Abstract: A system for infusing liquid resin into a sheet of fibrous material comprises a tool and a permeable media layer, configured to have the sheet therebetween. The system further comprises a non-permeable bladder, configured to be sealed to the tool about the sheet of fibrous material and the permeable media layer such that the sheet of fibrous material and the permeable media layer are sealed between the non-permeable bladder and the tool. The system additionally comprises an inlet, selectively fluidically coupleable with the permeable media layer to deliver liquid resin to the permeable media layer. The system also comprises an outlet, selectively fluidically coupleable with the permeable media layer to create a pressure differential across the non-permeable bladder. The system further comprises a permeability control valve, selectively operable to adjust the permeability of the permeable media layer.

Abstract: Presented herein are novel peptides and peptide agents for diagnosing, preventing or treating Huntingtin's Disease.

Abstract: The disclosure provides synthetic peptides that selectively bind to the PD-L1 protein on the surface of cells expressing PD-L1. The PD-L1 binding peptide may comprises the amino acid sequence MX1X2X3X4DHX5LNKFX6IX7HX8X9X10X11X12X13 (SEQ ID NO: 177) or MXIF?XXIXXX?WXLXXA (SEQ ID NO: 1). Peptides of the disclosure may be functionalized using one or more diagnostic agents to aid in various detection modalities or with a cytotoxic agent to treat various disease states such as cancer. Also provided are compositions that include the PD-L1 binding peptides or functionalized PD-L1 binding peptides.

Abstract: A system for infusing liquid resin into a sheet of fibrous material comprises a tool and a permeable media layer, configured to have the sheet therebetween. The system further comprises a non-permeable bladder, configured to be sealed to the tool about the sheet of fibrous material and the permeable media layer such that the sheet of fibrous material and the permeable media layer are sealed between the non-permeable bladder and the tool. The system additionally comprises an inlet, selectively fluidically coupleable with the permeable media layer to deliver liquid resin to the permeable media layer. The system also comprises an outlet, selectively fluidically coupleable with the permeable media layer to create a pressure differential across the non-permeable bladder. The system further comprises a permeability control valve, selectively operable to adjust the permeability of the permeable media layer.

Abstract: A method of infusing liquid resin into a sheet of fibrous material comprises evacuating gaseous contaminants from the sheet of fibrous material through a permeable media layer to an outlet and comprises flowing liquid resin from an inlet through the permeable media layer. The method further comprises infusing the liquid resin into the sheet of fibrous material and selectively adjusting a distance between the non-permeable bladder and the fibrous material at a gap, formed in the permeable media layer, such that a first resistance to fluid flow through the permeable media layer is reduced.

Abstract: A run-flat tire insert for installation in a pneumatic tire mounted on a rim. The insert is a one-piece toroidal member formed from expanded polymer foam beads molded into a structural foam part. The insert has an inner diameter surface sized to fit snuggly about a periphery of a tire rim and an outer diameter sized to fit within a tire cavity. The insert is spaced from the tire inner casing surface during normal operation and supports the tire inner casing surface away from the rim in the event of a flat tire. A molding apparatus and a method of forming a run-flat tire insert is also disclosed.

Abstract: A plastic article is recited having a plastic shell including walls defining a cavity. Within the cavity is an in-situ foam core including expanded polymer beads. A layer of the expanded polymer beads includes a layer of distorted beads adjacent to the walls. The in-situ foam core has a thermal bond to the walls.

Abstract: The plastic structural article includes an elongated tubular shell having opposed end sections, a middle section there between and an interior cavity. The interior cavity has a foam core situated therein. The foam core comprises steam expandable polymer beads which when expanded substantially fill the interior cavity. The bead and shell are of a similar plastic composition enabling the articles to be reground and recycled. An apparatus for forming the articles and an associated method of manufacture are also disclosed. A thermal management system includes a panel having a periphery, and a skin having a thermal bond to an in-situ foam core. The panel has a thermal transmittance u-value ranging from 0.1 to 0.17 W/m2° C.

Abstract: The plastic structural article includes an elongated tubular shell having opposed end sections, a middle section there between and an interior cavity. The interior cavity has a foam core situated therein. The foam core comprises steam expandable polymer beads which when expanded substantially fill the interior cavity. The bead and shell are of a similar plastic composition enabling the articles to be reground and recycled. An apparatus for forming the articles and an associated method of manufacture are also disclosed.

Abstract: An in-situ foam core component having first and second opposed thermoformed skins each having a thermal bond to an in-situ foam core disposed there between. At least one embossment In one of the skins joined to the other skin forming a pinch off junction. A through hole is formed in the pinch off junction sized to receive a fastener so that the embossment provides a sleeve structure which can transmit load between the first and second skins when the in-situ foam core component is attached to a member using a fastener extending through the hole.

