Abstract: Provided herein are 3,3-disubstituted 19-nor-steroidal compounds according to Formula (1): and pharmaceutical compositions thereof. Such compounds are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, disorders of memory and/or cognition, movement disorders, personality disorders, autism spectrum disorders, pain,traumatic brain injury, vascular diseases, substance abuse disorders and/or withdrawal syndromes, tinnitus, and status epilepticus.

Abstract: A maintaining member is for a patient interface device. The patient interface device includes a cushion member structured to engage a face of a patient. The maintaining member has body structured to be located on a single side of the face of the patient. The body includes a coupling portion structured to be coupled to the cushion member, and a maintaining portion extending from the coupling portion, the maintaining portion having a receiving portion located opposite and facing the coupling portion, the receiving portion being concave facing in a direction toward the coupling portion in order to maintain the patient interface device on the face of the patient.

Abstract: An additive manufacturing system for printing three-dimensional parts, the system comprising a heatable region, a receiving surface, a print head configured to print a three-dimensional part onto the receiving surface in a layer-by-layer manner along a printing axis, and a drive mechanism configured to index the receiving surface along the printing axis such that the receiving surface and at least a portion of the three-dimensional part out of the heated region.

Abstract: A drilling apparatus, sensor, system and method. The drilling apparatus includes a drill bit and a steering controller that steers the drill bit. The drilling apparatus includes a reluctance sensor system that measures changes in magnetic flux. The reluctance sensor includes two or more magnets creating a bucking effect. The drilling apparatus includes a processor in communication with the reluctance sensor that receives the measurements made by the reluctance sensor to determine a distance or direction to a target object. The distance is utilized by the steering controller to steer the drill bit.

Abstract: Provided herein are 19-nor C3,3-disubstituted steroids of Formula (I): and pharmaceutically acceptable salts thereof; wherein , R1, R2, R3a, R3b, R4a, and R4b are as defined herein, and A is a carbon bound substituted or unsubstituted 5- to 6-membered heteroaryl ring as defined herein. Such compounds are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, convulsive disorders, disorders of memory and/or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and/or withdrawal syndromes, and tinnitus.

Abstract: An electroactive package is disclosed that includes an active film and a pair of transparent conductive layers positioned on opposite sides of the active film. The transparent conductive layers each include an overhang section that extends beyond an edge of the active film, with the overhang sections being located at a periphery of the electroactive package. A bus bar is disclosed that comprises a pair of electrically-conductive layers and an insulative layer positioned between the electrically-conductive layers. The bus bar extends along at least a portion of the periphery of the electroactive package and is positioned between the overhang sections of the transparent conductive layers. Also disclosed are electroactive windows, and methods of making them.

Abstract: A subnasal sealing cushion for a patient interface device includes a cushion member having a front side and a rear side, the rear side being structured to face a face of the user responsive to the patient interface device being donned, the cushion member including: a support portion having an outer wall and a support structure coupled to the outer wall and extending longitudinally along a first direction extending from the front side to the rear side, and a sealing flap portion coupled a nasal shelf portion, the nasal shelf portion defining a nasal orifice and being structured to contact a bottom of a nose of the user to create a seal therewith responsive to the patient interface device being donned by the user, wherein the support structure is positioned under and spaced from a bottom of the nasal shelf portion.

Abstract: A cushion member (2) is for a patient interface device. The cushion member includes a body portion (4) having a first end (6) and a second end (8) disposed opposite the first end, the body portion defining a passage (5) therethrough, and a support portion (10) extending from the second end into the passage. The support portion includes a first portion (12) and a second portion (14) disposed on or in the first portion. The support portion is movable from a first configuration to a second configuration responsive to a change in environment.

