Patents by Inventor Richard Varsolona

Richard Varsolona has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystalline forms of 5,11-dihydro-11-ethyl-5-methyl-8-{2-{(1-oxido-4-quinolinyl)oxy}ethyl}-6H-dipyrido[3,2-b:2?,3?-e] [1,4]diazepin-6-one
    Patent number: 7309700
    Abstract: Dihydrate and anhydrous crystalline forms of 5,11-dihydro-11-ethyl-5-methyl-8-{2-{(1-oxido-4-quinolinyl)oxy}ethyl}-6H-dipyrido[3,2-b:2?,3?-e] [1,4]diazepin-6-one.
    Type: Grant
    Filed: March 18, 2005
    Date of Patent: December 18, 2007
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Carl A. Busacca, Michael Cerreta, Richard Varsolona, John Smoliga, Jon Lorenz, Jana Vitous
  • Synthesis of 6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonic acid amides
    Publication number: 20060025447
    Abstract: Disclosed is a multi-step process for preparing a compound of Formula I: wherein R1 to R3 are as defined herein. The compounds of formula I inhibit the binding of human intercellular adhesion molecules to the Leukointegrins. As a result, these compounds are useful in the treatment of inflammatory and immune cell-mediated diseases.
    Type: Application
    Filed: July 25, 2005
    Publication date: February 2, 2006
    Applicants: Boehringer Ingelheim Pharmaceuticals, Inc., Boehringer Ingelheim International GmbH
    Inventors: Xiao-Jun Wang, Thomas Wirth, Thomas Nicola, Li Zhang, Rogelio Frutos, Yibo Xu, Dhileopkumar Krishnamurihy, Laurence Nummy, Richard Varsolona, Chris Senanayake, Jutta Kroeber
  • Crystalline forms of 5, 11-dihydro-11-ethyl-5-methyl-8-{2-{(1-oxido-4-quinolinyl)oxy}ethyl}-6H-dipyrido[3,2-b:2',3'-e] [1,4]diazepin-6-one
    Publication number: 20050222134
    Abstract: Dihydrate and anhydrous crystalline forms of 5,11-dihydro-11-ethyl-5-methyl-8-{2-{(1-oxido-4-quinolinyl)oxy}ethyl}-6H-dipyrido[3,2-b:2?,3?-e] [1,4]diazepin-6-one.
    Type: Application
    Filed: March 18, 2005
    Publication date: October 6, 2005
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Carl Busacca, Michael Cerreta, Richard Varsolona, John Smoliga, Jon Lorenz, Jana Vitous
  • Dihydroxy open-acid salt of simvastatin
    Publication number: 20050119343
    Abstract: The instant invention provides methods and pharmaceutical compositions for inhibiting HMG-CoA reductase, as well as for treating and/or reducing the risk for diseases and conditions affected by inhibition of HMG-CoA reductase, comprising orally administering a therapeutically effective amount of a crystalline hydrated form of the calcium salt of dihydroxy open acid simvastatin to a patient in need of such treatment. Methods for making the calcium salt of dihydroxy open acid simvastatin are also provided.
    Type: Application
    Filed: November 5, 2004
    Publication date: June 2, 2005
    Inventors: Richard Tillyer, Paul Reider, Edward Grabowski, Feng Xu, Robert Wenslow, Jose Vega, Richard Varsolona