Patents by Inventor Richard Wa Luke

Richard Wa Luke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Piperizine-4-phenyl derivatives as inhibitors of the interaction between mdm2 and p 53
    Patent number: 6770627
    Abstract: A compound of formula (1), wherein: R5 is hydrogen, C1-4alkyl, R6CH2— or R6C(O)—; R6 is aryl, heteroaryl, heterocyclyl, aminoC3-6alkyl, N-(C1-4alkyl)aminoC3-6alkyl, NN-(diC1-4alkyl)aminoC3-6alkyl, or R7; wherein the aryl, heteroaryl or heterocyclyl rings may be optionally substituted with up to three substituents independently selected from nitro, C1-4alkyl, C1-4alkoxy, halo, (C1-4alkyl)sulfanyl, C1-4alkoxycarbonyl, N-(C1-4alkyl)carbamoyl, NN-(diC1-4alkyl)carbamoyl, N-(C1-4alkyl)amino or NN-(diC1-4alkyl)amino; wherein R7 is either a group or formula (2) or formula (3); and wherein L1, L2, L3, L4, R1, R2, R3, R4, R8, R9, R10, R11, R12, R13, A1, n, p, q, r and s are as defined herein. The compounds of formula (1) inhibit the interactions between MDM2 and p53 and may be useful in the treatment of cancers.
    Type: Grant
    Filed: March 7, 2001
    Date of Patent: August 3, 2004
    Assignee: AstraZeneca AB
    Inventors: Richard Wa Luke, Philip J. Jewsbury, Ronald Cotton