Abstract: A bipolar lead acid battery with increased energy density is provided. The battery includes a number of lead acid wafer cell that each comprise a negative electrode having a negative electrode plate and a negative active material positioned on the negative electrode plate, as well as a positive electrode having a positive electrode plate and a positive active material positioned on the positive electrode plate. The positive electrode plate comprises a metal foil with a conductive film thereon, such as a titanium foil or substrate with a titanium silicide coating thereon. The lead acid wafer cell also includes a separator between the negative and positive electrodes, wherein the separator includes an electrolyte for transferring charge between the negative and positive electrodes.

Abstract: Powered patient support apparatuses—such as beds, cots, stretchers, or the like—include a plurality of user controls that allow a caregiver to control the steering and/or driving of one or more powered wheels from multiple different locations around the patient support apparatus (e.g. head end, foot end, and/or the sides). The control is carried out by force sensors that detect both an orientation of the applied forces and a magnitude of the applied forces. Translational and/or rotational movement is effectuated, depending upon the magnitude and direction of the forces, as well as the physical location of the applied force relative to a reference point on the support apparatus, such as the center. One or more object sensors may also be included in the support apparatus to assist in steering and/or navigating.

Abstract: An example slip-ring interface may include a first section and a second section rotationally independent from the first section. At least one conductor path between the first section and the second section may be selectively associated with and dedicated to the transmission of signals with a first signal type. At least one conductor path between the first section and the second section may be selectively associated with and dedicated to the transmission of signals with a second signal type. If error conditions occur, the signal types associated with one or more of the conductor paths may be changed so that signals of both the first and second signal types are transmitted across the interface.

Abstract: A cooling device includes a package substrate, a plurality of cooling units, and device electronics. The plurality of cooling units are configured to cool a user's body. Each cooling unit includes a plurality of semiconductor cooling elements sandwiched between a first cooling unit substrate and a second cooling unit substrate. Each of the cooling units is connected to the package substrate. The device electronics are coupled to the cooling units. The device electronics are configured to store a first cooling device profile that includes data indicating an amount of power to deliver to each of the cooling units over a period of time. The device electronics are configured to deliver power to the cooling units according to the first cooling device profile, wirelessly receive a second cooling device profile from an external computing device, and deliver power to the cooling units according to the second cooling device profile.

Abstract: A patient interface device includes a sealing cushion, and a tubing assembly structured to receive a breathing gas from a pressure generating device. The tubing assembly has: (i) a first chamber fluidly coupled to the sealing cushion, the first chamber being structured to deliver a flow of the breathing gas to the sealing cushion, and (ii) a second chamber having a pressure sensing module disposed therein, the second chamber having a closed end and an open end, the open end being fluidly coupled to the sealing cushion such that the second chamber is structured to carry only a positive pressure and substantially zero gas flow.

Abstract: The present invention relates to compositions comprising a silicate and methods of use thereof. In particular, the compositions of the present invention are suitable for treating inflammatory conditions, cancer, bacterial and viral infections, and infected and uninfected wounds. The compositions of the present invention can also be useful in treating spinal cord injury, tissue remodeling, and promoting bone growth and repair.

Abstract: A mobile terminal in a wireless communications system estimates channel characteristics from transmissions of a base station comprising reference symbols arranged in a first density and distribution. In the event of an impairment in accuracy of channel estimation, the mobile terminal first applies a checking function to determine whether a base station identity conflict is present. If such a conflict is detected, it transmits a report to the base station to initiate a network channel reallocation process to remove the conflict. If no conflict is detected, the base station is instructed to initiate a function to change the density and distribution of the reference symbols. This allows a dynamic system to distinguish between different causes of poor channel quality, allowing adaptation of the transmissions of the base stations in a manner appropriate to the cause identified.

Abstract: The present invention provides a method for determining thromboembolic risk in a patient. The method includes processing functional images of a patient's heart in order to create a computational fluid dynamic (CFD) modeling of the patient's heart. Once a CFD model is obtained, various metrics can be determined to estimate the patient's risk of left ventricular thrombosis. This method is particularly suited for determining thromboembolic risk in patients having suffered a myocardial infarction. However, the method can also be applied to a broader population at risk of cardioembolic and cryptogenic stroke.