Abstract: Several embodiments disclosed herein pertain to polymer compositions with optical enhancing agents. In some embodiments, the compositions are provided as polymer (layers including medical films), devices, or parts of devices. Some embodiments provide methods of making such compositions and articles of manufacture comprising them, as well as methods of using polymer compositions or the articles made therefrom. In several embodiments, the polymer formulation includes a base polymer and an optical enhancing additive. In some embodiments, surprisingly, the optical enhancing additive confers upon the polymer film improved stability, including thermal stability.