Abstract: A fastening assembly for fastening a beam blocker to an extraction plate, the fastening assembly including a mounting pin having a shaft portion, a base portion at a first end of the shaft portion, and a head portion at a second end of the shaft portion, a centering sleeve radially surrounding the shaft portion and axially abutting the base portion, the centering sleeve being radially compressible between the shaft portion and the extraction plate and between the shaft portion and the beam blocker, an annular spacer surrounding the centering sleeve and axially abutting the beam blocker, with the centering sleeve extending partially into the spacer, and a latching cap surrounding the shaft portion and axially abutting the spacer, with the shaft portion extending through a through hole of the latching cap, the through hole being smaller than the head portion in a direction perpendicular to an axis of mounting pin.

Abstract: The present disclosure relates to a method for the treatment or prevention of atrial fibrillation and/or atrial flutter comprising coadministration of a therapeutically effective amount of ivabradine or a pharmaceutically acceptable salt thereof and a therapeutically effective amount of ranolazine. Also provided are methods for modulating ventricular and atrial rate. This disclosure also relates to pharmaceutical formulations that are suitable for such combined administration.

Abstract: Exercise-induced T-wave alternans (TWA) in coronary artery disease patients reflects significant levels of spatial heterogeneity of repolarization, which may underlie the predictive utility of TWA in estimating risk of sudden cardiac death. A method for assessing spatial heterogeneity of repolarization of a heart of a patient includes the following steps: simultaneously sensing an ECG signal from each of a plurality of spatially separated leads attached to the patient; for a plurality of N beats in each of the ECG signals, identifying a JT interval of each beat; and for corresponding ones of the JT intervals of the ECG signals, calculating a second central moment indicative of spatial heterogeneity of repolarization.