Patents by Inventor Richard Woolf

Richard Woolf has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Expansion of non-haematopoietic tissue-resident gamma delta T cells and uses of these cells
    Patent number: 12637659
    Abstract: This invention relates to the expansion of non-haematopoietic tissue-resident ?? T cells in vitro by culturing lymphocytes obtained from non-haematopoietic tissue of humans or non-human animals in the presence of interleukin-2 (IL-2) and/or interleukin-15 (IL-15) and the absence of TCR activation or co-stimulation signals, without any direct contact with stromal or epithelial cells. Methods of non-haematopoietic tissue-resident ?? T cell expansion are provided, as well as populations of non-haematopoietic tissue-resident ?? T cells and uses thereof.
    Type: Grant
    Filed: September 29, 2022
    Date of Patent: May 26, 2026
    Assignees: CANCER RESEARCH TECHNOLOGY LIMITED, KING'S COLLEGE LONDON, THE FRANCIS CRICK INSTITUTE LIMITED
    Inventors: Adrian Hayday, Oliver Nussbaumer, Richard Woolf
  • Expansion of ?? T cells, compositions, and methods of use thereof
    Patent number: 12458698
    Abstract: The present invention provides methods of expanding ?? T cells from a non-haematopoietic tissue source. Further provided are compositions of expanded ?? T cells and methods of using the expanded ?? T cells (e.g., a part of an adoptive T cell therapy).
    Type: Grant
    Filed: January 12, 2023
    Date of Patent: November 4, 2025
    Assignees: King's College London, GammaDelta Therapeutics Limited
    Inventors: Richard Beatson, Adrian Hayday, Oliver Nussbaumer, Richard Woolf, Maria Luisa Iannitto, Natalie Mount
  • EXPANSION OF GAMMA DELTA T CELLS, COMPOSITIONS, AND METHODS OF USE THEREOF
    Publication number: 20230242878
    Abstract: The present invention provides methods of expanding ?? T cells from a non-haematopoietic tissue source. Further provided are compositions of expanded ?? T cells and methods of using the expanded ?? T cells (e.g., a part of an adoptive T cell therapy).
    Type: Application
    Filed: January 12, 2023
    Publication date: August 3, 2023
    Inventors: Richard BEATSON, Adrian HAYDAY, Oliver NUSSBAUMER, Richard WOOLF, Maria Luisa IANNITTO, Natalie MOUNT
  • Expansion of ?? T cells, compositions, and methods of use thereof
    Patent number: 11655453
    Abstract: The present invention provides methods of expanding ?? T cells from a non-haematopoietic tissue source. Further provided are compositions of expanded ?? T cells and methods of using the expanded ?? T cells (e.g., apart of an adoptive T cell therapy).
    Type: Grant
    Filed: May 3, 2018
    Date of Patent: May 23, 2023
    Assignees: King's College London, GammaDelta Therapeutics LTD
    Inventors: Richard Beatson, Adrian Hayday, Oliver Nussbaumer, Richard Woolf, Maria Luisa Iannitto, Natalie Mount
  • Expansion of non-haematopoietic tissue-resident gamma delta T cells and uses of these cells
    Patent number: 11618885
    Abstract: This invention relates to the expansion of non-haematopoietic tissue-resident ?? T cells in vitro by culturing lymphocytes obtained from non-haematopoietic tissue of humans or non-human animals in the presence of interleukin-2 (IL-2) and/or interleukin-15 (IL-15) and the absence of TCR activation or co-stimulation signals, without any direct contact with stromal or epithelial cells. Methods of non-haematopoietic tissue-resident ?? T cell expansion are provided, as well as populations of non-haematopoietic tissue-resident ?? T cells and uses thereof.
    Type: Grant
    Filed: October 31, 2016
    Date of Patent: April 4, 2023
    Inventors: Adrian Hayday, Oliver Nussbaumer, Richard Woolf
  • EXPANSION OF NON-HAEMATOPOIETIC TISSUE-RESIDENT GAMMA DELTA T CELLS AND USES OF THESE CELLS
    Publication number: 20230099491
    Abstract: This invention relates to the expansion of non-haematopoietic tissue-resident ?? T cells in vitro by culturing lympho-cytes obtained from non-haematopoietic tissue of humans or non-human animals in the presence of interleukin-2 (IL-2) and/or inter-leukin-15 (IL-15) and the absence of TCR activation or co-stimulation signals, without any direct contact with stromal or epithelial cells. Methods of non-haematopoietic tissue-resident ?? T cell expansion are provided, as well as populations of non-haematopoietic tissue-resident ?? T cells and uses thereof.
    Type: Application
    Filed: September 29, 2022
    Publication date: March 30, 2023
    Inventors: Adrian HAYDAY, Oliver NUSSBAUMER, Richard WOOLF
  • EXPANSION OF GAMMA DELTA T CELLS, COMPOSITIONS, AND METHODS OF USE THEREOF
    Publication number: 20210087528
    Abstract: The present invention provides methods of expanding ?? T cells from a non-haematopoietic tissue source. Further provided are compositions of expanded ?? T cells and methods of using the expanded ?? T cells (e.g., apart of an adoptive T cell therapy).
    Type: Application
    Filed: May 3, 2018
    Publication date: March 25, 2021
    Applicants: King's College London, GammaDelta Therapeutics Limited, GammaDelta Therapeutics Limited
    Inventors: Richard BEATSON, Adrian HAYDAY, Oliver NUSSBAUMER, Richard WOOLF, Maria Luisa IANNITTO, Natalie MOUNT
  • EXPANSION OF NON-HAEMATOPOIETIC TISSUE-RESIDENT GAMMA DELTA T CELLS AND USES OF THESE CELLS
    Publication number: 20180312808
    Abstract: This invention relates to the expansion of non-haematopoietic tissue-resident ?? T cells in vitro by culturing lymphocytes obtained from non-haematopoietic tissue of humans or non-human animals in the presence of interleukin-2 (IL-2) and/or interleukin-15 (IL-15) and the absence of TCR activation or co-stimulation signals, without any direct contact with stromal or epithelial cells. Methods of non-haematopoietic tissue-resident ?? T cell expansion are provided, as well as populations of non-haematopoietic tissue-resident ?? T cells and uses thereof.
    Type: Application
    Filed: October 31, 2016
    Publication date: November 1, 2018
    Inventors: Adrian HAYDAY, Oliver NUSSBAUMER, Richard WOOLF
  • Apparatus and method for forming powder metal gears
    Patent number: 6517772
    Abstract: A compacted and sintered gear blank is supported for rotation about a first axis adjacent a tool supported for rotation about a second axis transverse to the first axis. The tool has a series of gear cutting teeth and an adjacent set of gear densifying portions. The gear cutting teeth of the tool are moved into engagement with the powder metal gear blank to cut gear teeth into the blank. The tool is then shifted to bring the densifying portions of the tool into engagement with the teeth and the surfaces of the teeth densified by the tool.
    Type: Grant
    Filed: September 26, 2001
    Date of Patent: February 11, 2003
    Assignee: Federal-Mogul World Wide, Inc.
    Inventor: Richard Woolf