Abstract: Tissue access devices and methods of using the same are disclosed. The devices can have a sensor configured to occlude a flow path by deflecting a membrane into the flow path when the devices become dislodged from tissue. The sensor can be configured to partially or fully occlude the flow path. The sensor can have a spring. The spring can be biased to move the sensor from a sensor first configuration to a sensor second configuration when a force applied by the sensor first surface against a non-sensor surface changes from a first force to a second force less than the first force. The membrane can be deflected into the flow path when the sensor is in the sensor second configuration.

Abstract: Tissue access devices and methods of using and making the same are disclosed. The devices can have a sensor configured to occlude a flow path by deflecting a membrane into the flow path when the devices become dislodged from tissue. The sensor can be configured to partially or fully occlude the flow path. The sensor can have a spring, can be a spring, or may not have a spring. The sensor can be static or can be moved from a sensor first configuration to a sensor second configuration. The membrane can be deflected into the flow path when the sensor is in the sensor second configuration.

Abstract: Systems and methods relate to targeted display of media content, including a system that includes at least one processor configured to execute program instructions to implement a device and a content management system (CMS) and control the system to: send, by the device and to the CMS, a plurality of signals each triggering the CMS to play on a first display that is local to and separate from the device, a respective one of a plurality of media content of a playlist including a first media content, each of the plurality of signals sent at a different time while the first media content of the playlist is played on the first display, and ignore, by the CMS, each of the plurality of signals received prior to a first predetermined time of the played first media content of the playlist.

Abstract: Systems and methods relate to targeted display of media content, including a device that includes a memory having program instructions stored therein; and at least one processor configured to execute the program instructions to control the device to: connect via a wide area network to a remote system, receive a rule set or an artificial intelligence (AI) model from the remote system, select media content from a plurality of media content based on applying demographics data to the rule set or AI model, and cause, based on an output of the rule set or AI model, a display, that is local to the device, to display the media content.

Abstract: Systems and methods relate to display of insights, including a method including: causing a user display to display a graphical user interface (GUI) that enables a user to select a time range and a single digital display as a locale; and causing, based on the user selecting the time range and the single digital display as the locale, the user display to display, on the GUI, a list of a plurality of media content that have been displayed on the single digital display, each of the plurality of media content being ordered according to analysis insight for the single digital display selected and the time range selected. The analysis insight may include at least opportunity to see (OTS) counts of the plurality of media content on one or more digital displays associated with the locale.

Abstract: Systems and methods relate to display of insights, including a method including: causing a user display to display a graphical user interface (GUI) that enables a user to select a time range and a single digital display as a locale; and causing, based on the user selecting the time range and the single digital display as the locale, the user display to display, on the GUI, a list of a plurality of media content that have been displayed on the single digital display, each of the plurality of media content being ordered according to analysis insight for the single digital display selected and the time range selected. The analysis insight may include at least impression counts that are counts of views by people of the plurality of media content on one or more digital displays associated with the locale.

Abstract: Systems and methods relate to display of insights, including a method including: causing a user display to display a graphical user interface (GUI) that enables a user to select a time range and a single digital display as a locale; and causing, based on the user selecting the time range and the single digital display as the locale, the user display to display, on the GUI, a list of a plurality of media content that have been displayed on the single digital display, each of the plurality of media content being ordered according to analysis insight for the single digital display selected and the time range selected. The analysis insight may include at least impression counts that are counts of views by people of the plurality of media content on one or more digital displays associated with the locale.

Abstract: Systems and methods relate to display of insights, including a system including a remote computing system configured to cause a user display to display a graphical user interface (GUI), wherein the GUI enables a user to select a time range and a locale, the GUI displays a list of a plurality of media content that have been displayed on one or more digital displays associated with the locale, each of the plurality of media content being listed according to impression counts of each of the plurality of media content for the locale selected and the time range selected, and each of the impression counts is a count of views by people of a respective media content of the plurality media content on the one or more digital displays of the locale.

Abstract: Systems and methods relate to targeted display of media content, including a device that includes a memory having program instructions stored therein; and at least one processor configured to execute the program instructions to control the device to: connect via a wide area network to a remote system, receive a rule set or an artificial intelligence (AI) model from the remote system, select media content from a plurality of media content based on applying demographics data to the rule set or AI model, and cause, based on an output of the rule set or AI model, a display, that is local to the device, to display the media content.

Abstract: Systems and methods relate to display of insights, including a system including a remote computing system configured to cause a user display to display a graphical user interface (GUI), wherein the GUI enables a user to select a time range and a locale, the GUI displays a list of a plurality of media content that have been displayed on one or more digital displays associated with the locale, each of the plurality of media content being listed according to impression counts of each of the plurality of media content for the locale selected and the time range selected, and each of the impression counts is a count of views by people of a respective media content of the plurality media content on the one or more digital displays of the locale.

Abstract: Human TBK genes are identified as modulators of the beta catenin pathway, and thus are therapeutic targets for disorders associated with defective beta catenin function. Methods for identifying modulators of beta catenin, comprising screening for agents that modulate the activity of TTBK are provided.

Abstract: Human TKT genes are identified as modulators of the beta-catenin pathway, and thus are therapeutic targets for disorders associated with defective beta-catenin function. Methods for identifying modulators of beta-catenin, comprising screening for agents that modulate the activity of TKT are provided.

Abstract: Human UP genes are identified as modulators of the beta catenin pathway, and thus are therapeutic targets for disorders associated with defective beta catenin function. Methods for identifying modulators of beta catenin, comprising screening for agents that modulate the activity of UP are provided.