Abstract: Described herein is a system for infusing liquid resin into a sheet of fibrous material. The system comprises a tool and a permeable media layer, configured to have the sheet therebetween. The system further comprises a non-permeable bladder configured to be sealed to the tool about the sheet of fibrous material and the permeable media layer such that the sheet of fibrous material and the permeable media layer are sealed between the non-permeable bladder and the tool. The system additionally comprises an inlet selectively fluidly coupleable with the permeable media layer to deliver liquid resin to the permeable media layer. The system also comprises an outlet selectively fluidly coupleable with the permeable media layer to create a pressure differential across the non-permeable bladder. The system further comprises a permeability control valve selectively operable to adjust the permeability of the permeable media layer.

Abstract: An in-situ molded foam core structural plastic article having an outer shell with an interior cavity filled with expandable polymer beads which when expanded substantially fill the interior cavity forming a thermal bond with the shell. The bead and shell are of a similar plastic composition enabling the articles to be reground and recycled. Various articles are disclosed including structural panels, and automotive seat, load floor, interior panel, bumper and running board components. An apparatus for forming the articles and an associated method of manufacture are also disclosed.

Abstract: Provided are compositions and methods for labeling an endogenous protein, in particular, in a live cell, or for ablating an endogenous or target protein. The compositions relate to a fusion protein having a binding moiety such as an antibody, an antigen binding fragment of an antibody or an antibody mimetic that recognizes the endogenous or target protein.

Abstract: A floor support structure for a bathtub or a shower tray floor, taking the form of a separate element to be used in conjunction with a traditional bathtub or shower tray floor, or as a unitary shower tray floor formed with the support structure integrated therein. The supports include a hollow plastic shell having a lower surface for lying on a planar subfloor, an upper surface contoured to the desired shape and a peripheral sidewall extending there between. Preferably, a drain hole is formed in the plastic shell which also interconnects the upper and lower surfaces thereby defining a hollow interior cavity. The cavity is filled with expandable thermoplastic foam beads which are expanded in place with steam in order to substantially fill the interior cavity thermally bonding the beads together and to the shell interior wall. The expanded foam bead is capable of being compressed without substantial permanent set.

Abstract: Provided herein are methods to generate and screen peptides that exhibit drug like stabilities in vitro and in vivo. By selecting for enzyme resistance, Applicants are able to derive peptides that are not only stable to a broad spectrum of proteases, but also stable to other drug processing enzymes such as cytochrome P450s. This approach provides a general method to the rapid development of highly stable peptides for therapeutic development and diagnosis. The peptides are further modified for oral bioavailability.

Abstract: Provided herein are methods to generate and screen peptides that exhibit drug like stabilities in vitro and in vivo. By selecting for enzyme resistance, Applicants are able to derive peptides that are not only stable to a broad spectrum of proteases, but also stable to other drug processing enzymes such as cytochrome P450s. This approach provides a general method to the rapid development of highly stable peptides for therapeutic development and diagnosis. The peptides are further modified for oral bioavailability. The methods can be applied to similar peptides for the making of therapeutic compositions.

Abstract: Provided are compositions and methods for labeling an endogenous protein, in particular, in a live cell, or for ablating an endogenous or target protein. The compositions relate to a fusion protein having a binding moiety such as an antibody, an antigen binding fragment of an antibody or an antibody mimetic that recognizes the endogenous or target protein.

Abstract: An elongated structural article, having a continuous profile extrusion with spaced apart layers defining a portion of a cavity filed filled with thermoplastic pre-expanded beads expanded with steam in-situ causing the beads to securely bond together and to the profile extrusion. The article is cut to a length forming ends having an exposed foam core. A system for manufacturing the article is also disclosed having a profile extrusion die for forming an axially profile defining a wall surrounding a cavity, a tubular shaping mold located axially downstream of the extrusion die sized to support a length of the profile as it passes there through. A bead dispenser is oriented to introducing pre-expanded beads into the profile cavity while within the shaping fixture and a steam tube is oriented downstream of the introduction of pre-expanded beads. Control valves regulate the flow of pre-expanded beads and steam into the profile cavity.

Abstract: A plastic article is recited having a plastic shell including walls defining a cavity. Within the cavity is an in-situ foam core including expanded polymer beads. A layer of the expanded polymer beads includes a layer of distorted beads adjacent to the walls. The in-situ foam core has a thermal bond to the walls.

Abstract: The plastic structural article includes an elongated tubular shell having opposed end sections, a middle section there between and an interior cavity. The interior cavity has a foam core situated therein. The foam core comprises steam expandable polymer beads which when expanded substantially fill the interior cavity. The bead and shell are of a similar plastic composition enabling the articles to be reground and recycled. An apparatus for forming the articles and an associated method of manufacture are also disclosed.