Abstract: The invention relates to a novel group of compounds of Formula (I) or salts thereof: wherein Y, Z1, Z2, R1, R4, R5 and n are as described in the specification, which may be useful in the treatment or prevention of a disease or medical condition mediated through protein kinase B (PKB) such as cancer. The invention also relates to pharmaceutical compositions comprising said compounds, methods of treatment of diseases mediated by PKB using said compounds and methods for preparing compounds of Formula (I).

Abstract: The subject matter of this specification can be implemented in, among other things, a computer-implemented method that includes identifying metadata related to television programming being presented on a display device. The method further includes extracting one or more keywords from the metadata. The method further includes generating multiple search suggestions based on the keywords and first search results based on one or more of the search suggestions. The method further includes presenting the search suggestions and the first search results together on the display device.

Abstract: A system and method for automating railroad maintenance by a tie gang using electronic tie marking (ETM) configured to optimize railroad asset maintenance. The system enables collision avoidance between members of the tie gang performing maintenance on railway assets (e.g., Rails, Ties, Ballasts, Turnouts, Crossings, etc.). The system can generate production numbers for the railway assets and evaluate an asset queue for the tie gang to perform maintenance. The system can utilize real-time updates from the tie gang to optimize work output. The system can provide a customizable user interface to identify, track, and process information related to maintenance of the railroad asset. The system also provides for a heads-up-display (HUD) to notify an operator of relevant information, such as maintenance information, travel indicators, and updated asset queue. The system can identify a next location and calculate an optimum path based on sensor input incorporating machine-specific and environmental characteristics.

Abstract: A system and method for automating railroad maintenance by a tie gang using electronic tie marking (ETM) configured to optimize railroad asset maintenance. The system enables collision avoidance between members of the tie gang performing maintenance on railway assets (e.g., Rails, Ties, Ballasts, Turnouts, Crossings, etc.). The system can generate production numbers for the railway assets and evaluate an asset queue for the tie gang to perform maintenance. The system can utilize real-time updates from the tie gang to optimize work output. The system can provide a customizable user interface to identify, track, and process information related to maintenance of the railroad asset. The system also provides for a heads-up-display (HUD) to notify an operator of relevant information, such as maintenance information, travel indicators, and updated asset queue. The system can identify a next location and calculate an optimum path based on sensor input incorporating machine-specific and environmental characteristics.

Abstract: A system and method for automating railroad maintenance for a tie gang using electronic tie marking (ETM) configured to optimize railroad asset maintenance. The system enables the automating of an adaptive maintenance process for the asset that is being maintainanced. The system can identify a railroad asset scheduled for maintenance using various forms of inspection including real-time kinematic (RTK)-corrected GPS data, radar signal processing data, and real-time imaging. The system also provides for the acquisition and upload of asset pictures for verification and analysis of a railroad asset. The system can identify a next location to perform maintenance and can calculate an optimum path based on sensor input incorporating machine-specific and environmental characteristics. The system further can provide a customizable user interface to identify, track, and process information related to maintenance of the railroad asset.

Abstract: A system and method for automating railroad maintenance for a tie gang using electronic tie marking (ETM) configured to optimize railroad asset maintenance. The system enables the automating of an adaptive maintenance process for the asset that is being maintainanced. The system can identify a railroad asset scheduled for maintenance using various forms of inspection including real-time kinematic (RTK)-corrected GPS data, radar signal processing data, and real-time imaging. The system also provides for the acquisition and upload of asset pictures for verification and analysis of a railroad asset. The system can identify a next location to perform maintenance and can calculate an optimum path based on sensor input incorporating machine-specific and environmental characteristics. The system further can provide a customizable user interface to identify, track, and process information related to maintenance of the railroad asset.

Abstract: A method, computer system, and computer program product for migrating a service (e.g. microservice) from using a first application programming interface version to using a second (e.g. newer or updated) application programming interface version. The method may include determining a difference between specifications of the first and second versions of the application programming interface. Historical usage of the first version of the application programming interface by the service may then be analyzed with respect to the difference so as to determine if the service meets the specification of the second version of the application programming interface. Responsive to determining the service meets the specification of the second version of the application programming interface difference, the service may be migrated from using the first version of the application programming interface to using the second version of the application programming interface.

Abstract: Systems and techniques are described for alerting individuals of HVAC system issues in their home. In some implementations, a monitoring system monitors a property that includes sensors located throughout the property and generates sensor data. A monitor control unit receives thermostat data from a thermostat that indicates activity of the HVAC system and temperature history of the property. The monitor control unit applies the thermostat and the sensor data to an HVAC model that is trained using past sensor data, past thermostat data, past errors of the HVAC system. The monitor control unit determines an error of the HVAC system from the HVAC model output. The monitor control unit determines an action for likely correcting the error of the HVAC system. The monitor control unit provides, for output, data identifying the error of the HVAC system and the action for likely correcting the error of the HVAC system.

