Abstract: The present invention relates to TLR7 agonists according to Formula I and their use in the treatment of diseases such as cancer and infectious disease.

Abstract: A hose positioner having an body with a passageway extending therethrough. The body is adapted to receive a hose into the passageway. The hose positioner also includes a connecting member extending from the elongate body which is adapted to be releasably retained with a connector.

Abstract: A hose positioner having an body with a passageway extending therethrough. The body is adapted to receive a hose into the passageway. The hose positioner also includes a connecting member extending from the elongate body which is adapted to be releasably retained with a connector.

Abstract: An applicator for animal identification tags comprises a tag magazine receiver configured to receive a tag magazine comprising a reservoir for holding a plurality of discrete animal identification tags, each comprising a male and female engagement portion, and an opening, wherein the identification tags are displaceable along the reservoir to be sequentially dispensed through the opening. A pair of jaws engage male and female portions of a dispensed identification tag through the ear of an animal placed between the jaws. A motorized tag dispenser displaces the identification tags along the reservoir of a received tag magazine to sequentially dispense the identification tags through the opening. A sensor senses information indicative that an identification tag has been dispensed through the opening and received by the pair of jaws. A controller stops operation of the motorized tag dispenser based on an output of the sensor.

Abstract: A coating of an encapsulated electrophoretic medium is formed on a substrate (106) by dispersing in a fluid (104) a plurality of electrophoretic capsules (102), contacting at least a portion of a substrate (106) with the fluid (104); and applying a potential difference between at least a part of the portion of the substrate (106) contacting the fluid (104) and a counter-electrode (110) in electrical contact with the fluid (104), thereby causing capsules (102) to be deposited upon at least part of the portion of the substrate (106) contacting the fluid (102). Patterned coatings of capsules containing different colors may be deposited in registration with electrodes using multiple capsule deposition steps. Alternatively, patterned coatings of capsules may be formed by applying a fluid form of an electrophoretic medium to a substrate, and applying a temporally varying voltage between an electrode and the substrate. The process may be repeated to allow for deposition of full color displays.

Abstract: A system for constructing image slices through a selected object, the system comprising an identifiable fiducial reference in a fixed position relative to the selected object, wherein the fiducial reference comprises at least two identifiable reference markers. A source of radiation is provided for irradiating the selected object and the fiducial reference to form a projected image of the selected object and the fiducial reference which is recorded by a recording medium.

Abstract: A laminate comprising a solid electro-optic medium and an electrically conductive layer is tested by passing it over a pair of electrodes at different potentials, with the electrically conductive layer lying on the opposed side of the electro-optic medium from the electrodes. An article which can be tested by this method, and which is useful in the manufacture of electro-optic displays, comprises a layer of a solid electro-optic medium and a release sheet comprising an electrically conductive layer.

Abstract: The image stability of electrophoretic media, comprising a plurality of particles disposed in a fluid and capable of moving through the fluid upon application of an electric field to the medium, can be improved by including in the fluid either a polystyrene or an aggregating diblock copolymer which forms micelle-like structures in the fluid, the diblock copolymer having a first block soluble in the fluid and a second block not swellable by the fluid. In variable transmission electrophoretic media, haze can be reduced by using as the fluid a mixture of a partially hydrogenated aromatic hydrocarbon and a terpene.

Abstract: An electro-optic display comprises a layer (130) of a solid electro-optic material, at least one electrode disposed adjacent the layer (130) of electro-optic material, and a layer (180) of a lamination adhesive interposed between the layer (130) of electro-optic material and the electrode, the lamination adhesive (180) having a higher electrical conductivity in a direction perpendicular to the layer of lamination adhesive than in the plane of the layer.

Abstract: The invention provides materials and methods (including driving methods) for reducing the effects of remnant voltages in electro-optic displays.

Abstract: A system for constructing image slices through a selected object, the system comprising an identifiable fiducial reference in a fixed position relative to the selected object, wherein the fiducial reference comprises at least two identifiable reference markers. A source of radiation is provided for irradiating the selected object and the fiducial reference to form a projected image of the selected object and the fiducial reference which is recorded by a recording medium.

Abstract: A system and method for producing three-dimensional representations of an object. A first series of projected images of the selected object is recorded in a first projection plane and a second series of projected images of the selected object is recorded in a second projection plane. The first and the second series of projected images are rendered at a common magnification. The first set of projected images is then integrated into a first three-dimensional volume and the second set of projected images is integrated into a second three-dimensional volume. The three-dimensional representation of the object is then produced by combining one projected image from the first set of projected images with one projected image from the second set of projected images. Alternatively, the three-dimensional representation is produced by merging the first three-dimensional volume with the second three-dimensional volume.