Abstract: A chromatographic purification method for the isolation of a product from a feed mixture using two columns, wherein in one step b) the first upstream column is loaded with feed, followed by at least one interconnected step c), wherein in the interconnected step c) the first column is fed with eluent with a gradient, wherein the stream exiting the first column is adjusted inline with inline adjustment eluent before entering the second column during the period of gradient elution, and wherein the inline adjustment eluent is as the eluent fed at the first column inlet but controlled to have a higher or lower modifier concentration than the eluent exiting at the first column, and wherein the modifier difference of the inline adjustment eluent is chosen such that the adherence of the product to the stationary phase of the second column is higher than without that difference.

Abstract: A cyclic chromatographic purification method for the isolation of a product from a feed mixture comprising the product and at least two further components representing weakly adsorbing impurities and strongly adsorbing impurities, the method using only two chromatographic adsorber sections as chromatographic stationary phase. The method comprises at least one base sequence having at least one Recycling Phase followed by only one Purification Phase, wherein preferably base sequences repeat in a cyclic manner.

Abstract: Provided herein are compositions, methods and uses involving antibodies that specifically bind to MET, a receptor tyrosine kinase, and modulate the expression and/or activity of MET. Also provided are uses and methods for managing, treating, or preventing disorders, such as cancer. In one aspect, provided herein is a monoclonal antibody or antigen-binding fragment thereof that binds to the Sema/PSI domain of human MET. Also provided herein is a kit comprising an antibody or antigen-binding fragment provided herein. Also provided herein is a method of managing, protecting against, or treating cancer in a subject, comprising administering to a subject in need thereof a therapeutically effective amount of an antibody or antigen-binding fragment provided herein.

Abstract: Provided herein are compositions, methods and uses involving antibodies that specifically bind to MET, a receptor tyrosine kinase, and modulate the expression and/or activity of MET. Also provided are uses and methods for managing, treating, or preventing disorders, such as cancer. In one aspect, provided herein is a monoclonal antibody or antigen-binding fragment thereof that binds to the Sema/PSI domain of human MET. Also provided herein is a kit comprising an antibody or antigen-binding fragment provided herein. Also provided herein is a method of managing, protecting against, or treating cancer in a subject, comprising administering to a subject in need thereof a therapeutically effective amount of an antibody or antigen-binding fragment provided herein.

Abstract: Provided herein are compositions, methods and uses involving antibodies that specifically bind to MET, a receptor tyrosine kinase, and modulate the expression and/or activity of MET. Also provided are uses and methods for managing, treating, or preventing disorders, such as cancer. In one aspect, provided herein is a monoclonal antibody or antigen-binding fragment thereof that binds to the Sema/PSI domain of human MET. Also provided herein is a kit comprising an antibody or antigen-binding fragment provided herein. Also provided herein is a method of managing, protecting against, or treating cancer in a subject, comprising administering to a subject in need thereof a therapeutically effective amount of an antibody or antigen-binding fragment provided herein.

Abstract: A occurrence marketing server communicates with a database to store and retrieve information related to solution seekers, solution providers, surveys, survey responses and social networking data. A universal solution code (USC) is assigned to a set of solution assets configurable into a webpage describing the solution. The occurrence marketing server communicates with mobile devices via an SMS gateway to send and receive text messages. A dashboard is made available to solution seekers and providers. A mobile lead retrieval application uses a badge code to correlate and provide surveys to solution seekers. An information request application accepts and responds to USC codes via SMS text messaging.

Abstract: A central server system communicates with a plurality of communication devices known as RTLS tags worn by participants of an event in a facility. The RTLS tags communicate with a network located in the vicinity of the facility to determine the position of the RTLS tags in real time. The network transfers information to and from a RTIMS server. Information about identities of the participants, the location of the participants and geographical maps of display booths and exhibitor signage at the event are stored on the RTIMS server in a data store. Reciprocity between participants and exhibitors may be established. The data store may be queried to provide participants information relevant for navigation, lead capture, participant surveys and participant traffic flow. Participant locations may be correlated to entity locations or other participants by the RTIMS system to provide location oriented services. There is a data generation plan for the event design.

Abstract: A central server system is provided which communicates with a plurality of communication devices known as RTLS tags which are usually worn by participants of an event, the event being normally contained to a facility. The RTLS tags communicate with a network located in the vicinity of the facility to determine the position of the RTLS tags in real time. The network communicates with and transfers information to and from a RTIMS server. Information about identities of the participants, the location of the participants and geographical maps of display booths and exhibitor signage at the event are stored on the RTIMS server in a datastore connected thereto. The datastore may be queried to provide participants information relevant for navigation, lead capture, participant surveys and participant traffic flow. Participant locations may be correlated to entity locations or other participants by the RTIMS system to provide location oriented services.