is bonded to the cyclopentadienyl-type ligand, in particular to its cyclopentadienyl ring, via a secondary, a tertiary or quaternary carbon atom and, L is an amidinate ligand of the formula (2), wherein the amidine-containing ligand is covalently bonded to the metal M via the imine nitrogen atom, and Sub1 is a substituent comprising a group 14 atom through which Sub1 is bonded to the imine carbon atom and Sub2 is a substituent comprising a heteroatom of group 15, through which Sub2 is bonded to the imine carbon atom and A is a neutral Lewis base ligand selected from the list consisting of ether, thioether, amine, tertiary phosphane, imine, nitrile and isonitrile, wherein the number of said metal ligands “n” is in the range of 0 to the amount that specifies the 18-Type: ApplicationFiled: September 8, 2015Publication date: August 24, 2017Applicant: ARLANXEO NETHERLANDS B.V.Inventors: PETER KARBAUM, RICHARD THOMAS WILLIAM SCOTT, JOHN VAN DE MOOSDIJK
-
Patent number: 9624324Abstract: The present invention relates to a new metal complex of the formula (1) wherein: M is a group 4-6 metal R1 means is a substituent comprising a heteroatom of group 15, through which R1 is bonded to the imine carbon atom; R2-R5 are the same or different and each represents a hydrogen atom, an optionally substituted C1-10 alkyl group, an optionally substituted C1-10 alkoxy group, an optionally substituted C6-20 aryl group, an optionally substituted C6-20 aryloxy group, an optionally substituted C7-20 aralkyl group, an optionally substituted C7-20 aralkyloxy group, a silyl group substituted with optionally substituted C1-20 hydrocarbon group(s), a C1-20 hydrocarbon-substituted amino group or the adjacent R2-R5 may be linked to each other to form a ring; R6-R9 are the same or different and each represents a hydrogen atom, a halogen atom, an optionally substituted C1-10 alkyl group, an optionally substituted C1-10 alkoxy group, an optionally substituted C6-20 aryl group, an optionally substituted C6-20 aryloxType: GrantFiled: May 7, 2014Date of Patent: April 18, 2017Assignee: ARLANXEO Netherlands B.V.Inventors: Alexandra Berthoud, Victor Quiroga Norambuena, Gerhard Van Doremaele, Martin Alexander Zuideveld, Philip Mountford, Richard Thomas William Scott
-
Patent number: 9546233Abstract: A metal complex of the formula (1) CyAMX(L)n??(1) wherein Cy is a cyclopentadienyl-type ligand, M is a metal of group 4; A is an amidine-containing ligand moiety, represented by formula 2: wherein the amidine-containing ligand is covalently bonded to the metal M via the imine nitrogen atom, and Sub1 is a substituent comprising a group 14 atom through which Sub1 is bonded to the imine carbon atom and Sub2 is a substituent comprising a heteroatom of group 15, through which Sub2 is bonded to the imine carbon atom; X is an allyl borate ligand derived from a conjugated diene ligand, D, and a borane, B and L is a neutral Lewis basic ligand wherein the number of said metal ligands “n” is in the range of 1 to the amount that specifies the 18-electron rule.Type: GrantFiled: May 7, 2014Date of Patent: January 17, 2017Assignee: ARLANXEO NETHERLANDS B.V.Inventors: Richard Thomas William Scott, Martin Alexander Zuideveld, Philip Mountford
-
Publication number: 20160244543Abstract: A catalyst system comprising a) a metal complex of the formula CyLMZp, wherein M is a group 4 metal Z is an anionic ligand, p is number of 1 to 2, preferably 2 Cy is a cyclopentadienyl-type ligand and, L is a ligand of the formula wherein each A is independently selected from the group consisting of nitrogen and phosphorus and R1, R2, and R4 are independently selected from the group consisting of hydrogen, unsubstituted or substituted hydrocarbyl, unsubstituted or substituted silyl and unsubstituted or substituted germyl residues, and b) a boron containing activator, characterized in that the molar ratio of the boron of the activator to M of the metal complex is greater than 2.5.Type: ApplicationFiled: October 7, 2014Publication date: August 25, 2016Inventors: Alexandra BERTHOUD, Victor QUIROGA NORAMBUENA, Gerard VAN DOREMAELE, Richard Thomas William SCOTT
-
Publication number: 20160122455Abstract: The present invention relates to a new metal complex of the formula (1) wherein: M is a group 4-6 metal R1 means is a substituent comprising a heteroatom of group 15, through which R1 is bonded to the imine carbon atom; R2-R5 are the same or different and each represents a hydrogen atom, an optionally substituted C1-10 alkyl group, an optionally substituted C1-10 alkoxy group, an optionally substituted C6-20 aryl group, an optionally substituted C6-20 aryloxy group, an optionally substituted C7-20 aralkyl group, an optionally substituted C7-20 aralkyloxy group, a silyl group substituted with optionally substituted C1-20 hydrocarbon group(s), a C1-20 hydrocarbon-substituted amino group or the adjacent R2-R5 may be linked to each other to form a ring; R6-R9 are the same or different and each represents a hydrogen atom, a halogen atom, an optionally substituted C1-10 alkyl group, an optionally substituted C1-10 alkoxy group, an optionally substituted C6-20 aryl group, an optionally substituted C6-20 aryloxType: ApplicationFiled: May 7, 2014Publication date: May 5, 2016Applicant: LANXESS Elastomers B.V.Inventors: Alexandra BERTHOUD, Victor QUIROGA NORAMBUENA, Gerhard VAN DOREMAELE, Martin Alexander ZUIDEVELD, Philip MOUNTFORD, Richard Thomas William SCOTT
