Abstract: The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IRES activity.

Abstract: Novel acetylamino benzoic acid compounds, methods of using and pharmaceutical compositions comprising an acetylamino benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay, or ameliorating one or more symptoms associated therewith.

Abstract: In accordance with the present invention, compounds that inhibit viral replication, preferably Hepatitis C Virus (HCV) replication, have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the treatment or prevention of a viral infection are provided. In another aspect of the invention, compounds useful in the treatment or prevention of HCV infection are provided.

Abstract: The present invention provides compounds, pharmaceutical compositions, and methods of using such compounds or compositions for treating infection by a virus, or for affecting viral IRES activity.

Abstract: The invention encompasses ureido substituted benzoic acid compounds, compositions comprising the compounds and methods for treating or preventing diseases associated with nonsense mutations of mRNA by administering these compounds or compositions.

Abstract: The invention encompasses nucleoside compounds, compositions comprising the compounds and methods for treating or preventing diseases associated with nonsense mutations of mRNA by administering these compounds or compositions.

Abstract: Novel acetylamino benzoic acid compounds, methods of using and pharmaceutical compositions comprising an acetylamino benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of premature translation termination or nonsense-mediated mRNA decay, or ameliorating one or more symptoms associated therewith.

Abstract: A method of quickly and robustly localizing a pair of concentric circular region boundaries in a digital image, such as the pupil and iris boundaries in an image of a human eye is disclosed. Specularities in the image are optionally filled. An object containing concentric regions, e.g., a pupil and iris, is found within the image.

Abstract: Overlapping connections of sheet metal members in structural components are ested for cracks or flaws which are primarily the result of wear and tear under operating load conditions. For this purpose a test hole is made into or through the overlapping sheet metal members whereby each sheet metal member is provided with its own test hole portion. As long as the connection is still in good condition, adjacent test hole portions remain in register with each other. A sensor is inserted into the test hole. The sensor provides an indication of a faulty connection when the test hole portions are no longer in register. Several different types of sensors may be employed. The monitoring of the test holes and/or sensors may be made in a manual or automatic manner.