Abstract: Disclosed herein are methods for using therapeutic compounds, for example BH3 mimetics such as MCL1 inhibitors, to treat patients that may have failed to respond to targeted or immunotherapy treatments. In several embodiments, methods for treating such patients include combining MCL1 inhibitors with immunotherapies to enhance immunotherapy treatment. For example, the combination of MCL1 inhibitors with immunotherapies is used to treat cancer, such as melanoma. In some embodiments, MCL1 inhibitory compounds and therapies may be useful in treating tissues or tumors having one or more MDSC cell expressing high levels of MCL1. In some embodiments, MCL1 and BCL2 inhibitory compounds and therapies comprising same may be used to treat one or more melanomas, for example cutaneous melanoma, melanoma subtypes selected from uveal, acral, and mucosal. In some embodiments, MCL1 inhibitory compounds and therapies comprising same may be used to treat one or more melanomas, for example uveal melanoma.

Abstract: The invention relates to methods for treating cancers by targeting the elimination of selective activated immune cell populations in combination with checkpoint inhibitors. The cells may be targeted, for instance, using CLIP inhibitors and or MHC class II inducers.

Abstract: The invention relates to methods for treating cancers by targeting the elimination of selective activated immune cell populations in combination with checkpoint inhibitors. The cells may be targeted, for instance, using CLIP inhibitors and or MHC class II inducers.

Abstract: The disclosure relates to methods for treating disorders of the mucosal tract such as the gastrointestinal system by targeting CLIP molecules. The methods are based on that CLIP in the groove of MHC class I or II molecules of the cells lining the mucosal surfaces of the body, such as the gastrointestinal tract, provides protection from MHC Class II or MHC class I mediated cell death, and therefore are useful for treating, inhibiting the development of a multitude of illnesses and conditions of the mucosal tract, including autoimmune disease.

Abstract: The invention relates to methods and related products for preventing and treating disease, based on the use of plant viral vaccines and plant viral defense strategies. The methods also involve the identification of appropriate therapeutic strategies for diseases such as cancers.

Abstract: The invention relates to methods for treating disorders by targeting CLIP molecules and MHC. The methods are useful for treating, inhibiting the development of, or otherwise dealing with diseases such as HIV, blood vessel proliferative disorder, cancer and fibrosis.

Abstract: The disclosure relates to methods for treating disorders of the mucosal tract such as the gastrointestinal system by targeting CLIP molecules. The methods are based on that CLIP in the groove of MHC class I or II molecules of the cells lining the mucosal surfaces of the body, such as the gastrointestinal tract, provides protection from MHC Class II or MHC class I mediated cell death, and therefore are useful for treating, inhibiting the development of a multitude of illnesses and conditions of the mucosal tract, including autoimmune disease.

Abstract: The invention relates to methods and products for producing fatty acids by manipulating metabolic function in plants and fungus. The fatty acids generated according to the invention may be useful in the production of biofuels.

Abstract: The invention relates to methods and products for producing fatty acids by manipulating metabolic function in plants and fungus. The fatty acids generated according to the invention may be useful in the production of biofuels.

Abstract: The invention relates to methods and products for producing fatty acids by manipulating metabolic function in plants and fungus. The fatty acids generated according to the invention may be useful in the production of biofuels.

Abstract: A foot spa and a method for controlling the foot spa is provided. The foot spa has a housing defining a reservoir for retaining a volume of fluid, and a lid selectively covering a portion of the reservoir. The foot spa can have any combination of a remote control unit for generating a signal for controlling a plurality of functions of the foot spa, a receiver for receiving the control signal, a retractable cord, an infrared heater, an in-line fluid heater, adjustable fluid jets, a spinning massage attachment function, and a control assembly operable by the foot of the user.

Abstract: By incorporating ceramic materials to produce far-infrared and/or infrared radiation and impart the radiation into the heated air stream for delivery directly to the hair fibers, a hair dryer is realized which is capable of providing enhanced beneficial effects to the hair fibers in a cost effective manner. In accordance with the present invention, ceramic components or ceramic coated components are mounted in association with the heating means and/or the exit portal for delivering the desired infrared/far-infrared radiation directly to the airflow exiting the hair dryer, for delivery to the hair fibers. In one embodiment, a ceramic coated member is mounted adjacent the exit portal, positioned for enabling the heated airflow to contact the ceramic coated member and generate and/or emit far-infrared/infrared radiation, while several alternate embodiment mount the ceramic material directly with the heating member.