-
Publication number: 20160122370Abstract: The present invention relates to a new bimetallic complex of the formula (1) wherein: M is a group 4-6 metal R1 means is a substituent comprising a heteroatom of group 15, through which R1 is bonded to the imine carbon atom; R2-R6 are the same or different and each represents a hydrogen atom, an optionally substituted C1-10 alkyl group, an optionally substituted C1-10 alkoxy group, an optionally substituted C6-20 aryl group, an optionally substituted C6-20 aryloxy group, an optionally substituted C7-20 aralkyl group, an optionally substituted C7-20 aralkyloxy group, a silyl group substituted with optionally substituted C1-20 hydrocarbon group(s), a C1-20 hydrocarbon-substituted amino group or the adjacent R2-R6 may be linked to each other to form a ring; R7-R10 are the same or different and each represents a hydrogen atom, a halogen atom, an optionally substituted C1-10 alkyl group, an optionally substituted C1-10 alkoxy group, an optionally substituted C6-20 aryl group, an optionally substituted C6-20 aryloxType: ApplicationFiled: June 18, 2014Publication date: May 5, 2016Inventors: Alexandra BERTHOUD, Victor QUIROGA NORAMBUENA, Gerard VAN DOREMAELE, Martin Alexander ZUIDEVELD, Henricus Johannes ARTS, Richard Thomas William SCOTT
-
Publication number: 20160115265Abstract: A metal complex of the formula (1) CyAMX(L)n??(1) wherein Cy is a cyclopentadienyl-type ligand, M is a metal of group 4; A is an amidine-containing ligand moiety, represented by formula 2: wherein the amidine-containing ligand is covalently bonded to the metal M via the imine nitrogen atom, and Sub1 is a substituent comprising a group 14 atom through which Sub1 is bonded to the imine carbon atom and Sub2 is a substituent comprising a heteroatom of group 15, through which Sub2 is bonded to the imine carbon atom; X is an allyl borate ligand derived from a conjugated diene ligand, D, and a borane, B and L is a neutral Lewis basic ligand wherein the number of said metal ligands “n” is in the range of 1 to the amount that specifies the 18-electron rule.Type: ApplicationFiled: May 7, 2014Publication date: April 28, 2016Inventors: Richard Thomas William SCOTT, Martin Alexander ZUIDEVELD, Philip MOUNTFORD
-
Publication number: 20120287201Abstract: A process for preparing a dispersion of a particulate solid is described, which comprises dispersing a particulate solid with a dispersant and a liquid medium, wherein the dispersant is a random copolymer obtained from the copolymerisation of a composition comprising: i) optionally one or more monoethylenically unsaturated hydrophilic monomers, ii) one or more monoethylenically unsaturated hydrophobic monomers, iii) one or more di- and/or higher-ethylenically unsaturated monomers, and iv) one or more chain transfer agents wherein at least one of the chain transfer agents has one or more hydrophilic anionic groups.Type: ApplicationFiled: November 8, 2010Publication date: November 15, 2012Inventors: Owen Roger Lozman, Richard Thomas Williams
-
Patent number: 8258231Abstract: A process for preparing a dispersion of a particulate solid comprising: dispersing a particulate solid with a dispersant and a liquid medium, wherein the dispersant is a random copolymer obtained or obtainable from the copolymerisation of a composition comprising: i) one or more monoethylenically unsaturated hydrophilic monomers, ii) one or more monoethylenically unsaturated hydrophobic monomers, iii) one or more di- and/or higher-ethylenically unsaturated monomers, and iv) one or more chain transfer agents; wherein the dispersion step is effected by a mechanical treatment which reduces the particle size of the particulate solid.Type: GrantFiled: June 25, 2009Date of Patent: September 4, 2012Assignee: Fujifilm Imaging Colorants LimitedInventors: Owen Roger Lozman, Richard Thomas Williams
-
Publication number: 20110123716Abstract: A process for preparing a dispersion of a particulate solid comprising: dispersing a particulate solid with a dispersant and a liquid medium, wherein the dispersant is a random copolymer obtained or obtainable from the copolymerisation of a composition comprising: i) one or more monoethylenically unsaturated hydrophilic monomers, ii) one or more monoethylenically unsaturated hydrophobic monomers, iii) one or more di- and/or higher-ethylenically unsaturated monomers, and iv) one or more chain transfer agents; wherein the dispersion step is effected by a mechanical treatment which reduces the particle size of the particulate solid.Type: ApplicationFiled: June 25, 2009Publication date: May 26, 2011Inventors: Owen Roger Lozman, Richard Thomas Williams
-
Publication number: 20110040026Abstract: A compound of Formula (1) or a salt thereof: wherein R is H, methyl or ethyl.Type: ApplicationFiled: July 29, 2010Publication date: February 17, 2011Inventors: Owen Roger LOZMAN, Richard Thomas WILLIAMS