Abstract: A drilling machine is provided for breaking chips formed by drilling action into manageable lengths. The drilling machine comprises a first gear having a first axis of rotation, and a cam follower surface. It has a second gear having a second axis of rotation coincident with the first axis of rotation. A housing is provided configured to support the first gear and the second gear, the housing having an undulating cam plate surface, a spring and a tool holder spindle having a third axis of rotation. The first and second gears are configured to impart both a linear feed and a rotation to the spindle. The first and second axes of rotation are coincident with the third axis of rotation such that the cam surface is urged into contact with the cam follower surface by the spring. The cam surface includes a plurality of steel balls positioned to follow the cam plate surface such that when the first gear rotates, the first gear is caused repeatedly to retract and then to advance, breaking chips that are formed.

Abstract: A drilling machine is provided for breaking chips formed by drilling action into manageable lengths. The drilling machine comprises a first gear having a first axis of rotation, and a cam follower surface. It has a second gear having a second axis of rotation coincident with the first axis of rotation. A housing is provided configured to support the first gear and the second gear, the housing having a cam surface, a spring and a tool holder spindle having a third axis of rotation. The first and second gears are configured to impart both a linear feed and a rotation to the spindle. The first and second axes of rotation are coincident with the third axis of rotation such that the cam surface is urged into contact with the cam follower surface by the spring. The cam surface and the follower surface are shaped such that when the first gear rotates, the first gear is caused repeatedly to retract and then to advance, breaking chips that are formed.

Abstract: A drilling machine is provided for breaking chips formed by drilling action into manageable lengths. The drilling machine comprises a first gear having a first axis of rotation, and a cam follower surface. It has a second gear having a second axis of rotation coincident with the first axis of rotation. A housing is provided configured to support the first gear and the second gear, the housing having a cam surface, a spring and a tool holder spindle having a third axis of rotation. The first and second gears are configured to impart both a linear feed and a rotation to the spindle. The first and second axes of rotation are coincident with the third axis of rotation such that the cam surface is urged into contact with the cam follower surface by the spring. The cam surface and the follower surface are shaped such that when the first gear rotates, the first gear is caused repeatedly to retract and then to advance, breaking chips that are formed.

Abstract: A drilling machine is provided for breaking chips formed by drilling action into manageable lengths. The drilling machine comprises a first gear having a first axis of rotation, and a cam follower surface. It has a second gear having a second axis of rotation coincident with the first axis of rotation. A housing is provided configured to support the first gear and the second gear, the housing having an undulating cam plate surface, a spring and a tool holder spindle having a third axis of rotation. The first and second gears are configured to impart both a linear feed and a rotation to the spindle. The first and second axes of rotation are coincident with the third axis of rotation such that the cam surface is urged into contact with the cam follower surface by the spring. The cam surface includes a plurality of steel balls positioned to follow the cam plate surface such that when the first gear rotates, the first gear is caused repeatedly to retract and then to advance, breaking chips that are formed.

Abstract: A drilling machine is provided for breaking chips formed by drilling action into manageable lengths. The drilling machine comprises a first gear having a first axis of rotation, and a cam follower surface. It has a second gear having a second axis of rotation coincident with the first axis of rotation. A housing is provided configured to support the first gear and the second gear, the housing having a cam surface, a spring and a tool holder spindle having a third axis of rotation. The first and second gears are configured to impart both a linear feed and a rotation to the spindle. The first and second axes of rotation are coincident with the third axis of rotation such that the cam surface is urged into contact with the cam follower surface by the spring. The cam surface and the follower surface are shaped such that when the first gear rotates, the first gear is caused repeatedly to retract and then to advance, breaking chips that are formed.

Abstract: A pneumatic drilling machine is provided, comprising a pneumatic motor, a circuit for connecting the motor to a source of compressed air, a tool holder spindle, and a drive mechanism. The drive mechanism comprises a coupling shaft which can be moved to select a first mode of driving the spindle and a second method of driving the spindle. The mechanism has a driving cycle which comprises a stationary mode at the beginning and end of the cycle, and at least one phase for driving the spindle according to the first driving method, then a phase for driving the spindle according to the second driving method, then the stopping of the supply of air to the motor. A supply valve of the circuit is controlled pneumatically by the drive mechanism to interrupt the supply of compressed air to the motor at the end of the driving cycle.

Abstract: A drilling machine is provided for breaking chips formed by drilling action into manageable lengths. The drilling machine comprises a first gear having a first axis of rotation, and a cam follower surface. It has a second gear having a second axis of rotation coincident with the first axis of rotation. A housing is provided configured to support the first gear and the second gear, the housing having a cam surface, a spring and a tool holder spindle having a third axis of rotation. The first and second gears are configured to impart both a linear feed and a rotation to the spindle. The first and second axes of rotation are coincident with the third axis of rotation such that the cam surface is urged into contact with the cam follower surface by the spring. The cam surface and the follower surface are shaped such that when the first gear rotates, the first gear is caused repeatedly to retract and then to advance, breaking chips that are formed.

Abstract: A pneumatic drilling machine is provided, comprising a pneumatic motor, a circuit for connecting the motor to a source of compressed air, a tool holder spindle, and a drive mechanism. The drive mechanism comprises a coupling shaft which can be moved to select a first mode of driving the spindle and a second method of driving the spindle. The mechanism has a driving cycle which comprises a stationary mode at the beginning and end of the cycle, and at least one phase for driving the spindle according to the first driving method, then a phase for driving the spindle according to the second driving method, then the stopping of the supply of air to the motor. A supply valve of the circuit is controlled pneumatically by the drive mechanism to interrupt the supply of compressed air to the motor at the end of the driving cycle.

Abstract: A pneumatic drilling machine is provided, comprising a pneumatic motor, a circuit for connecting the motor to a source of compressed air, a tool holder spindle, and a drive mechanism. The drive mechanism comprises a coupling shaft which can be moved to select a first mode of driving the spindle and a second method of driving the spindle. The mechanism has a driving cycle which comprises a stationary mode at the beginning and end of the cycle, and at least one phase for driving the spindle according to the first driving method, then a phase for driving the spindle according to the second driving method, then the stopping of the supply of air to the motor. A supply valve of the circuit is controlled pneumatically by the drive mechanism to interrupt the supply of compressed air to the motor at the end of the driving cycle.

Abstract: A pneumatic drilling machine is provided, comprising a pneumatic motor, a circuit for connecting the motor to a source of compressed air, a tool holder spindle, and a drive mechanism. The drive mechanism comprises a coupling shaft which can be moved to select a first mode of driving the spindle and a second method of driving the spindle. The mechanism has a driving cycle which comprises a stationary mode at the beginning and end of the cycle, and at least one phase for driving the spindle according to the first driving method, then a phase for driving the spindle according to the second driving method, then the stopping of the supply of air to the motor. A supply valve of the circuit is controlled pneumatically by the drive mechanism to interrupt the supply of compressed air to the motor at the end of the driving cycle.

Abstract: A method of treatment of: i) HIV-1 infections in mammals, including humans; or ii) HBV infections in mammals, including humans; which method comprises the administration to the human in need of such treatment, an effective amount of the (R)-enantiomer of the triphosphate of a compound of formula (A) or a pharmaceutically acceptable salt thereof; and compounds for use in the method.