Abstract: An amplifier operable with an electric drive signal can amplify signal light having a signal wavelength. A laser diode has an active section with input and output facets. The facets are in optical communication with the signal light and are configured to pass the signal light through the laser diode. The active section is configured to generate pump light in response to injection of the electrical drive signal into the active section. The pump light has a pump wavelength different from the signal wavelength. A doped fiber doped with an active dopant is in optical communication with the signal light and is in optical communication with at least a portion of the pump light from the laser diode. The pump wavelength of the pump light is configured to interact with the active dopant of the fiber and thereby amplify the signal light.

Abstract: A method for obtaining information encoded on an electrochemical test strip is provided. The test strip has two electrodes disposed within a sample space and the information is encoded on the test strip prior to introduction of liquid sample. The method includes the step of introducing sample to the sample space so that the sample is in contact with the two electrodes within the sample space. In another step a value is determined that is representative of the double layer capacitance of the test strip and/or the equivalent capacitance of the test strip. The determined value is then translated into information reflecting a characteristic of the test strip prior to introduction of sample.

Abstract: Systems and methods for using transmission sensor(s) in localization of an autonomous vehicle (“AV”) are described herein. Some implementations receive instance(s) of transmission sensor data generated by transmission sensor(s) of the AV, generate pose instance(s) of a pose of the AV based on the instance(s) of the transmission sensor data, and cause the AV to be controlled based on the pose instance(s). In some of those implementations, the pose instance(s) can be generated based on steering data the AV that indicates steering angle(s) of the autonomous, and that temporally correspond to the instance(s) of the transmission sensor data. In various implementations, the pose instance(s) may only be generated or utilized based on the instance(s) of the transmission sensor data (and optionally the steering data) in response to detecting an adverse event at the AV.

Abstract: The present disclosure provides antibodies and antigen-binding fragments capable of binding PAR2. In some embodiments, the anti-PAR2 antibodies or antigen-binding fragments thereof bind PAR2 in a pH-dependent manner. The disclosure further provides methods for making and using the antibodies and antigen-binding fragments.

Abstract: Disclosed are methods for forming shear-thinning fluid gel compositions comprising a microgel particle-forming polymer dispersed in an aqueous medium. The viscosity of the fluid gel compositions reduces when the gel is exposed to shear. Also disclosed are shear-thinning fluid gel compositions obtained by such methods, and medical uses of such compositions.

Abstract: A system includes: a screen configured for wear by a user, the screen configured to display a 2-dimensional (2D) element; a processing unit coupled to the display; and a user input device configured to generate a signal in response to a user input for selecting the 2D element displayed by the screen; wherein the processing unit is configured to obtain a 3-dimensional (3D) model associated with the 2D element in response to the generated signal.

Abstract: A temperature sensor assembly for measuring a gas temperature in a gas flow stream includes a first substrate having a first surface configured to be connected to a thermally conductive structure in a gas path, a first temperature sensor mounted to the first substrate a first distance from the first surface, and a second temperature sensor mounted to the first substrate a second distance from the first surface. The second distance is less than the first distance. The first and second temperature sensors are arranged along a temperature gradient.

Abstract: Disclosed are methods for forming shear-thinning fluid gel compositions comprising a microgel particle-forming polymer dispersed in an aqueous medium. The viscosity of the fluid gel compositions reduces when the gel is exposed to shear. Also disclosed are shear-thinning fluid gel compositions obtained by such methods, and medical uses of such compositions.

Abstract: Methods and devices for assembling a fiber optic connector are provided. A device supports at least one fiber optic connector. The connector has an optical fiber inserted through the ferrule so that an exposed portion is disposed outside of the ferrule. Residual epoxy on the exposed portion is cured prior to physically manipulating the optical fiber within the ferrule. The device includes at least one heating chamber and a heat shield for curing of the residual epoxy.

Abstract: Embodiments of the systems described herein can implement one or more visitor tearing processes. Visitor tearing can include, among other things, one or more processes by which multiple visitors that may appear to be the same visitor may be separated into different visitor profiles due to the leveraging of one or more unique persistent identifiers.

Abstract: A module for a base station monopole has a wall defining an interior space. The wall includes an opening configured to receive electronic equipment and a vent opening in communication with the exterior of the module. A reinforcement member is secured to the wall and is positioned opposite to the opening and adjacent the vent opening. A baffle is supported adjacent the wall where the baffle has an intake opening and an exhaust opening in communication with the vent opening. The intake opening is laterally offset from the exhaust opening.

Abstract: A system for data recording across a network includes a session border controller connecting incoming data from the network to an endpoint recorder. A load balancer is connected to the network between the session border controller and the endpoint and receives the incoming data from the session border controller, wherein the load balancer comprises computer memory and a processor configured to parse the incoming data into video data and audio data according to identification protocols accessible by the processor from the computer memory. A recording apparatus includes recording memory that receives the incoming data from the load balancer, stores a duplicate version of the incoming data in the recording memory, and connects the incoming data to the endpoint.