Abstract: Embodiments herein provide a mandibular positioning appliance that is fully adjustable (adjustable in all planes). The appliance may be used for the management of sleep disordered breathing (SDB). The full spectrum of SDB, from the mildest snoring to severe obstructive sleep apnea (OSA), may be managed by the stabilization and features that this appliance offers. In embodiments, an appliance may be used by itself or may be used in conjunction with other therapies, such as positive airway pressure and/or a tongue retaining device.

Abstract: A unitary plural-material, interocclusal dental appliance is disclosed for use in connection with orthodontic/orthopedic treatment of the teeth and jaws of a patient's mouth. The appliance includes a first region made from a first material that provides a relatively hard expanse with first and second surfaces, and with the second surface being contactable by one such set of teeth. The second surface may be constructed with a substantially planar shape, or with a shape conforming generally to the cusps of such one set of teeth. A second region is joined to the first region, and is made from a second material that provides a relatively soft, persistently resilient enclosure for the other such set of teeth. The second region includes plural zones, each of which is structured to allow an adjacent enclosed tooth to move toward the first surface of the first region, with such movement resulting in penetration of corresponding teeth into the relatively hard first material for a relatively precise distance.

Abstract: A unitary plural-material, interocclusal dental appliance is disclosed for use in connection with orthodontic/orthopedic treatment of the teeth and jaws of a patient's mouth. The appliance includes a first region made from a first material that provides a relatively hard expanse with first and second surfaces, and with the second surface being contactable by one such set of teeth. The second surface may be constructed with a substantially planar shape, or with a shape conforming generally to the cusps of such one set of teeth. A second region is joined to the first region, and is made from a second material that provides a relatively soft, persistently resilient enclosure for the other such set of teeth. The second region includes plural zones, each of which is structured to allow an adjacent enclosed tooth to move toward the first surface of the first region, with such movement resulting in penetration of corresponding teeth into the relatively hard first material for a relatively precise distance.

Abstract: Compounds of the formula (I): ##STR1## wherein: n is 3 to 5;Y is --CH.sub.2 --CH.sub.2 or --CH.dbd.CH-- or --C.tbd.C--R.sub.1 is C.sub.1-4 alkyl;R.sub.2 is hydrogen, C.sub.1-4 alkyl or phenyl;R.sub.3 is hydroxy or protected hydroxy;R.sub.4 is hydrogen, C.sub.1-9 alkyl, C.sub.3-8 cycloalkyl, phenyl, naphthyl, any of which phenyl moieties or naphthyl moieties may be substituted by one or more halogen, trifluoromethyl, C.sub.1-6 alkyl, hydroxy, C.sub.1-6 alkoxy, phenyl C.sub.1-6 alkoxy or nitro groups; andR.sub.5 is C.sub.1-6 alkyl having useful pharmacological activity, compositions containing them and processes for their preparation.

Abstract: Compounds of the formula 1: ##STR1## wherein: X is O or S;R.sub.1 is hydrogen, or CO.sub.2 R.sub.1 represents an ester group in which the R.sub.1 moiety contains from 1-12 carbon atoms;R.sub.2 is hydrogen or C.sub.1-4 alkyl;R.sub.4 is C.sub.1-9 alkyl, C.sub.3-8 cycloalkyl or C.sub.3-8 cycloalkyl-C.sub.1-6 alkyl; orR.sub.2 and R.sub.4 taken with the carbon atom to which they are joined represent a C.sub.5-8 cycloalkyl group; andR.sub.5 is C.sub.1-6 alkyl; and salts thereof, having similar activity to natural prostaglandins, a process for their preparation, intermediates useful in that process and pharmaceutical compositions containing them.

Abstract: A compound of the formula (I): ##STR1## wherein: X is O or S;Y is --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH-- or --C.tbd.C--;n is 1 to 5;R.sub.1 is hydrogen or CO.sub.2 R.sub.1 represents an ester group in which the R.sub.1 moiety contains from 1 to 12 carbon atoms;R.sub.2 is hydrogen or C.sub.1-4 alkyl;R.sub.3 is hydroxy or protected hydroxy;R.sub.4 is C.sub.1-9 alkyl, C.sub.3-8 cycloalkyl or C.sub.3-8 cycloalkyl-C.sub.1-6 alkyl; orR.sub.2 and R.sub.4 taken with the carbon atom to which they are joined represent a C.sub.5-8 cycloalkyl group; andR.sub.5 is (CH.sub.2).sub.a NR.sub.6 R.sub.7, wherein a is 0 to 3 and R.sub.6 and R.sub.7 are hydrogen, C.sub.1-4 alkyl or phenyl C.sub.1-4 alkyl, or R.sub.6 and R.sub.7 taken with the nitrogen atom to which they are joined represent a 4 to 7 membered heterocyclic ring which may contain as sole further hetero atom one oxygen atom or one optionally C.sub.1-4 alkyl substituted nitrogen atom; allyl or propargyl; (CH.sub.2).sub.b --CO--(CH.sub.2).sub.c --CH.sub.

Abstract: A compound of formula (I): ##STR1## wherein: M IS 0 OR 1;N is 4 to 8;A is hydrogen, and when m is 0 and R.sub.5 is methyl it may also be methyl or a group CO.sub.2 B wherein B is hydrogen or CO.sub.2 B represents an ester group in which the B moiety contains from 1 to 12 carbon atoms;X is CO, protected CO, CROH in which R is hydrogen or C.sub.1-4 alkyl and in which the OH moiety may be protected; R.sub.1 is hydrogen, or CO.sub.2 R.sub.1 represents an ester group in which the R.sub.1 moiety contains 1 to 12 carbon atoms;R.sub.4 is hydrogen, C.sub.1-9 alkyl, C.sub.5-8 cycloalkyl, C.sub.5-8 cycloalkyl-C.sub.1-6 alkyl, phenyl, phenyl C.sub.1-6 alkyl, naphthyl, naphthyl C.sub.1-6 alkyl, any of which phenyl or naphthyl moieties may be substituted by one or more halogen, trifluoromethyl, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, or nitro groups;D is a group --CH.sub.2 --CH(R.sub.6)--CH(R.sub.7)--C(R.sub.2)(R.sub.3)--, a group--CH.sub.2 --CH(R.sub.6)--CH(R.sub.7)--CH(R.sub.8)--C(R.sub.2)(R.sub.3)--, a group--CH.sub.